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WU polyomavirus infection in children, Germany.

Neske F, Blessing K, Ullrich F, Pröttel A, Wolfgang Kreth H, Weissbrich B - Emerging Infect. Dis. (2008)

View Article: PubMed Central - PubMed

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To investigate the frequency of WUPyV infections in Germany, we examined nasopharyngeal samples from hospitalized children with acute respiratory diseases for WUPyV DNA... All samples were routinely tested for antigens of adenoviruses, influenza viruses A (fluA) and B, parainfluenza viruses 1–3, and respiratory syncytial virus (RSV) by indirect immunofluorescence assays (Chemicon, Temecula, CA, USA)... During the study period, 1,326 NPA of hospitalized children with febrile respiratory tract diseases were received for viral diagnostic evaluation... Infections with WUPyV were found year round, but most occurred in the winter months... Yearly frequencies (July–June) of WUPyV-positive results varied from 3.2% to 8.5% during the observation period... These variations were not statistically significant... In 34 (54.8%) of the WUPyV-positive samples, co-infections with other respiratory viruses were detected, most frequently with adenovirus (n = 10) and fluA (n = 10), followed by hBoV (n = 9) and RSV (n = 5)... The co-infections included 4 triple infections (2 fluA/hBoV/WUPyV, 1 adenovirus/hBoV/WUPyV, and 1 RSV/hBoV/WUPyV)... In the context of the previous reports of WUPyV detection in Australia and North America, our data suggest a worldwide distribution of WUPyV... Most of the WUPyV-positive children were <4 years of age, and WUPyV DNA was rarely found in children >6 years of age... In keeping with the findings of Gaynor et al., we observed a high number of co-infections... The true number of co-infections in our study is probably higher than the reported 53.2% because we did not test for several respiratory pathogens, such as coronaviruses, rhinoviruses, enteroviruses, and the human metapneumovirus... Hypotheses to account for the detection of WUPyV in respiratory samples include the following: WUPyV is a persisting asymptomatic virus that is detected by chance, WUPyV is a persisting virus that is reactivated by an inflammatory process, or WUPyV is a predisposing or aggravating factor of respiratory diseases.

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Age distribution of children with WU polyomavirus DNA–positive nasopharyngeal aspirates compared with the age distribution of the total study population.
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Figure 1: Age distribution of children with WU polyomavirus DNA–positive nasopharyngeal aspirates compared with the age distribution of the total study population.

Mentions: During the study period, 1,326 NPA of hospitalized children with febrile respiratory tract diseases were received for viral diagnostic evaluation. The median age of the patients was 1.6 years (mean age 3.2 years; range 7 days–22 years), and 58.4% were boys. DNA of 1,277 NPA from 1,085 children was available for retrospective testing. Of these, 62 (4.9%) samples from 59 children were positive by WUPyV PCR and subsequent sequencing. The median age of the WUPyV-positive children was 3.0 years (mean 2.9 years; range 4 months–6.3 years) (Figure), and 57% were boys. Of the children with WUPyV-positive NPA, 3.2% were >6 years of age, although children in this age group constituted 15.7% of the total population. Infections with WUPyV were found year round, but most occurred in the winter months. Yearly frequencies (July–June) of WUPyV-positive results varied from 3.2% to 8.5% during the observation period. These variations were not statistically significant. In 34 (54.8%) of the WUPyV-positive samples, co-infections with other respiratory viruses were detected, most frequently with adenovirus (n = 10) and fluA (n = 10), followed by hBoV (n = 9) and RSV (n = 5). The co-infections included 4 triple infections (2 fluA/hBoV/WUPyV, 1 adenovirus/hBoV/WUPyV, and 1 RSV/hBoV/WUPyV). Clinical data were available for 57 of the 62 WUPyV-positive NPA. A broad spectrum of both upper (45.6%) and lower (54.4%) respiratory tract diseases was observed. The latter included bronchitis, wheezing bronchitis, and pneumonia.


