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SERENADE: the Study Evaluating Rimonabant Efficacy in Drug-naive Diabetic Patients: effects of monotherapy with rimonabant, the first selective CB1 receptor antagonist, on glycemic control, body weight, and lipid profile in drug-naive type 2 diabetes.

Rosenstock J, Hollander P, Chevalier S, Iranmanesh A, SERENADE Study Gro - Diabetes Care (2008)

Bottom Line: The purpose of this study was to assess the glucose-lowering efficacy and safety of rimonabant monotherapy in drug-naive type 2 diabetic patients.Baseline A1C (7.9%) was reduced by -0.8% with rimonabant versus -0.3% with placebo (Delta A1C -0.51%; P = 0.0002), with a larger rimonabant effect in patients with baseline A1C >or=8.5% (Delta A1C -1.25%; P = 0.0009).Adverse events of interest that occurred more frequently with rimonabant versus placebo were dizziness (10.9 vs. 2.1%), nausea (8.7 vs. 3.6%), anxiety (5.8 vs. 3.6%), depressed mood (5.8 vs. 0.7%), and paresthesia (2.9 vs. 1.4%).

View Article: PubMed Central - PubMed

Affiliation: Dallas Diabetes and Endocrine Center, Dallas, Texas, USA. juliorosenstock@dallasdiabetes.com

ABSTRACT

Objective: The purpose of this study was to assess the glucose-lowering efficacy and safety of rimonabant monotherapy in drug-naive type 2 diabetic patients.

Research design and methods: The Study Evaluating Rimonabant Efficacy in Drug-Naive Diabetic Patients (SERENADE) was a 6-month, randomized, double-blind, placebo-controlled trial of 20 mg/day rimonabant in drug-naive patients with type 2 diabetes (A1C 7-10%). The primary end point was A1C change from baseline; secondary end points included body weight, waist circumference, and lipid profile changes.

Results: A total of 281 patients were randomly assigned; 278 were exposed to treatment, and 236 (84.9%) completed the study. Baseline A1C (7.9%) was reduced by -0.8% with rimonabant versus -0.3% with placebo (Delta A1C -0.51%; P = 0.0002), with a larger rimonabant effect in patients with baseline A1C >or=8.5% (Delta A1C -1.25%; P = 0.0009). Weight loss from baseline was -6.7 kg with rimonabant versus -2.8 kg with placebo (Delta weight -3.8 kg; P < 0.0001). Rimonabant induced improvements from baseline in waist circumference (-6 vs. -2 cm; P < 0.0001), fasting plasma glucose (-0.9 vs. -0.1 mmol/l; P = 0.0012), triglycerides (-16.3 vs. +4.4%; P = 0.0031), and HDL cholesterol (+10.1 vs. +3.2%; P < 0.0001). Adverse events of interest that occurred more frequently with rimonabant versus placebo were dizziness (10.9 vs. 2.1%), nausea (8.7 vs. 3.6%), anxiety (5.8 vs. 3.6%), depressed mood (5.8 vs. 0.7%), and paresthesia (2.9 vs. 1.4%).

Conclusions: Rimonabant monotherapy resulted in meaningful improvements in glycemic control, body weight, and lipid profile in drug-naive type 2 diabetic patients. Further ongoing studies will better establish the benefit-to-risk profile of rimonabant and define its place in type 2 diabetes management.

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Related in: MedlinePlus

Mean (SE) changes from baseline in A1C (A), body weight (B), waist circumference (C), HDL cholesterol (D), triglycerides (E), and adiponectin (F) over 6 months in the intention-to-treat population with last observation carried forward. ○ with dotted line, placebo; • with regular line, rimonabant.
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f1: Mean (SE) changes from baseline in A1C (A), body weight (B), waist circumference (C), HDL cholesterol (D), triglycerides (E), and adiponectin (F) over 6 months in the intention-to-treat population with last observation carried forward. ○ with dotted line, placebo; • with regular line, rimonabant.

Mentions: Mean A1C reduction from baseline was significantly greater with rimonabant versus placebo (−0.8 vs. −0.3%, respectively; P = 0.0002) (Table 2, Fig. 1A). The effect of rimonabant on A1C was more pronounced in a subset of patients with baseline A1C ≥8.5% (−1.9 vs. −0.7%, respectively; P = 0.0009) (Table 2). At study end, more patients receiving rimonabant than patients receiving placebo achieved A1C <7.0% (51 vs. 35%, respectively; P = 0.0122) (Table 2). FPG also improved significantly with rimonabant compared with placebo (Table 2).


