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Factors influencing the participation of gastroenterologists and hepatologists in clinical research.

Dev AT, Kauf TL, Zekry A, Patel K, Heller K, Schulman KA, McHutchison JG - BMC Health Serv Res (2008)

Bottom Line: We surveyed 1050 members of the American Association for the Study of Liver Diseases regarding their participation in clinical research.Barriers to participation were similar between gastroenterologists (n = 160) and hepatologists (n = 189) and between highly experienced (n = 62) and less experienced (n = 159) clinical researchers.These barriers included uncompensated research costs and lack of specialized support.

View Article: PubMed Central - HTML - PubMed

Affiliation: Duke Clinical Research Institute, PO Box 17969, Durham, North Carolina, USA. anouk.dev@med.monash.edu.au

ABSTRACT

Background: Although clinical research is integral to the advancement of medical knowledge, physicians face a variety of obstacles to their participation as investigators in clinical trials. We examined factors that influence the participation of gastroenterologists and hepatologists in clinical research.

Methods: We surveyed 1050 members of the American Association for the Study of Liver Diseases regarding their participation in clinical research. We compared the survey responses by specialty and level of clinical trial experience.

Results: A majority of the respondents (71.6%) reported involvement in research activities. Factors most influential in clinical trial participation included funding and compensation (88.3%) and intellectual pursuit (87.8%). Barriers to participation were similar between gastroenterologists (n = 160) and hepatologists (n = 189) and between highly experienced (n = 62) and less experienced (n = 159) clinical researchers. These barriers included uncompensated research costs and lack of specialized support. Industry marketing was a greater influence among respondents with less trial experience, compared to those with extensive experience (15.7% vs 1.6%; P < .01). Hepatologists and respondents with extensive clinical trial experience tended to be more interested in phase 1 and 2 studies, whereas gastroenterologists and less experienced investigators were more interested in phase 4 studies.

Conclusion: This study suggests that the greatest barrier to participation in clinical research is lack of adequate resources. Respondents also favored industry-sponsored research with less complex trial protocols and studies of relatively short duration.

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Responses to the patient case study.
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Figure 2: Responses to the patient case study.

Mentions: Results from the hypothetical patient enrollment scenarios (Figure 2) are consistent with preferences for shorter trials and concerns about funding noted above. Significantly fewer respondents reported that they would be very or somewhat likely to enroll the patient into trial A, compared to trials B and C (65.6% vs 88.8% vs 87.8%; respectively; P < .001). This pattern was consistent across specialty, current participation in clinical research, and clinical trial experience.


Factors influencing the participation of gastroenterologists and hepatologists in clinical research.

Dev AT, Kauf TL, Zekry A, Patel K, Heller K, Schulman KA, McHutchison JG - BMC Health Serv Res (2008)

Responses to the patient case study.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2572062&req=5

Figure 2: Responses to the patient case study.
Mentions: Results from the hypothetical patient enrollment scenarios (Figure 2) are consistent with preferences for shorter trials and concerns about funding noted above. Significantly fewer respondents reported that they would be very or somewhat likely to enroll the patient into trial A, compared to trials B and C (65.6% vs 88.8% vs 87.8%; respectively; P < .001). This pattern was consistent across specialty, current participation in clinical research, and clinical trial experience.

Bottom Line: We surveyed 1050 members of the American Association for the Study of Liver Diseases regarding their participation in clinical research.Barriers to participation were similar between gastroenterologists (n = 160) and hepatologists (n = 189) and between highly experienced (n = 62) and less experienced (n = 159) clinical researchers.These barriers included uncompensated research costs and lack of specialized support.

View Article: PubMed Central - HTML - PubMed

Affiliation: Duke Clinical Research Institute, PO Box 17969, Durham, North Carolina, USA. anouk.dev@med.monash.edu.au

ABSTRACT

Background: Although clinical research is integral to the advancement of medical knowledge, physicians face a variety of obstacles to their participation as investigators in clinical trials. We examined factors that influence the participation of gastroenterologists and hepatologists in clinical research.

Methods: We surveyed 1050 members of the American Association for the Study of Liver Diseases regarding their participation in clinical research. We compared the survey responses by specialty and level of clinical trial experience.

Results: A majority of the respondents (71.6%) reported involvement in research activities. Factors most influential in clinical trial participation included funding and compensation (88.3%) and intellectual pursuit (87.8%). Barriers to participation were similar between gastroenterologists (n = 160) and hepatologists (n = 189) and between highly experienced (n = 62) and less experienced (n = 159) clinical researchers. These barriers included uncompensated research costs and lack of specialized support. Industry marketing was a greater influence among respondents with less trial experience, compared to those with extensive experience (15.7% vs 1.6%; P < .01). Hepatologists and respondents with extensive clinical trial experience tended to be more interested in phase 1 and 2 studies, whereas gastroenterologists and less experienced investigators were more interested in phase 4 studies.

Conclusion: This study suggests that the greatest barrier to participation in clinical research is lack of adequate resources. Respondents also favored industry-sponsored research with less complex trial protocols and studies of relatively short duration.

Show MeSH
Related in: MedlinePlus