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Prognostic parameters for recurrence of papillary thyroid microcarcinoma.

Kim TY, Hong SJ, Kim JM, Kim WG, Gong G, Ryu JS, Kim WB, Yun SC, Shong YK - BMC Cancer (2008)

Bottom Line: Independent prognostic factors for clinical recurrence of PTMC have not been clearly delineated.Of the 293 patients eligible for analysis, 14 (5%) had recurrence during a median follow-up time of 65 months.Multivariate Cox-regression analysis showed that gender and cervical lymph node metastasis were significant variables PTMC showed very diverse disease extent and could not be regarded as indolent, relatively benign disease based on the primary tumor size.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. tykim@amc.seoul.kr

ABSTRACT

Background: Papillary thyroid microcarcinoma (PTMC) is defined as a papillary thyroid carcinoma less than or equal to 1.0 cm in size. Independent prognostic factors for clinical recurrence of PTMC have not been clearly delineated.

Methods: Clinicopathological parameters predicting PTMC recurrence were determined by retrospective analysis of 307 patients.

Results: Of the 293 patients eligible for analysis, 14 (5%) had recurrence during a median follow-up time of 65 months. Recurrence was observed in 8 of 166 patients (0.5%) treated with total or near-total thyroidectomy; gender (P = 0.02) and presence of lateral cervical node metastases at initial surgery (P = 0.01) were associated with recurrence. Six of the 127 patients (0.5%) treated with hemi- or subtotal thyroidectomy experience recurrences, but no significant prognostic factor for recurrence was identified. Multivariate Cox-regression analysis showed that gender and cervical lymph node metastasis were significant variables

Conclusion: PTMC showed very diverse disease extent and could not be regarded as indolent, relatively benign disease based on the primary tumor size. The extent of surgery should be based on prognostic parameters, such as gender and lateral neck node metastasis, in patients with PTMC.

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Kaplan-Meier curves of disease-free survival according to (A) lymph node metastasis and (B) gender in 127 patients with papillary thyroid microcarcinoma who underwent hemi- or subtotal thyroidectomy.
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Figure 2: Kaplan-Meier curves of disease-free survival according to (A) lymph node metastasis and (B) gender in 127 patients with papillary thyroid microcarcinoma who underwent hemi- or subtotal thyroidectomy.

Mentions: Univariate analysis showed that, in patients who underwent total or near-total thyroidectomy, presence of cervical lymph node metastasis at initial surgery (p = 0.01, Fig. 1A) and gender (p = 0.02, Fig 1B) were significantly associated with clinical recurrence. In patients who underwent partial thyroidectomy, however, there were no significant associations between clinicopathological parameters and clinical recurrence. The Kaplan-Meier estimate curves for cervical lymph node metastasis and gender are shown in Fig. 2A and Fig. 2B, respectively. Amongst the overall patient cohort, regardless of surgical extent, the presence of cervical neck lymph node metastases at initial surgery (p = 0.049) and gender (p = 0.003) were significantly associated with tumor recurrence.


Prognostic parameters for recurrence of papillary thyroid microcarcinoma.

Kim TY, Hong SJ, Kim JM, Kim WG, Gong G, Ryu JS, Kim WB, Yun SC, Shong YK - BMC Cancer (2008)

Kaplan-Meier curves of disease-free survival according to (A) lymph node metastasis and (B) gender in 127 patients with papillary thyroid microcarcinoma who underwent hemi- or subtotal thyroidectomy.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2576338&req=5

Figure 2: Kaplan-Meier curves of disease-free survival according to (A) lymph node metastasis and (B) gender in 127 patients with papillary thyroid microcarcinoma who underwent hemi- or subtotal thyroidectomy.
Mentions: Univariate analysis showed that, in patients who underwent total or near-total thyroidectomy, presence of cervical lymph node metastasis at initial surgery (p = 0.01, Fig. 1A) and gender (p = 0.02, Fig 1B) were significantly associated with clinical recurrence. In patients who underwent partial thyroidectomy, however, there were no significant associations between clinicopathological parameters and clinical recurrence. The Kaplan-Meier estimate curves for cervical lymph node metastasis and gender are shown in Fig. 2A and Fig. 2B, respectively. Amongst the overall patient cohort, regardless of surgical extent, the presence of cervical neck lymph node metastases at initial surgery (p = 0.049) and gender (p = 0.003) were significantly associated with tumor recurrence.

Bottom Line: Independent prognostic factors for clinical recurrence of PTMC have not been clearly delineated.Of the 293 patients eligible for analysis, 14 (5%) had recurrence during a median follow-up time of 65 months.Multivariate Cox-regression analysis showed that gender and cervical lymph node metastasis were significant variables PTMC showed very diverse disease extent and could not be regarded as indolent, relatively benign disease based on the primary tumor size.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. tykim@amc.seoul.kr

ABSTRACT

Background: Papillary thyroid microcarcinoma (PTMC) is defined as a papillary thyroid carcinoma less than or equal to 1.0 cm in size. Independent prognostic factors for clinical recurrence of PTMC have not been clearly delineated.

Methods: Clinicopathological parameters predicting PTMC recurrence were determined by retrospective analysis of 307 patients.

Results: Of the 293 patients eligible for analysis, 14 (5%) had recurrence during a median follow-up time of 65 months. Recurrence was observed in 8 of 166 patients (0.5%) treated with total or near-total thyroidectomy; gender (P = 0.02) and presence of lateral cervical node metastases at initial surgery (P = 0.01) were associated with recurrence. Six of the 127 patients (0.5%) treated with hemi- or subtotal thyroidectomy experience recurrences, but no significant prognostic factor for recurrence was identified. Multivariate Cox-regression analysis showed that gender and cervical lymph node metastasis were significant variables

Conclusion: PTMC showed very diverse disease extent and could not be regarded as indolent, relatively benign disease based on the primary tumor size. The extent of surgery should be based on prognostic parameters, such as gender and lateral neck node metastasis, in patients with PTMC.

Show MeSH
Related in: MedlinePlus