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Multicenter cross-sectional study of nontuberculous mycobacterial infections among cystic fibrosis patients, Israel.

Levy I, Grisaru-Soen G, Lerner-Geva L, Kerem E, Blau H, Bentur L, Aviram M, Rivlin J, Picard E, Lavy A, Yahav Y, Rahav G - Emerging Infect. Dis. (2008)

Bottom Line: The study comprised 186 patients whose sputum was analyzed for NTM.The prevalence of NTM isolates was 22.6%, and 6.5% and 10.8% of the patients fulfilled the 1997 and 2007 American Thoracic Society criteria for NTM lung disease, respectively.The incidence of NTM pulmonary infections is increasing among cystic fibrosis patients, reflecting the increase in longevity of such patients as well as environmental exposure to various species of mycobacteria.

View Article: PubMed Central - PubMed

Affiliation: Sheba Medical Center, Tel Hashomer, Israel.

ABSTRACT
This 2-year cross-sectional evaluation of nontuberculous mycobacterial (NTM) infections involved all Israeli medical centers that treat cystic fibrosis patients. The study comprised 186 patients whose sputum was analyzed for NTM. The prevalence of NTM isolates was 22.6%, and 6.5% and 10.8% of the patients fulfilled the 1997 and 2007 American Thoracic Society criteria for NTM lung disease, respectively. Mycobacterium simiae (40.5%), M. abscessus (31.0%), and M. avium complex (14.3%) were the most prevalent. Presence of Aspergillus spp. in sputum and the number of sputum specimens processed for mycobacteria were the most significant predictors for isolation of NTM (odds ratio [OR] = 5.14, 95% confidence interval [CI] 1.87-14.11 and OR = 1.47, 95% CI 1.17-1.85, respectively). The incidence of NTM pulmonary infections is increasing among cystic fibrosis patients, reflecting the increase in longevity of such patients as well as environmental exposure to various species of mycobacteria.

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Different species of nontuberculous mycobacteria isolated from patients with cystic fibrosis (unique patient isolate) in 4 medical centers. M., Mycobacterium.
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Figure 1: Different species of nontuberculous mycobacteria isolated from patients with cystic fibrosis (unique patient isolate) in 4 medical centers. M., Mycobacterium.

Mentions: The prevalence of NTM isolation among CF patients was 22.6% (42/186) (95% confidence interval [CI] 16.2–27.9). The prevalence of NTM varied by geographic location: no NTM were isolated from patients residing in northern Israel (center E, Table 1), whereas the prevalence was 24%–29% in hospitals located in central and southern Israel (centers A, C, D, F, Table 1), (Figure).


Multicenter cross-sectional study of nontuberculous mycobacterial infections among cystic fibrosis patients, Israel.

Levy I, Grisaru-Soen G, Lerner-Geva L, Kerem E, Blau H, Bentur L, Aviram M, Rivlin J, Picard E, Lavy A, Yahav Y, Rahav G - Emerging Infect. Dis. (2008)

Different species of nontuberculous mycobacteria isolated from patients with cystic fibrosis (unique patient isolate) in 4 medical centers. M., Mycobacterium.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2570835&req=5

Figure 1: Different species of nontuberculous mycobacteria isolated from patients with cystic fibrosis (unique patient isolate) in 4 medical centers. M., Mycobacterium.
Mentions: The prevalence of NTM isolation among CF patients was 22.6% (42/186) (95% confidence interval [CI] 16.2–27.9). The prevalence of NTM varied by geographic location: no NTM were isolated from patients residing in northern Israel (center E, Table 1), whereas the prevalence was 24%–29% in hospitals located in central and southern Israel (centers A, C, D, F, Table 1), (Figure).

Bottom Line: The study comprised 186 patients whose sputum was analyzed for NTM.The prevalence of NTM isolates was 22.6%, and 6.5% and 10.8% of the patients fulfilled the 1997 and 2007 American Thoracic Society criteria for NTM lung disease, respectively.The incidence of NTM pulmonary infections is increasing among cystic fibrosis patients, reflecting the increase in longevity of such patients as well as environmental exposure to various species of mycobacteria.

View Article: PubMed Central - PubMed

Affiliation: Sheba Medical Center, Tel Hashomer, Israel.

ABSTRACT
This 2-year cross-sectional evaluation of nontuberculous mycobacterial (NTM) infections involved all Israeli medical centers that treat cystic fibrosis patients. The study comprised 186 patients whose sputum was analyzed for NTM. The prevalence of NTM isolates was 22.6%, and 6.5% and 10.8% of the patients fulfilled the 1997 and 2007 American Thoracic Society criteria for NTM lung disease, respectively. Mycobacterium simiae (40.5%), M. abscessus (31.0%), and M. avium complex (14.3%) were the most prevalent. Presence of Aspergillus spp. in sputum and the number of sputum specimens processed for mycobacteria were the most significant predictors for isolation of NTM (odds ratio [OR] = 5.14, 95% confidence interval [CI] 1.87-14.11 and OR = 1.47, 95% CI 1.17-1.85, respectively). The incidence of NTM pulmonary infections is increasing among cystic fibrosis patients, reflecting the increase in longevity of such patients as well as environmental exposure to various species of mycobacteria.

Show MeSH
Related in: MedlinePlus