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Neuroinvasion by Mycoplasma pneumoniae in acute disseminated encephalomyelitis.

Stamm B, Moschopulos M, Hungerbuehler H, Guarner J, Genrich GL, Zaki SR - Emerging Infect. Dis. (2008)

Bottom Line: We report the autopsy findings for a 45-year-old man with polyradiculoneuropathy and fatal acute disseminated encephalomyelitis after having Mycoplasma pneumoniae pneumonia.M. pneumoniae antigens were demonstrated by immunohistochemical analysis of brain tissue, indicating neuroinvasion as an additional pathogenetic mechanism in central neurologic complications of M. pneumoniae infection.

View Article: PubMed Central - PubMed

Affiliation: Kantonsspital Aarau, Aarau, Switzerland. stamm@ksa.ch

ABSTRACT
We report the autopsy findings for a 45-year-old man with polyradiculoneuropathy and fatal acute disseminated encephalomyelitis after having Mycoplasma pneumoniae pneumonia. M. pneumoniae antigens were demonstrated by immunohistochemical analysis of brain tissue, indicating neuroinvasion as an additional pathogenetic mechanism in central neurologic complications of M. pneumoniae infection.

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A) Subcortical cerebral white matter with numerous perivascular foci of demyelination and necrosis (hematoxylin and eosin stain, original magnification ×40). B) Immunohistochemical evidence of Mycoplasma pneumoniae antigen inside macrophages present in the perivascular inflammatory infiltrate (immunohistochemical assay performed by using the monoclonal anti–M. pneumoniae antibody and naphthol fast red as counterstain, original magnification ×100).
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Figure 1: A) Subcortical cerebral white matter with numerous perivascular foci of demyelination and necrosis (hematoxylin and eosin stain, original magnification ×40). B) Immunohistochemical evidence of Mycoplasma pneumoniae antigen inside macrophages present in the perivascular inflammatory infiltrate (immunohistochemical assay performed by using the monoclonal anti–M. pneumoniae antibody and naphthol fast red as counterstain, original magnification ×100).

Mentions: Microscopically, most of the hemorrhagic foci in the brain consisted of fibrinoid necrosis of the wall of small veins, surrounded by hemorrhagic parenchymal necrosis and a dense annular infiltrate of neutrophils and macrophages (Figure). In less disease-advanced areas, zones of acute perivascular periaxial demyelination were seen around intact vessels; within these same areas, a few vessels were associated with a sleevelike infiltrate of T lymphocytes and macrophages with no evidence of demyelination or necrosis, which probably represented an earlier stage of the process.


Neuroinvasion by Mycoplasma pneumoniae in acute disseminated encephalomyelitis.

Stamm B, Moschopulos M, Hungerbuehler H, Guarner J, Genrich GL, Zaki SR - Emerging Infect. Dis. (2008)

A) Subcortical cerebral white matter with numerous perivascular foci of demyelination and necrosis (hematoxylin and eosin stain, original magnification ×40). B) Immunohistochemical evidence of Mycoplasma pneumoniae antigen inside macrophages present in the perivascular inflammatory infiltrate (immunohistochemical assay performed by using the monoclonal anti–M. pneumoniae antibody and naphthol fast red as counterstain, original magnification ×100).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2570910&req=5

Figure 1: A) Subcortical cerebral white matter with numerous perivascular foci of demyelination and necrosis (hematoxylin and eosin stain, original magnification ×40). B) Immunohistochemical evidence of Mycoplasma pneumoniae antigen inside macrophages present in the perivascular inflammatory infiltrate (immunohistochemical assay performed by using the monoclonal anti–M. pneumoniae antibody and naphthol fast red as counterstain, original magnification ×100).
Mentions: Microscopically, most of the hemorrhagic foci in the brain consisted of fibrinoid necrosis of the wall of small veins, surrounded by hemorrhagic parenchymal necrosis and a dense annular infiltrate of neutrophils and macrophages (Figure). In less disease-advanced areas, zones of acute perivascular periaxial demyelination were seen around intact vessels; within these same areas, a few vessels were associated with a sleevelike infiltrate of T lymphocytes and macrophages with no evidence of demyelination or necrosis, which probably represented an earlier stage of the process.

Bottom Line: We report the autopsy findings for a 45-year-old man with polyradiculoneuropathy and fatal acute disseminated encephalomyelitis after having Mycoplasma pneumoniae pneumonia.M. pneumoniae antigens were demonstrated by immunohistochemical analysis of brain tissue, indicating neuroinvasion as an additional pathogenetic mechanism in central neurologic complications of M. pneumoniae infection.

View Article: PubMed Central - PubMed

Affiliation: Kantonsspital Aarau, Aarau, Switzerland. stamm@ksa.ch

ABSTRACT
We report the autopsy findings for a 45-year-old man with polyradiculoneuropathy and fatal acute disseminated encephalomyelitis after having Mycoplasma pneumoniae pneumonia. M. pneumoniae antigens were demonstrated by immunohistochemical analysis of brain tissue, indicating neuroinvasion as an additional pathogenetic mechanism in central neurologic complications of M. pneumoniae infection.

Show MeSH
Related in: MedlinePlus