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Disruption of learned timing in P/Q calcium channel mutants.

Katoh A, Chapman PJ, Raymond JL - PLoS ONE (2008)

Bottom Line: To optimize motor performance, both the amplitude and temporal properties of movements should be modifiable by motor learning.Here we report that the modification of movement timing is highly dependent on signaling through P/Q-type voltage-dependent calcium channels.The results thus demonstrate a distinction between the molecular signaling pathways regulating the timing versus amplitude of movements.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurobiology, Stanford University, Stanford, CA, USA.

ABSTRACT
To optimize motor performance, both the amplitude and temporal properties of movements should be modifiable by motor learning. Here we report that the modification of movement timing is highly dependent on signaling through P/Q-type voltage-dependent calcium channels. Two lines of mutant mice heterozygous for P/Q-type voltage-dependent calcium channels exhibited impaired plasticity of eye movement timing, but relatively intact plasticity of movement amplitude during motor learning in the vestibulo-ocular reflex. The results thus demonstrate a distinction between the molecular signaling pathways regulating the timing versus amplitude of movements.

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Changes in VOR gain and phase in P/Q mutant mice.A) Representative traces illustrating the VOR response to the same head velocity stimulus before (thin lines) and after (thick lines) 30 min of x1/90°lead training in a wild-type mouse (WT: black; same as Fig. 1B), a leaner heterozygous mouse (tgla/+: blue) and an α1A hemizygous mouse (α1A+/−: red). Horizontal calibration bar indicates 500 ms; vertical bar indicates 10°/s for head velocity, 5°/s for eye velocity. Average changes in B) VOR gain and C) VOR phase induced by each visual-vestibular training paradigm in the wild-type mice (abscissa) and the P/Q mutants (ordinate). The training paradigm is indicated by the letter below each set of corresponding data points (a–j, see Table 1). Error bars indicate standard error. See Table 1 for number of animals in each group.
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pone-0003635-g002: Changes in VOR gain and phase in P/Q mutant mice.A) Representative traces illustrating the VOR response to the same head velocity stimulus before (thin lines) and after (thick lines) 30 min of x1/90°lead training in a wild-type mouse (WT: black; same as Fig. 1B), a leaner heterozygous mouse (tgla/+: blue) and an α1A hemizygous mouse (α1A+/−: red). Horizontal calibration bar indicates 500 ms; vertical bar indicates 10°/s for head velocity, 5°/s for eye velocity. Average changes in B) VOR gain and C) VOR phase induced by each visual-vestibular training paradigm in the wild-type mice (abscissa) and the P/Q mutants (ordinate). The training paradigm is indicated by the letter below each set of corresponding data points (a–j, see Table 1). Error bars indicate standard error. See Table 1 for number of animals in each group.

Mentions: Letters a–j for each training paradigm correspond to labels in Figs. 1–3 and Fig. S2. The notation describing each training paradigm denotes the eye movement gain and phase (relative to head motion) that would stabilize the image of the moving visual stimulus on the retina. x1/180°lead training is often referred to as x(−1) training.


Disruption of learned timing in P/Q calcium channel mutants.

Katoh A, Chapman PJ, Raymond JL - PLoS ONE (2008)

Changes in VOR gain and phase in P/Q mutant mice.A) Representative traces illustrating the VOR response to the same head velocity stimulus before (thin lines) and after (thick lines) 30 min of x1/90°lead training in a wild-type mouse (WT: black; same as Fig. 1B), a leaner heterozygous mouse (tgla/+: blue) and an α1A hemizygous mouse (α1A+/−: red). Horizontal calibration bar indicates 500 ms; vertical bar indicates 10°/s for head velocity, 5°/s for eye velocity. Average changes in B) VOR gain and C) VOR phase induced by each visual-vestibular training paradigm in the wild-type mice (abscissa) and the P/Q mutants (ordinate). The training paradigm is indicated by the letter below each set of corresponding data points (a–j, see Table 1). Error bars indicate standard error. See Table 1 for number of animals in each group.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2572847&req=5

pone-0003635-g002: Changes in VOR gain and phase in P/Q mutant mice.A) Representative traces illustrating the VOR response to the same head velocity stimulus before (thin lines) and after (thick lines) 30 min of x1/90°lead training in a wild-type mouse (WT: black; same as Fig. 1B), a leaner heterozygous mouse (tgla/+: blue) and an α1A hemizygous mouse (α1A+/−: red). Horizontal calibration bar indicates 500 ms; vertical bar indicates 10°/s for head velocity, 5°/s for eye velocity. Average changes in B) VOR gain and C) VOR phase induced by each visual-vestibular training paradigm in the wild-type mice (abscissa) and the P/Q mutants (ordinate). The training paradigm is indicated by the letter below each set of corresponding data points (a–j, see Table 1). Error bars indicate standard error. See Table 1 for number of animals in each group.
Mentions: Letters a–j for each training paradigm correspond to labels in Figs. 1–3 and Fig. S2. The notation describing each training paradigm denotes the eye movement gain and phase (relative to head motion) that would stabilize the image of the moving visual stimulus on the retina. x1/180°lead training is often referred to as x(−1) training.

Bottom Line: To optimize motor performance, both the amplitude and temporal properties of movements should be modifiable by motor learning.Here we report that the modification of movement timing is highly dependent on signaling through P/Q-type voltage-dependent calcium channels.The results thus demonstrate a distinction between the molecular signaling pathways regulating the timing versus amplitude of movements.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurobiology, Stanford University, Stanford, CA, USA.

ABSTRACT
To optimize motor performance, both the amplitude and temporal properties of movements should be modifiable by motor learning. Here we report that the modification of movement timing is highly dependent on signaling through P/Q-type voltage-dependent calcium channels. Two lines of mutant mice heterozygous for P/Q-type voltage-dependent calcium channels exhibited impaired plasticity of eye movement timing, but relatively intact plasticity of movement amplitude during motor learning in the vestibulo-ocular reflex. The results thus demonstrate a distinction between the molecular signaling pathways regulating the timing versus amplitude of movements.

Show MeSH