WU polyomavirus infection in children, Germany.

Neske F, Blessing K, Ullrich F, Pröttel A, Wolfgang Kreth H, Weissbrich B - Emerging Infect. Dis. (2008)

Age distribution of children with WU polyomavirus DNA–positive nasopharyngeal aspirates compared with the age distribution of the total study population.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2570908&req=5

Figure 1: Age distribution of children with WU polyomavirus DNA–positive nasopharyngeal aspirates compared with the age distribution of the total study population.
Mentions: During the study period, 1,326 NPA of hospitalized children with febrile respiratory tract diseases were received for viral diagnostic evaluation. The median age of the patients was 1.6 years (mean age 3.2 years; range 7 days–22 years), and 58.4% were boys. DNA of 1,277 NPA from 1,085 children was available for retrospective testing. Of these, 62 (4.9%) samples from 59 children were positive by WUPyV PCR and subsequent sequencing. The median age of the WUPyV-positive children was 3.0 years (mean 2.9 years; range 4 months–6.3 years) (Figure), and 57% were boys. Of the children with WUPyV-positive NPA, 3.2% were >6 years of age, although children in this age group constituted 15.7% of the total population. Infections with WUPyV were found year round, but most occurred in the winter months. Yearly frequencies (July–June) of WUPyV-positive results varied from 3.2% to 8.5% during the observation period. These variations were not statistically significant. In 34 (54.8%) of the WUPyV-positive samples, co-infections with other respiratory viruses were detected, most frequently with adenovirus (n = 10) and fluA (n = 10), followed by hBoV (n = 9) and RSV (n = 5). The co-infections included 4 triple infections (2 fluA/hBoV/WUPyV, 1 adenovirus/hBoV/WUPyV, and 1 RSV/hBoV/WUPyV). Clinical data were available for 57 of the 62 WUPyV-positive NPA. A broad spectrum of both upper (45.6%) and lower (54.4%) respiratory tract diseases was observed. The latter included bronchitis, wheezing bronchitis, and pneumonia.

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

To investigate the frequency of WUPyV infections in Germany, we examined nasopharyngeal samples from hospitalized children with acute respiratory diseases for WUPyV DNA... All samples were routinely tested for antigens of adenoviruses, influenza viruses A (fluA) and B, parainfluenza viruses 1–3, and respiratory syncytial virus (RSV) by indirect immunofluorescence assays (Chemicon, Temecula, CA, USA)... During the study period, 1,326 NPA of hospitalized children with febrile respiratory tract diseases were received for viral diagnostic evaluation... Infections with WUPyV were found year round, but most occurred in the winter months... Yearly frequencies (July–June) of WUPyV-positive results varied from 3.2% to 8.5% during the observation period... These variations were not statistically significant... In 34 (54.8%) of the WUPyV-positive samples, co-infections with other respiratory viruses were detected, most frequently with adenovirus (n = 10) and fluA (n = 10), followed by hBoV (n = 9) and RSV (n = 5)... The co-infections included 4 triple infections (2 fluA/hBoV/WUPyV, 1 adenovirus/hBoV/WUPyV, and 1 RSV/hBoV/WUPyV)... In the context of the previous reports of WUPyV detection in Australia and North America, our data suggest a worldwide distribution of WUPyV... Most of the WUPyV-positive children were <4 years of age, and WUPyV DNA was rarely found in children >6 years of age... In keeping with the findings of Gaynor et al., we observed a high number of co-infections... The true number of co-infections in our study is probably higher than the reported 53.2% because we did not test for several respiratory pathogens, such as coronaviruses, rhinoviruses, enteroviruses, and the human metapneumovirus... Hypotheses to account for the detection of WUPyV in respiratory samples include the following: WUPyV is a persisting asymptomatic virus that is detected by chance, WUPyV is a persisting virus that is reactivated by an inflammatory process, or WUPyV is a predisposing or aggravating factor of respiratory diseases.

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