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Isolated metastatic extremity liposarcoma to the liver, an uncommon and transient finding.

Garces CA, Reith JD, Grobmyer SR, Hochwald SN - World J Surg Oncol (2008)

Bottom Line: An extensive evaluation revealed isolated disease to the liver.The lesion was surgically removed with a right hepatic lobectomy and the pathology was consistent with metastatic myxoid/round cell liposarcoma.As expected, the patient experienced progression of disease at sites outside of the liver 5 months after the liver resection.

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Affiliation: Department of Surgery, Division of Surgical Oncology, University of Florida, Gainesville, Florida 32610, USA. christopher.garces@surgery.ufl.edu

ABSTRACT

Background: Extremity liposarcomas can metastasize to different areas of the body but have rarely been demonstrated to metastasize to the liver. Due to the unusual occurrence of isolated metastatic extremity liposarcoma to the liver, the optimal treatment of this condition is unknown.

Case presentation: Less than one year after resection of a myxoid/round cell liposarcoma of the left lateral calf, a 61-year-old male presented with a CT scan showing a 2 cm low-density lesion in the right lobe of the liver. The lesion tripled in size over the next few months. An extensive evaluation revealed isolated disease to the liver. The lesion was surgically removed with a right hepatic lobectomy and the pathology was consistent with metastatic myxoid/round cell liposarcoma.

Conclusion: Although extremity liposarcoma rarely metastasizes solely to the liver, the best chance at cure is with complete resection. Unfortunately, cure rates are very low in the setting of metastatic disease. As expected, the patient experienced progression of disease at sites outside of the liver 5 months after the liver resection.

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Liver resection specimen showing well circumscribed tumor with fat component.
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Figure 5: Liver resection specimen showing well circumscribed tumor with fat component.

Mentions: At laparotomy, ultrasound showed a large mass present in the right lobe of the liver and that the mass splayed the anterior and posterior portal pedicles apart. Next, a standard right hepatic lobectomy was performed with negative margins (Figure 5). A 7.3 × 6.5 × 7.0 cm mass of metastatic myxoid/round cell liposarcoma was present in the liver with histologic features virtually identical to those seen in the calf mass (Figure 6). The patient had an uneventful post-operative course.


Isolated metastatic extremity liposarcoma to the liver, an uncommon and transient finding.

Garces CA, Reith JD, Grobmyer SR, Hochwald SN - World J Surg Oncol (2008)

Liver resection specimen showing well circumscribed tumor with fat component.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2572163&req=5

Figure 5: Liver resection specimen showing well circumscribed tumor with fat component.
Mentions: At laparotomy, ultrasound showed a large mass present in the right lobe of the liver and that the mass splayed the anterior and posterior portal pedicles apart. Next, a standard right hepatic lobectomy was performed with negative margins (Figure 5). A 7.3 × 6.5 × 7.0 cm mass of metastatic myxoid/round cell liposarcoma was present in the liver with histologic features virtually identical to those seen in the calf mass (Figure 6). The patient had an uneventful post-operative course.

Bottom Line: An extensive evaluation revealed isolated disease to the liver.The lesion was surgically removed with a right hepatic lobectomy and the pathology was consistent with metastatic myxoid/round cell liposarcoma.As expected, the patient experienced progression of disease at sites outside of the liver 5 months after the liver resection.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Surgery, Division of Surgical Oncology, University of Florida, Gainesville, Florida 32610, USA. christopher.garces@surgery.ufl.edu

ABSTRACT

Background: Extremity liposarcomas can metastasize to different areas of the body but have rarely been demonstrated to metastasize to the liver. Due to the unusual occurrence of isolated metastatic extremity liposarcoma to the liver, the optimal treatment of this condition is unknown.

Case presentation: Less than one year after resection of a myxoid/round cell liposarcoma of the left lateral calf, a 61-year-old male presented with a CT scan showing a 2 cm low-density lesion in the right lobe of the liver. The lesion tripled in size over the next few months. An extensive evaluation revealed isolated disease to the liver. The lesion was surgically removed with a right hepatic lobectomy and the pathology was consistent with metastatic myxoid/round cell liposarcoma.

Conclusion: Although extremity liposarcoma rarely metastasizes solely to the liver, the best chance at cure is with complete resection. Unfortunately, cure rates are very low in the setting of metastatic disease. As expected, the patient experienced progression of disease at sites outside of the liver 5 months after the liver resection.

Show MeSH
Related in: MedlinePlus