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Brain-derived neurotrophic factor Val66Met and blood glucose: a synergistic effect on memory.

Raz N, Dahle CL, Rodrigue KM, Kennedy KM, Land SJ, Jacobs BS - Front Hum Neurosci (2008)

Bottom Line: Although several genetic variants and vascular risk factors have been linked to mnemonic performance in general and age differences therein, it is unknown whether and how they modify age-related memory declines.The effect on associative memory was stronger than on free recall.These findings indicate that even low-level vascular risk can produce negative cognitive effects in genetically susceptible individuals.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Wayne State University Detroit, MI 48202, USA. nraz@wayne.edu

ABSTRACT
Age-related declines in episodic memory performance are frequently reported, but their mechanisms remain poorly understood. Although several genetic variants and vascular risk factors have been linked to mnemonic performance in general and age differences therein, it is unknown whether and how they modify age-related memory declines. To address that question, we investigated the effect of Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism that affects secretion of BDNF, and fasting blood glucose level (a vascular risk factor) on episodic memory in a sample of healthy volunteers (age 19-77). We found that advanced age and high-normal blood glucose levels were associated with reduced recognition memory for name-face associations and poorer prose recall. However, elevated blood glucose predicted lower memory scores only in carriers of the BDNF 66Met allele. The effect on associative memory was stronger than on free recall. These findings indicate that even low-level vascular risk can produce negative cognitive effects in genetically susceptible individuals. Alleviation of treatable vascular risks in such persons may have a positive effect on age-related cognitive declines.

No MeSH data available.


Related in: MedlinePlus

Name-picture association recognition and blood glucose modified by BDNF Val66Met genotype. BDNF Val66Met Met carriers (red triangles, broken regression line) are compared to BDNF Val homozygotes (black circles, solid regression line). (A) Immediate recognition. (B) Delayed recognition.
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Figure 1: Name-picture association recognition and blood glucose modified by BDNF Val66Met genotype. BDNF Val66Met Met carriers (red triangles, broken regression line) are compared to BDNF Val homozygotes (black circles, solid regression line). (A) Immediate recognition. (B) Delayed recognition.

Mentions: Results of the general linear model analysis are summarized in Table 2. The main effects of age, blood glucose level, and study-test delay were significant. Poorer memory for name-picture associations was linked with older age, higher blood glucose levels, and a delay between study and test. The effect of blood glucose on association memory was modified by significant interactions: BDNF × Glucose and Delay × BDNF × Glucose. The interactions reflected the impact of the BDNF genotype on strength of association between glucose levels and memory. Significant correlations between memory and blood glucose levels were observed only among the BDNF 66Met carriers: r = −0.50 for immediate and r = −0.49 for delayed recognition, both p < 0.001. As is shown in Figure 1, no association between blood glucose and immediate memory score was noted for Val homozygotes: r = 0.14, ns; a trend for delayed recognition was observed: r = −0.25, p < 0.06.


Brain-derived neurotrophic factor Val66Met and blood glucose: a synergistic effect on memory.

Raz N, Dahle CL, Rodrigue KM, Kennedy KM, Land SJ, Jacobs BS - Front Hum Neurosci (2008)

Name-picture association recognition and blood glucose modified by BDNF Val66Met genotype. BDNF Val66Met Met carriers (red triangles, broken regression line) are compared to BDNF Val homozygotes (black circles, solid regression line). (A) Immediate recognition. (B) Delayed recognition.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2572208&req=5

Figure 1: Name-picture association recognition and blood glucose modified by BDNF Val66Met genotype. BDNF Val66Met Met carriers (red triangles, broken regression line) are compared to BDNF Val homozygotes (black circles, solid regression line). (A) Immediate recognition. (B) Delayed recognition.
Mentions: Results of the general linear model analysis are summarized in Table 2. The main effects of age, blood glucose level, and study-test delay were significant. Poorer memory for name-picture associations was linked with older age, higher blood glucose levels, and a delay between study and test. The effect of blood glucose on association memory was modified by significant interactions: BDNF × Glucose and Delay × BDNF × Glucose. The interactions reflected the impact of the BDNF genotype on strength of association between glucose levels and memory. Significant correlations between memory and blood glucose levels were observed only among the BDNF 66Met carriers: r = −0.50 for immediate and r = −0.49 for delayed recognition, both p < 0.001. As is shown in Figure 1, no association between blood glucose and immediate memory score was noted for Val homozygotes: r = 0.14, ns; a trend for delayed recognition was observed: r = −0.25, p < 0.06.

Bottom Line: Although several genetic variants and vascular risk factors have been linked to mnemonic performance in general and age differences therein, it is unknown whether and how they modify age-related memory declines.The effect on associative memory was stronger than on free recall.These findings indicate that even low-level vascular risk can produce negative cognitive effects in genetically susceptible individuals.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Wayne State University Detroit, MI 48202, USA. nraz@wayne.edu

ABSTRACT
Age-related declines in episodic memory performance are frequently reported, but their mechanisms remain poorly understood. Although several genetic variants and vascular risk factors have been linked to mnemonic performance in general and age differences therein, it is unknown whether and how they modify age-related memory declines. To address that question, we investigated the effect of Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism that affects secretion of BDNF, and fasting blood glucose level (a vascular risk factor) on episodic memory in a sample of healthy volunteers (age 19-77). We found that advanced age and high-normal blood glucose levels were associated with reduced recognition memory for name-face associations and poorer prose recall. However, elevated blood glucose predicted lower memory scores only in carriers of the BDNF 66Met allele. The effect on associative memory was stronger than on free recall. These findings indicate that even low-level vascular risk can produce negative cognitive effects in genetically susceptible individuals. Alleviation of treatable vascular risks in such persons may have a positive effect on age-related cognitive declines.

No MeSH data available.


Related in: MedlinePlus