Stem cells have different needs for REST.
Affiliation: Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. Ola.Hermanson@ki.seShow MeSH
Related in: MedlinePlus
Mentions: The increased knowledge of the complex nature of the transcriptional regulation by REST has been accompanied by an increasingly more complicated view of the functional roles for REST in physiology and pathology (Figure 2). The perhaps most unexpected finding was the identification of REST as a tumor suppressor in an unbiased screen for suppressors of epithelial cell transformation and thus tumorigenesis . REST had already previously been implicated in tumor biology as an oncogene (http://en.wikipedia.org/wiki/Oncogene) for its ability to repress neuronal genes and thereby presumably repress differentiation of neuroectodermal tumor cells .
Affiliation: Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. Ola.Hermanson@ki.se