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Hemorrhagic fever with renal syndrome caused by 2 lineages of Dobrava hantavirus, Russia.

Klempa B, Tkachenko EA, Dzagurova TK, Yunicheva YV, Morozov VG, Okulova NM, Slyusareva GP, Smirnov A, Kruger DH - Emerging Infect. Dis. (2008)

Bottom Line: To determine causative agents, we examined 126 cases of DOBV-associated HFRS in central and southern European Russia.In central Russia (Lipetsk, Voronezh, Orel regions), outbreaks were caused by a DOBV variant (DOBV-Aa) carried by Apodemus agrarius.In southern Russia (Sochi district), where HFRS is endemic, HFRS cases were caused by a new DOBV variant (DOBV-Ap), found in A. ponticus, a novel hantavirus natural host.

View Article: PubMed Central - PubMed

Affiliation: Charité School of Medicine, Berlin, Germany.

ABSTRACT
Dobrava-Belgrade virus (DOBV) is a European hantavirus that causes hemorrhagic fever with renal syndrome (HFRS); case-fatality rates in Balkan countries are as high as 12%. To determine causative agents, we examined 126 cases of DOBV-associated HFRS in central and southern European Russia. In central Russia (Lipetsk, Voronezh, Orel regions), outbreaks were caused by a DOBV variant (DOBV-Aa) carried by Apodemus agrarius. In southern Russia (Sochi district), where HFRS is endemic, HFRS cases were caused by a new DOBV variant (DOBV-Ap), found in A. ponticus, a novel hantavirus natural host. Both viruses, DOBV-Aa/Lipetsk and DOBV-Ap/Sochi, were isolated through Vero E6 cells, genetically characterized, and used for serotyping of the HFRS patients' serum. The clinical severity of HFRS caused by DOBV-Aa resembles that of HFRS caused by Puumala virus (mild to moderate); clinical severity of disease caused by DOBV-Ap infections is more often moderate to severe.

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Map of Europe showing cases, identified by serologic as well as molecular methods, of hemorrhagic fever with renal syndrome caused by infection with the Dobrava-Belgrade virus (DOBV) variants: 1, DOBV-Af; 2, DOBV-Aa ; and 3, DOBV-Ap.
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Figure 3: Map of Europe showing cases, identified by serologic as well as molecular methods, of hemorrhagic fever with renal syndrome caused by infection with the Dobrava-Belgrade virus (DOBV) variants: 1, DOBV-Af; 2, DOBV-Aa ; and 3, DOBV-Ap.

Mentions: Figure 3 shows the regions in Europe where DOBV was demonstrated by serologic as well as molecular analyses to be the causative agent of well-characterized HFRS cases. Region 1 comprises the Balkan area in southeastern Europe where the classic DOBV (our DOBV-Af) was found in A. flavicollis animals as well as in human patients (7,8). Region 2 encompasses northeastern Germany and other regions of central Europe (13,15) as well as the central part of European Russia (this study) where the DOBV-Aa variant from A. agrarius causes mainly mild to moderate HFRS but also severe, life-threatening disease (17). The Sochi region, with its novel animal reservoir of DOBV, A. ponticus, and the DOBV-Ap–associated HFRS cases is marked as region 3. In all these areas, PUUV also circulates as an HFRS agent.


Hemorrhagic fever with renal syndrome caused by 2 lineages of Dobrava hantavirus, Russia.

Klempa B, Tkachenko EA, Dzagurova TK, Yunicheva YV, Morozov VG, Okulova NM, Slyusareva GP, Smirnov A, Kruger DH - Emerging Infect. Dis. (2008)

Map of Europe showing cases, identified by serologic as well as molecular methods, of hemorrhagic fever with renal syndrome caused by infection with the Dobrava-Belgrade virus (DOBV) variants: 1, DOBV-Af; 2, DOBV-Aa ; and 3, DOBV-Ap.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2570905&req=5

Figure 3: Map of Europe showing cases, identified by serologic as well as molecular methods, of hemorrhagic fever with renal syndrome caused by infection with the Dobrava-Belgrade virus (DOBV) variants: 1, DOBV-Af; 2, DOBV-Aa ; and 3, DOBV-Ap.
Mentions: Figure 3 shows the regions in Europe where DOBV was demonstrated by serologic as well as molecular analyses to be the causative agent of well-characterized HFRS cases. Region 1 comprises the Balkan area in southeastern Europe where the classic DOBV (our DOBV-Af) was found in A. flavicollis animals as well as in human patients (7,8). Region 2 encompasses northeastern Germany and other regions of central Europe (13,15) as well as the central part of European Russia (this study) where the DOBV-Aa variant from A. agrarius causes mainly mild to moderate HFRS but also severe, life-threatening disease (17). The Sochi region, with its novel animal reservoir of DOBV, A. ponticus, and the DOBV-Ap–associated HFRS cases is marked as region 3. In all these areas, PUUV also circulates as an HFRS agent.

Bottom Line: To determine causative agents, we examined 126 cases of DOBV-associated HFRS in central and southern European Russia.In central Russia (Lipetsk, Voronezh, Orel regions), outbreaks were caused by a DOBV variant (DOBV-Aa) carried by Apodemus agrarius.In southern Russia (Sochi district), where HFRS is endemic, HFRS cases were caused by a new DOBV variant (DOBV-Ap), found in A. ponticus, a novel hantavirus natural host.

View Article: PubMed Central - PubMed

Affiliation: Charité School of Medicine, Berlin, Germany.

ABSTRACT
Dobrava-Belgrade virus (DOBV) is a European hantavirus that causes hemorrhagic fever with renal syndrome (HFRS); case-fatality rates in Balkan countries are as high as 12%. To determine causative agents, we examined 126 cases of DOBV-associated HFRS in central and southern European Russia. In central Russia (Lipetsk, Voronezh, Orel regions), outbreaks were caused by a DOBV variant (DOBV-Aa) carried by Apodemus agrarius. In southern Russia (Sochi district), where HFRS is endemic, HFRS cases were caused by a new DOBV variant (DOBV-Ap), found in A. ponticus, a novel hantavirus natural host. Both viruses, DOBV-Aa/Lipetsk and DOBV-Ap/Sochi, were isolated through Vero E6 cells, genetically characterized, and used for serotyping of the HFRS patients' serum. The clinical severity of HFRS caused by DOBV-Aa resembles that of HFRS caused by Puumala virus (mild to moderate); clinical severity of disease caused by DOBV-Ap infections is more often moderate to severe.

Show MeSH
Related in: MedlinePlus