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Ascending sensory motor polyradiculoneuropathy with cranial nerve involvement following administration of intrathecal methotrexate and intravenous cytarabine in a patient with acute myelogenous leukemia: a case report*.

Rison RA - Cases J (2008)

Bottom Line: Acute inflammatory polyradiculoneuropathy secondary to chemotherapy for leukemia has been described in the pediatric literature.A case report is presented of an unfortunate 53 year old Hispanic woman with acute myelogenous leukemia who developed profound weakness with cranial nerve palsies following both intravenous and intrathecal chemotherapy.This is an interesting and unusual case of predominantly axonal ascending sensory motor polyradiculoneuropathy with cranial nerve involvement in an adult patient with acute myelogenous leukemia following intravenous Cytosine arabinoside and intrathecal methotrexate.

View Article: PubMed Central - HTML - PubMed

Affiliation: Whittier Presbyterian Intercommunity Hospital Stroke Center, University of Southern California, Keck School of Medicine, Los Angeles County Medical Center, Neurology Consultants Medical Group, Whittier, California, USA . rison@usc.edu.

ABSTRACT

Background: Acute inflammatory polyradiculoneuropathy secondary to chemotherapy for leukemia has been described in the pediatric literature. However, the reports are rare and have been mainly from intrathecal methotrexate in pediatric acute lymphoblastic leukemia patients who developed demyelinating polyradiculoneuropathy.

Case presentation: A case report is presented of an unfortunate 53 year old Hispanic woman with acute myelogenous leukemia who developed profound weakness with cranial nerve palsies following both intravenous and intrathecal chemotherapy.

Conclusion: This is an interesting and unusual case of predominantly axonal ascending sensory motor polyradiculoneuropathy with cranial nerve involvement in an adult patient with acute myelogenous leukemia following intravenous Cytosine arabinoside and intrathecal methotrexate.

No MeSH data available.


Related in: MedlinePlus

Muscle biopsy (ATPase stain) of the right thigh showing diffuse Type II fiber atrophy and focal myofiber degeneration.
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Figure 3: Muscle biopsy (ATPase stain) of the right thigh showing diffuse Type II fiber atrophy and focal myofiber degeneration.

Mentions: A combined muscle and nerve biopsy was performed. The sural nerve showed peripheral neuropathy with prominent evidence of axonal degeneration with digestion chambers and secondary dropout of myelinated fibers which was moderately severe (please see Figure 2). There was no evidence of vasculitis nor of endoneurial inflammation. There was no evidence of amyloid deposition nor of hypertrophic neuropathy. The muscle biopsy (right thigh) showed diffuse Type II fiber atrophy and focal myofiber degeneration (please see Figure 3).


Ascending sensory motor polyradiculoneuropathy with cranial nerve involvement following administration of intrathecal methotrexate and intravenous cytarabine in a patient with acute myelogenous leukemia: a case report*.

Rison RA - Cases J (2008)

Muscle biopsy (ATPase stain) of the right thigh showing diffuse Type II fiber atrophy and focal myofiber degeneration.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2577643&req=5

Figure 3: Muscle biopsy (ATPase stain) of the right thigh showing diffuse Type II fiber atrophy and focal myofiber degeneration.
Mentions: A combined muscle and nerve biopsy was performed. The sural nerve showed peripheral neuropathy with prominent evidence of axonal degeneration with digestion chambers and secondary dropout of myelinated fibers which was moderately severe (please see Figure 2). There was no evidence of vasculitis nor of endoneurial inflammation. There was no evidence of amyloid deposition nor of hypertrophic neuropathy. The muscle biopsy (right thigh) showed diffuse Type II fiber atrophy and focal myofiber degeneration (please see Figure 3).

Bottom Line: Acute inflammatory polyradiculoneuropathy secondary to chemotherapy for leukemia has been described in the pediatric literature.A case report is presented of an unfortunate 53 year old Hispanic woman with acute myelogenous leukemia who developed profound weakness with cranial nerve palsies following both intravenous and intrathecal chemotherapy.This is an interesting and unusual case of predominantly axonal ascending sensory motor polyradiculoneuropathy with cranial nerve involvement in an adult patient with acute myelogenous leukemia following intravenous Cytosine arabinoside and intrathecal methotrexate.

View Article: PubMed Central - HTML - PubMed

Affiliation: Whittier Presbyterian Intercommunity Hospital Stroke Center, University of Southern California, Keck School of Medicine, Los Angeles County Medical Center, Neurology Consultants Medical Group, Whittier, California, USA . rison@usc.edu.

ABSTRACT

Background: Acute inflammatory polyradiculoneuropathy secondary to chemotherapy for leukemia has been described in the pediatric literature. However, the reports are rare and have been mainly from intrathecal methotrexate in pediatric acute lymphoblastic leukemia patients who developed demyelinating polyradiculoneuropathy.

Case presentation: A case report is presented of an unfortunate 53 year old Hispanic woman with acute myelogenous leukemia who developed profound weakness with cranial nerve palsies following both intravenous and intrathecal chemotherapy.

Conclusion: This is an interesting and unusual case of predominantly axonal ascending sensory motor polyradiculoneuropathy with cranial nerve involvement in an adult patient with acute myelogenous leukemia following intravenous Cytosine arabinoside and intrathecal methotrexate.

No MeSH data available.


Related in: MedlinePlus