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Factors influencing the participation of gastroenterologists and hepatologists in clinical research.

Dev AT, Kauf TL, Zekry A, Patel K, Heller K, Schulman KA, McHutchison JG - BMC Health Serv Res (2008)

Bottom Line: We surveyed 1050 members of the American Association for the Study of Liver Diseases regarding their participation in clinical research.Barriers to participation were similar between gastroenterologists (n = 160) and hepatologists (n = 189) and between highly experienced (n = 62) and less experienced (n = 159) clinical researchers.These barriers included uncompensated research costs and lack of specialized support.

View Article: PubMed Central - HTML - PubMed

Affiliation: Duke Clinical Research Institute, PO Box 17969, Durham, North Carolina, USA. anouk.dev@med.monash.edu.au

ABSTRACT

Background: Although clinical research is integral to the advancement of medical knowledge, physicians face a variety of obstacles to their participation as investigators in clinical trials. We examined factors that influence the participation of gastroenterologists and hepatologists in clinical research.

Methods: We surveyed 1050 members of the American Association for the Study of Liver Diseases regarding their participation in clinical research. We compared the survey responses by specialty and level of clinical trial experience.

Results: A majority of the respondents (71.6%) reported involvement in research activities. Factors most influential in clinical trial participation included funding and compensation (88.3%) and intellectual pursuit (87.8%). Barriers to participation were similar between gastroenterologists (n = 160) and hepatologists (n = 189) and between highly experienced (n = 62) and less experienced (n = 159) clinical researchers. These barriers included uncompensated research costs and lack of specialized support. Industry marketing was a greater influence among respondents with less trial experience, compared to those with extensive experience (15.7% vs 1.6%; P < .01). Hepatologists and respondents with extensive clinical trial experience tended to be more interested in phase 1 and 2 studies, whereas gastroenterologists and less experienced investigators were more interested in phase 4 studies.

Conclusion: This study suggests that the greatest barrier to participation in clinical research is lack of adequate resources. Respondents also favored industry-sponsored research with less complex trial protocols and studies of relatively short duration.

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Proportion of respondents very likely to enroll patients in cinical research by patient characteristics.
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Figure 1: Proportion of respondents very likely to enroll patients in cinical research by patient characteristics.

Mentions: The perceived ability of the patient to comply with, adhere to, and comprehend protocols was cited by at least 90% of all respondents as extremely or very important in influencing the decision to enroll patients in clinical trials. Cost considerations, either to the patient or the physician, were also frequently cited as factors influencing enrollment. A minority of physicians were likely to enroll patients with high-risk characteristics such as older age, advanced disease, or lack of insurance in clinical trials (Figure 1). Gastroenterologists were more likely than hepatologists to cite logistical considerations (55% vs 43.9%; P < .05) and cost to the patient (85.6% vs 76.2%; P < .05) as affecting patient enrollment decisions.


Factors influencing the participation of gastroenterologists and hepatologists in clinical research.

Dev AT, Kauf TL, Zekry A, Patel K, Heller K, Schulman KA, McHutchison JG - BMC Health Serv Res (2008)

Proportion of respondents very likely to enroll patients in cinical research by patient characteristics.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2572062&req=5

Figure 1: Proportion of respondents very likely to enroll patients in cinical research by patient characteristics.
Mentions: The perceived ability of the patient to comply with, adhere to, and comprehend protocols was cited by at least 90% of all respondents as extremely or very important in influencing the decision to enroll patients in clinical trials. Cost considerations, either to the patient or the physician, were also frequently cited as factors influencing enrollment. A minority of physicians were likely to enroll patients with high-risk characteristics such as older age, advanced disease, or lack of insurance in clinical trials (Figure 1). Gastroenterologists were more likely than hepatologists to cite logistical considerations (55% vs 43.9%; P < .05) and cost to the patient (85.6% vs 76.2%; P < .05) as affecting patient enrollment decisions.

Bottom Line: We surveyed 1050 members of the American Association for the Study of Liver Diseases regarding their participation in clinical research.Barriers to participation were similar between gastroenterologists (n = 160) and hepatologists (n = 189) and between highly experienced (n = 62) and less experienced (n = 159) clinical researchers.These barriers included uncompensated research costs and lack of specialized support.

View Article: PubMed Central - HTML - PubMed

Affiliation: Duke Clinical Research Institute, PO Box 17969, Durham, North Carolina, USA. anouk.dev@med.monash.edu.au

ABSTRACT

Background: Although clinical research is integral to the advancement of medical knowledge, physicians face a variety of obstacles to their participation as investigators in clinical trials. We examined factors that influence the participation of gastroenterologists and hepatologists in clinical research.

Methods: We surveyed 1050 members of the American Association for the Study of Liver Diseases regarding their participation in clinical research. We compared the survey responses by specialty and level of clinical trial experience.

Results: A majority of the respondents (71.6%) reported involvement in research activities. Factors most influential in clinical trial participation included funding and compensation (88.3%) and intellectual pursuit (87.8%). Barriers to participation were similar between gastroenterologists (n = 160) and hepatologists (n = 189) and between highly experienced (n = 62) and less experienced (n = 159) clinical researchers. These barriers included uncompensated research costs and lack of specialized support. Industry marketing was a greater influence among respondents with less trial experience, compared to those with extensive experience (15.7% vs 1.6%; P < .01). Hepatologists and respondents with extensive clinical trial experience tended to be more interested in phase 1 and 2 studies, whereas gastroenterologists and less experienced investigators were more interested in phase 4 studies.

Conclusion: This study suggests that the greatest barrier to participation in clinical research is lack of adequate resources. Respondents also favored industry-sponsored research with less complex trial protocols and studies of relatively short duration.

Show MeSH
Related in: MedlinePlus