Limits...
The clinical spectrum and treatment of Lyme disease.

Steere AC, Malawista SE, Bartenhagen NH, Spieler PN, Newman JH, Rahn DW, Hutchinson GJ, Green J, Snydman DR, Taylor E - Yale J Biol Med (1984 Jul-Aug)

Bottom Line: The illness usually begins in summer with erythema chronicum migrans and associated symptoms (stage 1).For patients with early Lyme disease, tetracycline appears to be the most effective drug, then penicillin, and finally erythromycin.High-dose intravenous penicillin is effective for the later stages of the disease.

View Article: PubMed Central - PubMed

ABSTRACT
Lyme disease was recognized as a separate entity because of close geographic clustering of affected children in Lyme, Connecticut, with what was thought to be juvenile rheumatoid arthritis. It then became apparent that Lyme disease is a complex, multisystem disorder. The illness usually begins in summer with erythema chronicum migrans and associated symptoms (stage 1). Weeks to months later, some patients develop neurologic or cardiac abnormalities (stage 2), and weeks to years later, many patients develop intermittent attacks of arthritis (stage 3), which may become chronic, with erosion of cartilage and bone. Patients with severe and prolonged illness have an increased frequency of the B-cell alloantigen, DR2. For patients with early Lyme disease, tetracycline appears to be the most effective drug, then penicillin, and finally erythromycin. High-dose intravenous penicillin is effective for the later stages of the disease.

Show MeSH

Related in: MedlinePlus

© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2590003&req=5


The clinical spectrum and treatment of Lyme disease.

Steere AC, Malawista SE, Bartenhagen NH, Spieler PN, Newman JH, Rahn DW, Hutchinson GJ, Green J, Snydman DR, Taylor E - Yale J Biol Med (1984 Jul-Aug)

© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2590003&req=5

Bottom Line: The illness usually begins in summer with erythema chronicum migrans and associated symptoms (stage 1).For patients with early Lyme disease, tetracycline appears to be the most effective drug, then penicillin, and finally erythromycin.High-dose intravenous penicillin is effective for the later stages of the disease.

View Article: PubMed Central - PubMed

ABSTRACT
Lyme disease was recognized as a separate entity because of close geographic clustering of affected children in Lyme, Connecticut, with what was thought to be juvenile rheumatoid arthritis. It then became apparent that Lyme disease is a complex, multisystem disorder. The illness usually begins in summer with erythema chronicum migrans and associated symptoms (stage 1). Weeks to months later, some patients develop neurologic or cardiac abnormalities (stage 2), and weeks to years later, many patients develop intermittent attacks of arthritis (stage 3), which may become chronic, with erosion of cartilage and bone. Patients with severe and prolonged illness have an increased frequency of the B-cell alloantigen, DR2. For patients with early Lyme disease, tetracycline appears to be the most effective drug, then penicillin, and finally erythromycin. High-dose intravenous penicillin is effective for the later stages of the disease.

Show MeSH
Related in: MedlinePlus