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Potential use of antiviral agents in polio eradication.

De Palma AM, Pürstinger G, Wimmer E, Patick AK, Andries K, Rombaut B, De Clercq E, Neyts J - Emerging Infect. Dis. (2008)

Bottom Line: In 1988, the World Health Assembly launched the Global Polio Eradication Initiative, which aimed to use large-scale vaccination with the oral vaccine to eradicate polio worldwide by the year 2000.Also, the current control measures will likely be inadequate to deal with problems that may arise in the postpolio era.A panel convoked by the National Research Council concluded that the use of antiviral drugs may be essential in the polio eradication strategy.

View Article: PubMed Central - PubMed

Affiliation: University of Leuven, Leuven, Belgium.

ABSTRACT
In 1988, the World Health Assembly launched the Global Polio Eradication Initiative, which aimed to use large-scale vaccination with the oral vaccine to eradicate polio worldwide by the year 2000. Although important progress has been made, polio remains endemic in several countries. Also, the current control measures will likely be inadequate to deal with problems that may arise in the postpolio era. A panel convoked by the National Research Council concluded that the use of antiviral drugs may be essential in the polio eradication strategy. We here report on a comparative study of the antipoliovirus activity of a selection of molecules that have previously been reported to be inhibitors of picornavirus replication and discuss their potential use, alone or in combination, for the treatment or prophylaxis of poliovirus infection.

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Structural formulas of selected poliovirus inhibitors. A) Capscid binders; B) protease inhibitors; C) 3A inhibitor; D) nucleoside analogs; E) 2C inhibitors; F) unknown target. HBB, 2-(α-hydroxybenzyl)-benzimidazole.
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Figure 1: Structural formulas of selected poliovirus inhibitors. A) Capscid binders; B) protease inhibitors; C) 3A inhibitor; D) nucleoside analogs; E) 2C inhibitors; F) unknown target. HBB, 2-(α-hydroxybenzyl)-benzimidazole.

Mentions: Because this study was triggered by the recognition that antiviral drugs will be needed in the postvaccination era as a countermeasure against the persistence or reemergence in the environment of vaccine-associated virus, we decided to confine our study to the 3 Sabin strains used for vaccination. The aim was to include compounds that act on different targets in the picornavirus replication cycle (preferably 1 or 2 compounds per target) (Figure 1). When a rather large number of molecules had been described that act through the same target (e.g., for the capsid binding agents), we selected those compounds that were in the most advanced state of development and preferably had been studied in a clinical setting. When only 1 or a few compounds had been described for a particular target (for example, with enviroxime, the sole protein 3A–targeting drug reported so far), the impact in the clinical setting was considered less important. Ribavirin was included as a reference standard, since it was regarded as a broad-spectrum inhibitor of positive-strand RNA viruses.


Potential use of antiviral agents in polio eradication.

De Palma AM, Pürstinger G, Wimmer E, Patick AK, Andries K, Rombaut B, De Clercq E, Neyts J - Emerging Infect. Dis. (2008)

Structural formulas of selected poliovirus inhibitors. A) Capscid binders; B) protease inhibitors; C) 3A inhibitor; D) nucleoside analogs; E) 2C inhibitors; F) unknown target. HBB, 2-(α-hydroxybenzyl)-benzimidazole.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2570929&req=5

Figure 1: Structural formulas of selected poliovirus inhibitors. A) Capscid binders; B) protease inhibitors; C) 3A inhibitor; D) nucleoside analogs; E) 2C inhibitors; F) unknown target. HBB, 2-(α-hydroxybenzyl)-benzimidazole.
Mentions: Because this study was triggered by the recognition that antiviral drugs will be needed in the postvaccination era as a countermeasure against the persistence or reemergence in the environment of vaccine-associated virus, we decided to confine our study to the 3 Sabin strains used for vaccination. The aim was to include compounds that act on different targets in the picornavirus replication cycle (preferably 1 or 2 compounds per target) (Figure 1). When a rather large number of molecules had been described that act through the same target (e.g., for the capsid binding agents), we selected those compounds that were in the most advanced state of development and preferably had been studied in a clinical setting. When only 1 or a few compounds had been described for a particular target (for example, with enviroxime, the sole protein 3A–targeting drug reported so far), the impact in the clinical setting was considered less important. Ribavirin was included as a reference standard, since it was regarded as a broad-spectrum inhibitor of positive-strand RNA viruses.

Bottom Line: In 1988, the World Health Assembly launched the Global Polio Eradication Initiative, which aimed to use large-scale vaccination with the oral vaccine to eradicate polio worldwide by the year 2000.Also, the current control measures will likely be inadequate to deal with problems that may arise in the postpolio era.A panel convoked by the National Research Council concluded that the use of antiviral drugs may be essential in the polio eradication strategy.

View Article: PubMed Central - PubMed

Affiliation: University of Leuven, Leuven, Belgium.

ABSTRACT
In 1988, the World Health Assembly launched the Global Polio Eradication Initiative, which aimed to use large-scale vaccination with the oral vaccine to eradicate polio worldwide by the year 2000. Although important progress has been made, polio remains endemic in several countries. Also, the current control measures will likely be inadequate to deal with problems that may arise in the postpolio era. A panel convoked by the National Research Council concluded that the use of antiviral drugs may be essential in the polio eradication strategy. We here report on a comparative study of the antipoliovirus activity of a selection of molecules that have previously been reported to be inhibitors of picornavirus replication and discuss their potential use, alone or in combination, for the treatment or prophylaxis of poliovirus infection.

Show MeSH
Related in: MedlinePlus