SERENADE: the Study Evaluating Rimonabant Efficacy in Drug-naive Diabetic Patients: effects of monotherapy with rimonabant, the first selective CB1 receptor antagonist, on glycemic control, body weight, and lipid profile in drug-naive type 2 diabetes.

Rosenstock J, Hollander P, Chevalier S, Iranmanesh A, SERENADE Study Gro - Diabetes Care (2008)

Mean (SE) changes from baseline in A1C (A), body weight (B), waist circumference (C), HDL cholesterol (D), triglycerides (E), and adiponectin (F) over 6 months in the intention-to-treat population with last observation carried forward. ○ with dotted line, placebo; • with regular line, rimonabant.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2571069&req=5

f1: Mean (SE) changes from baseline in A1C (A), body weight (B), waist circumference (C), HDL cholesterol (D), triglycerides (E), and adiponectin (F) over 6 months in the intention-to-treat population with last observation carried forward. ○ with dotted line, placebo; • with regular line, rimonabant.
Mentions: Mean A1C reduction from baseline was significantly greater with rimonabant versus placebo (−0.8 vs. −0.3%, respectively; P = 0.0002) (Table 2, Fig. 1A). The effect of rimonabant on A1C was more pronounced in a subset of patients with baseline A1C ≥8.5% (−1.9 vs. −0.7%, respectively; P = 0.0009) (Table 2). At study end, more patients receiving rimonabant than patients receiving placebo achieved A1C <7.0% (51 vs. 35%, respectively; P = 0.0122) (Table 2). FPG also improved significantly with rimonabant compared with placebo (Table 2).

Bottom Line: The purpose of this study was to assess the glucose-lowering efficacy and safety of rimonabant monotherapy in drug-naive type 2 diabetic patients.Baseline A1C (7.9%) was reduced by -0.8% with rimonabant versus -0.3% with placebo (Delta A1C -0.51%; P = 0.0002), with a larger rimonabant effect in patients with baseline A1C >or=8.5% (Delta A1C -1.25%; P = 0.0009).Adverse events of interest that occurred more frequently with rimonabant versus placebo were dizziness (10.9 vs. 2.1%), nausea (8.7 vs. 3.6%), anxiety (5.8 vs. 3.6%), depressed mood (5.8 vs. 0.7%), and paresthesia (2.9 vs. 1.4%).

View Article: PubMed Central - PubMed

Affiliation: Dallas Diabetes and Endocrine Center, Dallas, Texas, USA. juliorosenstock@dallasdiabetes.com

ABSTRACT

Objective: The purpose of this study was to assess the glucose-lowering efficacy and safety of rimonabant monotherapy in drug-naive type 2 diabetic patients.

Research design and methods: The Study Evaluating Rimonabant Efficacy in Drug-Naive Diabetic Patients (SERENADE) was a 6-month, randomized, double-blind, placebo-controlled trial of 20 mg/day rimonabant in drug-naive patients with type 2 diabetes (A1C 7-10%). The primary end point was A1C change from baseline; secondary end points included body weight, waist circumference, and lipid profile changes.

Results: A total of 281 patients were randomly assigned; 278 were exposed to treatment, and 236 (84.9%) completed the study. Baseline A1C (7.9%) was reduced by -0.8% with rimonabant versus -0.3% with placebo (Delta A1C -0.51%; P = 0.0002), with a larger rimonabant effect in patients with baseline A1C >or=8.5% (Delta A1C -1.25%; P = 0.0009). Weight loss from baseline was -6.7 kg with rimonabant versus -2.8 kg with placebo (Delta weight -3.8 kg; P < 0.0001). Rimonabant induced improvements from baseline in waist circumference (-6 vs. -2 cm; P < 0.0001), fasting plasma glucose (-0.9 vs. -0.1 mmol/l; P = 0.0012), triglycerides (-16.3 vs. +4.4%; P = 0.0031), and HDL cholesterol (+10.1 vs. +3.2%; P < 0.0001). Adverse events of interest that occurred more frequently with rimonabant versus placebo were dizziness (10.9 vs. 2.1%), nausea (8.7 vs. 3.6%), anxiety (5.8 vs. 3.6%), depressed mood (5.8 vs. 0.7%), and paresthesia (2.9 vs. 1.4%).

Conclusions: Rimonabant monotherapy resulted in meaningful improvements in glycemic control, body weight, and lipid profile in drug-naive type 2 diabetic patients. Further ongoing studies will better establish the benefit-to-risk profile of rimonabant and define its place in type 2 diabetes management.

Show MeSH
Related in: MedlinePlus