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Implementation and effectiveness of antiretroviral therapy in Greenland.

Lohse N, Ladefoged K, Obel N - Emerging Infect. Dis. (2008)

Bottom Line: Analyses from the Danish HIV Cohort Study showed that, despite comparable economic means and general education of healthcare personnel, antiretroviral treatment of HIV in Greenland began later and has been implemented at a slower pace with lower therapeutic effectiveness than in Denmark.However, implementation and quality of care improved considerably in recent years.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Epidemiology, Arhus University Hospital, Arhus, Denmark. nl@dce.au.dk

ABSTRACT
Analyses from the Danish HIV Cohort Study showed that, despite comparable economic means and general education of healthcare personnel, antiretroviral treatment of HIV in Greenland began later and has been implemented at a slower pace with lower therapeutic effectiveness than in Denmark. However, implementation and quality of care improved considerably in recent years.

Show MeSH
A). Proportion of patients with low CD4 cell count on January 1, 1996–2006. Numerator, patients with a CD4 cell count <300 cells/μL. Denominator, all patients who had not yet been prescribed a highly active antiretroviral therapy (HAART) regimen. B) Proportion of patients with suppressed viral load on January 1, 1996–2006. Numerator, patients with an HIV RNA <400 copies per mL. Denominator, all patients who had ever started a HAART regimen.
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Figure 2: A). Proportion of patients with low CD4 cell count on January 1, 1996–2006. Numerator, patients with a CD4 cell count <300 cells/μL. Denominator, all patients who had not yet been prescribed a highly active antiretroviral therapy (HAART) regimen. B) Proportion of patients with suppressed viral load on January 1, 1996–2006. Numerator, patients with an HIV RNA <400 copies per mL. Denominator, all patients who had ever started a HAART regimen.

Mentions: Until 2002, >30% of patients not yet receiving HAART in Greenland had a CD4 cell count <300 cells/μL (Figure 2). In comparison, the proportion in Denmark has been <30% since 1998, with <5% having a CD4 cell count <200 cells/μL since 2001. Among patients ever starting a HAART regimen, the proportion with suppressed viral load in Greenland was <45% until 2003 but has increased to 73% in 2006 (Figure 2). Nuuk reached the 75% mark in 2004, whereas the increase in the remote districts started later and reached 69% in 2006. The proportions in Denmark were 62% in 1998, 81% in 2003, and 88% in 2006.


Implementation and effectiveness of antiretroviral therapy in Greenland.

Lohse N, Ladefoged K, Obel N - Emerging Infect. Dis. (2008)

A). Proportion of patients with low CD4 cell count on January 1, 1996–2006. Numerator, patients with a CD4 cell count <300 cells/μL. Denominator, all patients who had not yet been prescribed a highly active antiretroviral therapy (HAART) regimen. B) Proportion of patients with suppressed viral load on January 1, 1996–2006. Numerator, patients with an HIV RNA <400 copies per mL. Denominator, all patients who had ever started a HAART regimen.
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Related In: Results  -  Collection

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Figure 2: A). Proportion of patients with low CD4 cell count on January 1, 1996–2006. Numerator, patients with a CD4 cell count <300 cells/μL. Denominator, all patients who had not yet been prescribed a highly active antiretroviral therapy (HAART) regimen. B) Proportion of patients with suppressed viral load on January 1, 1996–2006. Numerator, patients with an HIV RNA <400 copies per mL. Denominator, all patients who had ever started a HAART regimen.
Mentions: Until 2002, >30% of patients not yet receiving HAART in Greenland had a CD4 cell count <300 cells/μL (Figure 2). In comparison, the proportion in Denmark has been <30% since 1998, with <5% having a CD4 cell count <200 cells/μL since 2001. Among patients ever starting a HAART regimen, the proportion with suppressed viral load in Greenland was <45% until 2003 but has increased to 73% in 2006 (Figure 2). Nuuk reached the 75% mark in 2004, whereas the increase in the remote districts started later and reached 69% in 2006. The proportions in Denmark were 62% in 1998, 81% in 2003, and 88% in 2006.

Bottom Line: Analyses from the Danish HIV Cohort Study showed that, despite comparable economic means and general education of healthcare personnel, antiretroviral treatment of HIV in Greenland began later and has been implemented at a slower pace with lower therapeutic effectiveness than in Denmark.However, implementation and quality of care improved considerably in recent years.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Epidemiology, Arhus University Hospital, Arhus, Denmark. nl@dce.au.dk

ABSTRACT
Analyses from the Danish HIV Cohort Study showed that, despite comparable economic means and general education of healthcare personnel, antiretroviral treatment of HIV in Greenland began later and has been implemented at a slower pace with lower therapeutic effectiveness than in Denmark. However, implementation and quality of care improved considerably in recent years.

Show MeSH