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Stem cells have different needs for REST.

Hermanson O - PLoS Biol. (2008)

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. Ola.Hermanson@ki.se

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A Schematic Summary of Some Cell Type–Specific Roles for RESTRecent reports show a novel role for REST in maintaining ESC phenotype by being a close part of the core transcriptional network of Oct4/Sox2/Nanog in ESCs (see text). REST has previously been suggested to repress neuronal differentiation in NSCs and medulloblastoma cells, in addition to its well-established role in repressing neuronal genes in non-neural cells. REST has also been shown to act as a tumor suppressor by repressing epithelial cell transformation, a role that could be linked to the regulation of cell adhesion genes (see text).
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pbio-0060271-g002: A Schematic Summary of Some Cell Type–Specific Roles for RESTRecent reports show a novel role for REST in maintaining ESC phenotype by being a close part of the core transcriptional network of Oct4/Sox2/Nanog in ESCs (see text). REST has previously been suggested to repress neuronal differentiation in NSCs and medulloblastoma cells, in addition to its well-established role in repressing neuronal genes in non-neural cells. REST has also been shown to act as a tumor suppressor by repressing epithelial cell transformation, a role that could be linked to the regulation of cell adhesion genes (see text).

Mentions: The increased knowledge of the complex nature of the transcriptional regulation by REST has been accompanied by an increasingly more complicated view of the functional roles for REST in physiology and pathology (Figure 2). The perhaps most unexpected finding was the identification of REST as a tumor suppressor in an unbiased screen for suppressors of epithelial cell transformation and thus tumorigenesis [15]. REST had already previously been implicated in tumor biology as an oncogene (http://en.wikipedia.org/wiki/Oncogene) for its ability to repress neuronal genes and thereby presumably repress differentiation of neuroectodermal tumor cells [16].


Stem cells have different needs for REST.

Hermanson O - PLoS Biol. (2008)

A Schematic Summary of Some Cell Type–Specific Roles for RESTRecent reports show a novel role for REST in maintaining ESC phenotype by being a close part of the core transcriptional network of Oct4/Sox2/Nanog in ESCs (see text). REST has previously been suggested to repress neuronal differentiation in NSCs and medulloblastoma cells, in addition to its well-established role in repressing neuronal genes in non-neural cells. REST has also been shown to act as a tumor suppressor by repressing epithelial cell transformation, a role that could be linked to the regulation of cell adhesion genes (see text).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2573942&req=5

pbio-0060271-g002: A Schematic Summary of Some Cell Type–Specific Roles for RESTRecent reports show a novel role for REST in maintaining ESC phenotype by being a close part of the core transcriptional network of Oct4/Sox2/Nanog in ESCs (see text). REST has previously been suggested to repress neuronal differentiation in NSCs and medulloblastoma cells, in addition to its well-established role in repressing neuronal genes in non-neural cells. REST has also been shown to act as a tumor suppressor by repressing epithelial cell transformation, a role that could be linked to the regulation of cell adhesion genes (see text).
Mentions: The increased knowledge of the complex nature of the transcriptional regulation by REST has been accompanied by an increasingly more complicated view of the functional roles for REST in physiology and pathology (Figure 2). The perhaps most unexpected finding was the identification of REST as a tumor suppressor in an unbiased screen for suppressors of epithelial cell transformation and thus tumorigenesis [15]. REST had already previously been implicated in tumor biology as an oncogene (http://en.wikipedia.org/wiki/Oncogene) for its ability to repress neuronal genes and thereby presumably repress differentiation of neuroectodermal tumor cells [16].

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. Ola.Hermanson@ki.se

Show MeSH
Related in: MedlinePlus