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Multiple sublineages of influenza A virus (H5N1), Vietnam, 2005-2007.

Dung Nguyen T, Vinh Nguyen T, Vijaykrishna D, Webster RG, Guan Y, Malik Peiris JS, Smith GJ - Emerging Infect. Dis. (2008)

Bottom Line: Phylogenetic analysis of influenza subtype H5N1 viruses isolated from Vietnam during 2005-2007 shows that multiple sublineages are present in Vietnam.Clade 2.3.4 viruses have replaced clade 1 viruses in northern Vietnam, and clade 1 viruses have been detected in southern Vietnam.Reassortment between these 2 sublineages has also occurred.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Veterinary Research, Hanoi, Vietnam. dzungntd@gmail.com

ABSTRACT
Phylogenetic analysis of influenza subtype H5N1 viruses isolated from Vietnam during 2005-2007 shows that multiple sublineages are present in Vietnam. Clade 2.3.4 viruses have replaced clade 1 viruses in northern Vietnam, and clade 1 viruses have been detected in southern Vietnam. Reassortment between these 2 sublineages has also occurred.

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A) Map of Vietnam showing the location of influenza A virus (H5N1) isolation from 2006 to 2007. B) Phylogenetic relationship of the hemagglutinin (HA) gene of influenza A viruses isolated in Vietnam during 2005–2007. Numbers above and below branches indicate neighbor-joining and Bayesian posterior probabilities, respectively. Analyses were based on nt 1–963 of the HA gene. The HA tree was rooted to swan/Hokkaido/51/96. Numbers to the right of the figure refer to World Health Organization influenza (H5N1) clade designations (Table). Virus names described in this study are shown in colored text; previously described Vietnam isolates are shown in bold italic text. *Denotes viruses with the Ser-123-Pro substitution in the HA. #Denotes a clade 2.3.4 and clade 1 reassortant virus. Scale bar, 0.01 substitutions per site. BHG, bar-headed goose; Ck, chicken; Dk, duck; FJ, Fujian; Gs, goose; GX, Guangxi; GY, Guiyang; HK, Hong Kong Special Administrative Region, People’s Republic of China; HN, Hunan; JX, Jiangxi; IDN, Indonesia; KHM, Cambodia; MusDk, muscovy duck; MYS, Malaysia; NGA, Nigeria; Qa, Quail; ST, Shantou; THA, Thailand; VNM, Vietnam; WDk, wild duck; YN, Yunnan.
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Figure 1: A) Map of Vietnam showing the location of influenza A virus (H5N1) isolation from 2006 to 2007. B) Phylogenetic relationship of the hemagglutinin (HA) gene of influenza A viruses isolated in Vietnam during 2005–2007. Numbers above and below branches indicate neighbor-joining and Bayesian posterior probabilities, respectively. Analyses were based on nt 1–963 of the HA gene. The HA tree was rooted to swan/Hokkaido/51/96. Numbers to the right of the figure refer to World Health Organization influenza (H5N1) clade designations (Table). Virus names described in this study are shown in colored text; previously described Vietnam isolates are shown in bold italic text. *Denotes viruses with the Ser-123-Pro substitution in the HA. #Denotes a clade 2.3.4 and clade 1 reassortant virus. Scale bar, 0.01 substitutions per site. BHG, bar-headed goose; Ck, chicken; Dk, duck; FJ, Fujian; Gs, goose; GX, Guangxi; GY, Guiyang; HK, Hong Kong Special Administrative Region, People’s Republic of China; HN, Hunan; JX, Jiangxi; IDN, Indonesia; KHM, Cambodia; MusDk, muscovy duck; MYS, Malaysia; NGA, Nigeria; Qa, Quail; ST, Shantou; THA, Thailand; VNM, Vietnam; WDk, wild duck; YN, Yunnan.

Mentions: We sequenced the whole genomes of 33 avian influenza virus (H5N1) isolates collected during poultry outbreaks in Vietnam from October 2005 through May 2007. All sequences that were generated in this study have been deposited in GenBank (CY029508–CY029771). The virus was primarily detected in aquatic poultry (ducks, muskovy ducks), but it was also isolated from 2 chickens in December 2006 and January 2007. The date and location of virus isolation are summarized in the Table and Figure 1, panel A.


