Stem cells have different needs for REST.
Affiliation: Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. Ola.Hermanson@ki.seShow MeSH
Mentions: Since its discovery, REST has been the subject of intense research in the fields of developmental biology and transcription. Due to the well-defined RE1 response element and the subsequent identification of numerous endogenous target genes containing this site [6,7], REST proved to be versatile for investigating basic transcriptional mechanisms including more epigenetic mechanisms involving activation or silencing by modification of chromatin proteins (http://en.wikipedia.org/wiki/Chromatin), histones associated with DNA. Soon after the initial reports connecting transcriptional activation with histone acetylation (associated with “open” chromatin and accessible DNA) and transcriptional repression with histone deacetylation (associated with “compact” chromatin and less accessible DNA), the N-terminal repression domain of REST was shown to bind the transcriptional repressor Sin3A and associated histone deacetylases (HDACs) such as HDAC1 and HDAC2 (Figure 1) [8,9].
Affiliation: Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. Ola.Hermanson@ki.se