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Links from complex spikes to local plasticity and motor learning in the cerebellum of awake-behaving monkeys.

Medina JF, Lisberger SG - Nat. Neurosci. (2008)

Bottom Line: The hypothesis of cerebellar learning proposes that complex spikes in Purkinje cells engage mechanisms of plasticity in the cerebellar cortex; in turn, changes in the cerebellum depress the simple-spike response of Purkinje cells to a given stimulus and cause the adaptive modification of a motor behavior.Many elements of this hypothesis have been supported by prior experiments, and correlations have been found [corrected] between complex spikes, simple-spike plasticity and behavior [corrected] during the learning process.We carried out a trial-by-trial analysis of Purkinje cell responses in awake-behaving monkeys and found evidence for a causal role for complex spikes in the induction of cerebellar plasticity during a simple motor learning task.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, Pennsylvania 19104, USA.

ABSTRACT
The hypothesis of cerebellar learning proposes that complex spikes in Purkinje cells engage mechanisms of plasticity in the cerebellar cortex; in turn, changes in the cerebellum depress the simple-spike response of Purkinje cells to a given stimulus and cause the adaptive modification of a motor behavior. Many elements of this hypothesis have been supported by prior experiments, and correlations have been found [corrected] between complex spikes, simple-spike plasticity and behavior [corrected] during the learning process. We carried out a trial-by-trial analysis of Purkinje cell responses in awake-behaving monkeys and found evidence for a causal role for complex spikes in the induction of cerebellar plasticity during a simple motor learning task. We found that the presence of a complex spike on one learning trial was linked to a substantial depression of simple-spike responses on the subsequent trial, at a time when behavioral learning was expressed.

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Effects of learning on responses of one Purkinje cell. From top to bottom, the three rows show the control block, and the learning blocks in the off- and on-direction of the Purkinje cell. In the left column, the colored arrows show different target motions and the black continuous curve shows the direction tuning for the Purkinje cell. The middle and right columns show eye velocity and simple spike firing rate during probe trials. The colors of the traces refer to the different target trajectories indicated by the colored arrows in the polar plots. For ease of comparison, the light blue traces in b and c replot the pre-learning data for downward target motion from a. The ribbons show the mean ±1 SEM of eye velocity and firing rate.
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Figure 2: Effects of learning on responses of one Purkinje cell. From top to bottom, the three rows show the control block, and the learning blocks in the off- and on-direction of the Purkinje cell. In the left column, the colored arrows show different target motions and the black continuous curve shows the direction tuning for the Purkinje cell. The middle and right columns show eye velocity and simple spike firing rate during probe trials. The colors of the traces refer to the different target trajectories indicated by the colored arrows in the polar plots. For ease of comparison, the light blue traces in b and c replot the pre-learning data for downward target motion from a. The ribbons show the mean ±1 SEM of eye velocity and firing rate.

Mentions: Consider a learning experiment on a Purkinje cell with a rightward on-direction, defined by the direction of pursuit associated with the largest simple spike response before learning; the off-direction was leftward. In pre-learning probe trials (Fig. 2a), the Purkinje cell had a relatively small simple spike response during pure downward pursuit (light blue trace), and had larger and smaller simple spike responses, respectively, during pursuit with a small rightward (purple) or leftward (green) component.


Links from complex spikes to local plasticity and motor learning in the cerebellum of awake-behaving monkeys.

Medina JF, Lisberger SG - Nat. Neurosci. (2008)

Effects of learning on responses of one Purkinje cell. From top to bottom, the three rows show the control block, and the learning blocks in the off- and on-direction of the Purkinje cell. In the left column, the colored arrows show different target motions and the black continuous curve shows the direction tuning for the Purkinje cell. The middle and right columns show eye velocity and simple spike firing rate during probe trials. The colors of the traces refer to the different target trajectories indicated by the colored arrows in the polar plots. For ease of comparison, the light blue traces in b and c replot the pre-learning data for downward target motion from a. The ribbons show the mean ±1 SEM of eye velocity and firing rate.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2577564&req=5

Figure 2: Effects of learning on responses of one Purkinje cell. From top to bottom, the three rows show the control block, and the learning blocks in the off- and on-direction of the Purkinje cell. In the left column, the colored arrows show different target motions and the black continuous curve shows the direction tuning for the Purkinje cell. The middle and right columns show eye velocity and simple spike firing rate during probe trials. The colors of the traces refer to the different target trajectories indicated by the colored arrows in the polar plots. For ease of comparison, the light blue traces in b and c replot the pre-learning data for downward target motion from a. The ribbons show the mean ±1 SEM of eye velocity and firing rate.
Mentions: Consider a learning experiment on a Purkinje cell with a rightward on-direction, defined by the direction of pursuit associated with the largest simple spike response before learning; the off-direction was leftward. In pre-learning probe trials (Fig. 2a), the Purkinje cell had a relatively small simple spike response during pure downward pursuit (light blue trace), and had larger and smaller simple spike responses, respectively, during pursuit with a small rightward (purple) or leftward (green) component.

Bottom Line: The hypothesis of cerebellar learning proposes that complex spikes in Purkinje cells engage mechanisms of plasticity in the cerebellar cortex; in turn, changes in the cerebellum depress the simple-spike response of Purkinje cells to a given stimulus and cause the adaptive modification of a motor behavior.Many elements of this hypothesis have been supported by prior experiments, and correlations have been found [corrected] between complex spikes, simple-spike plasticity and behavior [corrected] during the learning process.We carried out a trial-by-trial analysis of Purkinje cell responses in awake-behaving monkeys and found evidence for a causal role for complex spikes in the induction of cerebellar plasticity during a simple motor learning task.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, Pennsylvania 19104, USA.

ABSTRACT
The hypothesis of cerebellar learning proposes that complex spikes in Purkinje cells engage mechanisms of plasticity in the cerebellar cortex; in turn, changes in the cerebellum depress the simple-spike response of Purkinje cells to a given stimulus and cause the adaptive modification of a motor behavior. Many elements of this hypothesis have been supported by prior experiments, and correlations have been found [corrected] between complex spikes, simple-spike plasticity and behavior [corrected] during the learning process. We carried out a trial-by-trial analysis of Purkinje cell responses in awake-behaving monkeys and found evidence for a causal role for complex spikes in the induction of cerebellar plasticity during a simple motor learning task. We found that the presence of a complex spike on one learning trial was linked to a substantial depression of simple-spike responses on the subsequent trial, at a time when behavioral learning was expressed.

Show MeSH
Related in: MedlinePlus