Multiple sublineages of influenza A virus (H5N1), Vietnam, 2005-2007.

Dung Nguyen T, Vinh Nguyen T, Vijaykrishna D, Webster RG, Guan Y, Malik Peiris JS, Smith GJ - Emerging Infect. Dis. (2008)

A) Map of Vietnam showing the location of influenza A virus (H5N1) isolation from 2006 to 2007. B) Phylogenetic relationship of the hemagglutinin (HA) gene of influenza A viruses isolated in Vietnam during 2005–2007. Numbers above and below branches indicate neighbor-joining and Bayesian posterior probabilities, respectively. Analyses were based on nt 1–963 of the HA gene. The HA tree was rooted to swan/Hokkaido/51/96. Numbers to the right of the figure refer to World Health Organization influenza (H5N1) clade designations (Table). Virus names described in this study are shown in colored text; previously described Vietnam isolates are shown in bold italic text. *Denotes viruses with the Ser-123-Pro substitution in the HA. #Denotes a clade 2.3.4 and clade 1 reassortant virus. Scale bar, 0.01 substitutions per site. BHG, bar-headed goose; Ck, chicken; Dk, duck; FJ, Fujian; Gs, goose; GX, Guangxi; GY, Guiyang; HK, Hong Kong Special Administrative Region, People’s Republic of China; HN, Hunan; JX, Jiangxi; IDN, Indonesia; KHM, Cambodia; MusDk, muscovy duck; MYS, Malaysia; NGA, Nigeria; Qa, Quail; ST, Shantou; THA, Thailand; VNM, Vietnam; WDk, wild duck; YN, Yunnan.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2570938&req=5

Figure 1: A) Map of Vietnam showing the location of influenza A virus (H5N1) isolation from 2006 to 2007. B) Phylogenetic relationship of the hemagglutinin (HA) gene of influenza A viruses isolated in Vietnam during 2005–2007. Numbers above and below branches indicate neighbor-joining and Bayesian posterior probabilities, respectively. Analyses were based on nt 1–963 of the HA gene. The HA tree was rooted to swan/Hokkaido/51/96. Numbers to the right of the figure refer to World Health Organization influenza (H5N1) clade designations (Table). Virus names described in this study are shown in colored text; previously described Vietnam isolates are shown in bold italic text. *Denotes viruses with the Ser-123-Pro substitution in the HA. #Denotes a clade 2.3.4 and clade 1 reassortant virus. Scale bar, 0.01 substitutions per site. BHG, bar-headed goose; Ck, chicken; Dk, duck; FJ, Fujian; Gs, goose; GX, Guangxi; GY, Guiyang; HK, Hong Kong Special Administrative Region, People’s Republic of China; HN, Hunan; JX, Jiangxi; IDN, Indonesia; KHM, Cambodia; MusDk, muscovy duck; MYS, Malaysia; NGA, Nigeria; Qa, Quail; ST, Shantou; THA, Thailand; VNM, Vietnam; WDk, wild duck; YN, Yunnan.
Mentions: We sequenced the whole genomes of 33 avian influenza virus (H5N1) isolates collected during poultry outbreaks in Vietnam from October 2005 through May 2007. All sequences that were generated in this study have been deposited in GenBank (CY029508–CY029771). The virus was primarily detected in aquatic poultry (ducks, muskovy ducks), but it was also isolated from 2 chickens in December 2006 and January 2007. The date and location of virus isolation are summarized in the Table and Figure 1, panel A.

Bottom Line: Phylogenetic analysis of influenza subtype H5N1 viruses isolated from Vietnam during 2005-2007 shows that multiple sublineages are present in Vietnam.Clade 2.3.4 viruses have replaced clade 1 viruses in northern Vietnam, and clade 1 viruses have been detected in southern Vietnam.Reassortment between these 2 sublineages has also occurred.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Veterinary Research, Hanoi, Vietnam. dzungntd@gmail.com

ABSTRACT
Phylogenetic analysis of influenza subtype H5N1 viruses isolated from Vietnam during 2005-2007 shows that multiple sublineages are present in Vietnam. Clade 2.3.4 viruses have replaced clade 1 viruses in northern Vietnam, and clade 1 viruses have been detected in southern Vietnam. Reassortment between these 2 sublineages has also occurred.

Show MeSH
Related in: MedlinePlus