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Hepatitis E, Central African Republic.

Escribà JM, Nakoune E, Recio C, Massamba PM, Matsika-Claquin MD, Goumba C, Rose AM, Nicand E, García E, Leklegban C, Koffi B - Emerging Infect. Dis. (2008)

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: Outbreaks of hepatitis E virus (HEV) have been documented in many geographic regions and nonindustrialized countries ; they have been primarily associated with fecal contamination of drinking water... Of 715 suspected HEV case-patients recorded in the MSF hospital between July 22 and October 25, 2002, 552 (77%) lived in the Begoua commune (271 in the Yembi I neighborhood)... Of 351 suspected case-patients serologically tested for IgG and IgM anti-HEV antibodies, 222 (63%) had IgM antibodies, including 5/16 pregnant women (2.3% of all confirmed cases)... Four of the confirmed case-patients died, a case-fatality ratio (CFR) of 1.8%; one was a pregnant woman (CFR 20% for pregnant women group)... No significant differences were found among confirmed case-patients by sex or age-group... The outbreak was not surprising because a 1995 survey in Bangui showed anti-HEV antibodies in 24% of patients tested, indicating endemic HEV... Our results for IgG-positive patients were similar (23.2% in men and 20.1% in women)... As demonstrated during other outbreaks, we found no significant difference between the distribution of HEV-positive patients by age or sex, although most patients were males (58%) and young adults (71% of ages 14–45 years)... The observed CFR was similar to that in other reported HEV outbreaks, in which CFR varied from 1% to 4%, but it was as high as >30% in pregnant women... We recommended application of preventive measures, including water disinfection, safe disposal of excreta, community health education, and the strengthening of case management and disease surveillance... For the CAR, free access to a safe water supply and drugs was the only way to achieve these goals... The number of HEV cases in the Yembi I neighborhood declined after the crisis team implemented hygienic and chlorination measures in the district, although the number of cases remained constant in other neighborhoods of the commune (Figure)... Definite conclusions cannot be drawn from this finding.

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Suspected cases of hepatitis E virus in Begoua, Central African Republic, by neighborhood, weeks 20–43, 2002. MSF, Médecins san Frontières.
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Figure 1: Suspected cases of hepatitis E virus in Begoua, Central African Republic, by neighborhood, weeks 20–43, 2002. MSF, Médecins san Frontières.

Mentions: Data suggest that the epidemic began in the Yembi I neighborhood, then spread to the rest of the Begoua commune and finally to Bangui or surrounding areas (Figure). Of 715 suspected HEV case-patients recorded in the MSF hospital between July 22 and October 25, 2002, 552 (77%) lived in the Begoua commune (271 in the Yembi I neighborhood). The attack rate for the Begoua commune (20,080 inhabitants) was 2.7%. Of 351 suspected case-patients serologically tested for IgG and IgM anti-HEV antibodies, 222 (63%) had IgM antibodies, including 5/16 pregnant women (2.3% of all confirmed cases). Most patients reported jaundice (97.5%) and choluria (95.1%);other reported symptoms were nausea and vomiting (37.9%), dyspepsia (28.3%), and hepatomegaly and/or splenomegaly (26.4%). Four of the confirmed case-patients died, a case-fatality ratio (CFR) of 1.8%; one was a pregnant woman (CFR 20% for pregnant women group).


Hepatitis E, Central African Republic.

Escribà JM, Nakoune E, Recio C, Massamba PM, Matsika-Claquin MD, Goumba C, Rose AM, Nicand E, García E, Leklegban C, Koffi B - Emerging Infect. Dis. (2008)

Suspected cases of hepatitis E virus in Begoua, Central African Republic, by neighborhood, weeks 20–43, 2002. MSF, Médecins san Frontières.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2570933&req=5

Figure 1: Suspected cases of hepatitis E virus in Begoua, Central African Republic, by neighborhood, weeks 20–43, 2002. MSF, Médecins san Frontières.
Mentions: Data suggest that the epidemic began in the Yembi I neighborhood, then spread to the rest of the Begoua commune and finally to Bangui or surrounding areas (Figure). Of 715 suspected HEV case-patients recorded in the MSF hospital between July 22 and October 25, 2002, 552 (77%) lived in the Begoua commune (271 in the Yembi I neighborhood). The attack rate for the Begoua commune (20,080 inhabitants) was 2.7%. Of 351 suspected case-patients serologically tested for IgG and IgM anti-HEV antibodies, 222 (63%) had IgM antibodies, including 5/16 pregnant women (2.3% of all confirmed cases). Most patients reported jaundice (97.5%) and choluria (95.1%);other reported symptoms were nausea and vomiting (37.9%), dyspepsia (28.3%), and hepatomegaly and/or splenomegaly (26.4%). Four of the confirmed case-patients died, a case-fatality ratio (CFR) of 1.8%; one was a pregnant woman (CFR 20% for pregnant women group).

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

: Outbreaks of hepatitis E virus (HEV) have been documented in many geographic regions and nonindustrialized countries ; they have been primarily associated with fecal contamination of drinking water... Of 715 suspected HEV case-patients recorded in the MSF hospital between July 22 and October 25, 2002, 552 (77%) lived in the Begoua commune (271 in the Yembi I neighborhood)... Of 351 suspected case-patients serologically tested for IgG and IgM anti-HEV antibodies, 222 (63%) had IgM antibodies, including 5/16 pregnant women (2.3% of all confirmed cases)... Four of the confirmed case-patients died, a case-fatality ratio (CFR) of 1.8%; one was a pregnant woman (CFR 20% for pregnant women group)... No significant differences were found among confirmed case-patients by sex or age-group... The outbreak was not surprising because a 1995 survey in Bangui showed anti-HEV antibodies in 24% of patients tested, indicating endemic HEV... Our results for IgG-positive patients were similar (23.2% in men and 20.1% in women)... As demonstrated during other outbreaks, we found no significant difference between the distribution of HEV-positive patients by age or sex, although most patients were males (58%) and young adults (71% of ages 14–45 years)... The observed CFR was similar to that in other reported HEV outbreaks, in which CFR varied from 1% to 4%, but it was as high as >30% in pregnant women... We recommended application of preventive measures, including water disinfection, safe disposal of excreta, community health education, and the strengthening of case management and disease surveillance... For the CAR, free access to a safe water supply and drugs was the only way to achieve these goals... The number of HEV cases in the Yembi I neighborhood declined after the crisis team implemented hygienic and chlorination measures in the district, although the number of cases remained constant in other neighborhoods of the commune (Figure)... Definite conclusions cannot be drawn from this finding.

Show MeSH
Related in: MedlinePlus