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Autoimmunity fought in the cortex

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That essential process, which eliminates autoreactive thymocytes from the get-go, is known to occur in the thymic medulla... To quell that concern, McCaughtry's team generated a transgenic mouse in which the receptors are turned on at the appropriate time... T cells reacting to ubiquitous self-antigens were deleted in the cortex alone, before entering the medulla... Furthermore, the medulla-based transcription factor AIRE, which mediates T cell deletion, did not seem to be required in the cortical deletions... Local dendritic cells, however, were needed... Without them, a large fraction of autoreactive T cell clones survived... The locale of T cell deletion may depend on the antigen involved... Tissue-specific self-antigens are produced only in the medulla, whereas ubiquitous self-antigens, such as house-keeping peptides and the antigen recognized in the authors' mouse model, are widespread and can be handled in the cortex, at the site of first encounter... Now that the question of location has been settled, future studies can focus on learning how cortical dendritic cells control T cells gone awry.

No MeSH data available.


Self-reactive thymocytes (green) are deleted in the cortex (C) before reaching the medulla (M).
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fig1: Self-reactive thymocytes (green) are deleted in the cortex (C) before reaching the medulla (M).


Autoimmunity fought in the cortex
Self-reactive thymocytes (green) are deleted in the cortex (C) before reaching the medulla (M).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2571914&req=5

fig1: Self-reactive thymocytes (green) are deleted in the cortex (C) before reaching the medulla (M).

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

That essential process, which eliminates autoreactive thymocytes from the get-go, is known to occur in the thymic medulla... To quell that concern, McCaughtry's team generated a transgenic mouse in which the receptors are turned on at the appropriate time... T cells reacting to ubiquitous self-antigens were deleted in the cortex alone, before entering the medulla... Furthermore, the medulla-based transcription factor AIRE, which mediates T cell deletion, did not seem to be required in the cortical deletions... Local dendritic cells, however, were needed... Without them, a large fraction of autoreactive T cell clones survived... The locale of T cell deletion may depend on the antigen involved... Tissue-specific self-antigens are produced only in the medulla, whereas ubiquitous self-antigens, such as house-keeping peptides and the antigen recognized in the authors' mouse model, are widespread and can be handled in the cortex, at the site of first encounter... Now that the question of location has been settled, future studies can focus on learning how cortical dendritic cells control T cells gone awry.

No MeSH data available.