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Detection of metabolic syndrome features among childhood cancer survivors: a target to prevent disease.

Siviero-Miachon AA, Spinola-Castro AM, Guerra-Junior G - Vasc Health Risk Manag (2008)

Bottom Line: Nonetheless, in what concerns children and adolescents, there are no unified definitions, and modified adult criteria have been suggested by many authors, despite major problems.Survivors of specific pediatric cancer groups, particularly acute lymphocytic leukemia, central nervous system tumors, sarcomas, lymphomas, testicular cancer, and following bone marrow transplantation, may develop metabolic syndrome traits due to: hormonal deficiencies (growth hormone deficiency, thyroid dysfunction, and gonadal failure), drug or radiotherapy damage, endothelial impairment, physical inactivity, adipose tissue dysfunction, and/or drug-induced magnesium deficiency.In conclusion, some primary and secondary prevention remarks are proposed in order to reduce premature cardiovascular disease risk in this particular group of patients.

View Article: PubMed Central - PubMed

Affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, Federal University of Sao Paulo-UNIFESPI/EPM, Brazil.

ABSTRACT
Along with the growing epidemic of obesity, the risk of atherosclerosis, cardiovascular disease morbidity, and mortality are increasing markedly. Several risk factors for cardiovascular disease, such as visceral obesity, glucose intolerance, arterial hypertension, and dyslipidemia commonly cluster together as a condition currently known as metabolic syndrome. Thus far, insulin resistance, and endothelial dysfunction are the primary events of the metabolic syndrome. Several groups have recommended clinical criteria for the diagnosis of metabolic syndrome in adults. Nonetheless, in what concerns children and adolescents, there are no unified definitions, and modified adult criteria have been suggested by many authors, despite major problems. Some pediatric disease states are at risk for premature cardiovascular disease, with clinical coronary events occurring very early in adult life. Survivors of specific pediatric cancer groups, particularly acute lymphocytic leukemia, central nervous system tumors, sarcomas, lymphomas, testicular cancer, and following bone marrow transplantation, may develop metabolic syndrome traits due to: hormonal deficiencies (growth hormone deficiency, thyroid dysfunction, and gonadal failure), drug or radiotherapy damage, endothelial impairment, physical inactivity, adipose tissue dysfunction, and/or drug-induced magnesium deficiency. In conclusion, some primary and secondary prevention remarks are proposed in order to reduce premature cardiovascular disease risk in this particular group of patients.

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Related in: MedlinePlus

Risk stratification and treatment algorithm of childhood cancer survivors (Adapted from Kavey et al 2006).Abbreviations: CVD, cardiovascular disease; M, male; F, female; BMI, body mass index; BP, blood pressure; FG, fasting glucose; HbA1C, glycated hemoglobin.
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f1-vhrm-4-0825: Risk stratification and treatment algorithm of childhood cancer survivors (Adapted from Kavey et al 2006).Abbreviations: CVD, cardiovascular disease; M, male; F, female; BMI, body mass index; BP, blood pressure; FG, fasting glucose; HbA1C, glycated hemoglobin.

Mentions: Complementary interventional recommendations for cardiovascular risk identification and reduction were developed as a consensus by a writing group convened under the joint direction of the American Heart Association’s Expert Panel on Population and Prevention Science and the Council for Cardiovascular Disease in the Young, and an algorithm was developed outlining the risk factor evaluation, management, and therapeutic recommendations (Kavey et al 2006). See Figure 1 and Table 3.


Detection of metabolic syndrome features among childhood cancer survivors: a target to prevent disease.

Siviero-Miachon AA, Spinola-Castro AM, Guerra-Junior G - Vasc Health Risk Manag (2008)

Risk stratification and treatment algorithm of childhood cancer survivors (Adapted from Kavey et al 2006).Abbreviations: CVD, cardiovascular disease; M, male; F, female; BMI, body mass index; BP, blood pressure; FG, fasting glucose; HbA1C, glycated hemoglobin.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2597761&req=5

f1-vhrm-4-0825: Risk stratification and treatment algorithm of childhood cancer survivors (Adapted from Kavey et al 2006).Abbreviations: CVD, cardiovascular disease; M, male; F, female; BMI, body mass index; BP, blood pressure; FG, fasting glucose; HbA1C, glycated hemoglobin.
Mentions: Complementary interventional recommendations for cardiovascular risk identification and reduction were developed as a consensus by a writing group convened under the joint direction of the American Heart Association’s Expert Panel on Population and Prevention Science and the Council for Cardiovascular Disease in the Young, and an algorithm was developed outlining the risk factor evaluation, management, and therapeutic recommendations (Kavey et al 2006). See Figure 1 and Table 3.

Bottom Line: Nonetheless, in what concerns children and adolescents, there are no unified definitions, and modified adult criteria have been suggested by many authors, despite major problems.Survivors of specific pediatric cancer groups, particularly acute lymphocytic leukemia, central nervous system tumors, sarcomas, lymphomas, testicular cancer, and following bone marrow transplantation, may develop metabolic syndrome traits due to: hormonal deficiencies (growth hormone deficiency, thyroid dysfunction, and gonadal failure), drug or radiotherapy damage, endothelial impairment, physical inactivity, adipose tissue dysfunction, and/or drug-induced magnesium deficiency.In conclusion, some primary and secondary prevention remarks are proposed in order to reduce premature cardiovascular disease risk in this particular group of patients.

View Article: PubMed Central - PubMed

Affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, Federal University of Sao Paulo-UNIFESPI/EPM, Brazil.

ABSTRACT
Along with the growing epidemic of obesity, the risk of atherosclerosis, cardiovascular disease morbidity, and mortality are increasing markedly. Several risk factors for cardiovascular disease, such as visceral obesity, glucose intolerance, arterial hypertension, and dyslipidemia commonly cluster together as a condition currently known as metabolic syndrome. Thus far, insulin resistance, and endothelial dysfunction are the primary events of the metabolic syndrome. Several groups have recommended clinical criteria for the diagnosis of metabolic syndrome in adults. Nonetheless, in what concerns children and adolescents, there are no unified definitions, and modified adult criteria have been suggested by many authors, despite major problems. Some pediatric disease states are at risk for premature cardiovascular disease, with clinical coronary events occurring very early in adult life. Survivors of specific pediatric cancer groups, particularly acute lymphocytic leukemia, central nervous system tumors, sarcomas, lymphomas, testicular cancer, and following bone marrow transplantation, may develop metabolic syndrome traits due to: hormonal deficiencies (growth hormone deficiency, thyroid dysfunction, and gonadal failure), drug or radiotherapy damage, endothelial impairment, physical inactivity, adipose tissue dysfunction, and/or drug-induced magnesium deficiency. In conclusion, some primary and secondary prevention remarks are proposed in order to reduce premature cardiovascular disease risk in this particular group of patients.

Show MeSH
Related in: MedlinePlus