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Epidemiology of nontuberculous mycobacteria in patients without HIV infection, New York City.

Bodle EE, Cunningham JA, Della-Latta P, Schluger NW, Saiman L - Emerging Infect. Dis. (2008)

Bottom Line: The difference between demographic characteristics of case-patients in our study (66% female, 61% white, and 59% > 60 years of age) and those of the base population as determined by regional census data was statistically significant.NTM disease in patients without HIV is increasing.Laboratory-based surveillance may be useful for detecting non-MAC and non-respiratory tract disease.

View Article: PubMed Central - PubMed

Affiliation: Columbia University, New York, New York, USA.

ABSTRACT
We reviewed medical records of patients without known HIV and with positive cultures for nontuberculous mycobacteria (NTM) isolated during 2000-2003 from 1 large hospital in New York, New York. Overall, 505 patients had positive NTM cultures; 119 (24%) met the criteria for NTM disease. The difference between demographic characteristics of case-patients in our study (66% female, 61% white, and 59% > 60 years of age) and those of the base population as determined by regional census data was statistically significant. Estimated incidences for positive cultures, all disease, and respiratory tract disease were 17.7, 2.7, and 2.0 per 100,000 persons, respectively. More patients with rapidly growing mycobacteria (61%), Mycobacterium kansasii (70%), or M. marinum (100%) met criteria for disease than did patients with M. avium complex (MAC) (27%, (p < 0.01). NTM disease in patients without HIV is increasing. Laboratory-based surveillance may be useful for detecting non-MAC and non-respiratory tract disease.

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Related in: MedlinePlus

Distribution by sex of patients with positive nontuberculous mycobacteria (NTM) cultures, NTM disease, and disease of the respiratory tract caused by Mycobacterium avium complex (MAC), New York–Presbyterian Hospital, Columbia University Medical Center, 2000–2003, compared with age-adjusted base population from 2000 US Census data.
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Figure 2: Distribution by sex of patients with positive nontuberculous mycobacteria (NTM) cultures, NTM disease, and disease of the respiratory tract caused by Mycobacterium avium complex (MAC), New York–Presbyterian Hospital, Columbia University Medical Center, 2000–2003, compared with age-adjusted base population from 2000 US Census data.

Mentions: By adjusting 2000 US Census data for age, the expected proportion of women in the base population was 57% (Figure 2). The same proportion was observed in patients with NTM-positive cultures (57.0%, 95% CI = 52.6%–61.4%). In contrast, patients with NTM disease were significantly more likely to be female than were those in the base population (66.4%, p = 0.04). Among those with disease of the respiratory tract caused by MAC, the distribution of patients by sex was similar to that of the base population (60.0% female, p = 0.71).


Epidemiology of nontuberculous mycobacteria in patients without HIV infection, New York City.

Bodle EE, Cunningham JA, Della-Latta P, Schluger NW, Saiman L - Emerging Infect. Dis. (2008)

Distribution by sex of patients with positive nontuberculous mycobacteria (NTM) cultures, NTM disease, and disease of the respiratory tract caused by Mycobacterium avium complex (MAC), New York–Presbyterian Hospital, Columbia University Medical Center, 2000–2003, compared with age-adjusted base population from 2000 US Census data.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2570812&req=5

Figure 2: Distribution by sex of patients with positive nontuberculous mycobacteria (NTM) cultures, NTM disease, and disease of the respiratory tract caused by Mycobacterium avium complex (MAC), New York–Presbyterian Hospital, Columbia University Medical Center, 2000–2003, compared with age-adjusted base population from 2000 US Census data.
Mentions: By adjusting 2000 US Census data for age, the expected proportion of women in the base population was 57% (Figure 2). The same proportion was observed in patients with NTM-positive cultures (57.0%, 95% CI = 52.6%–61.4%). In contrast, patients with NTM disease were significantly more likely to be female than were those in the base population (66.4%, p = 0.04). Among those with disease of the respiratory tract caused by MAC, the distribution of patients by sex was similar to that of the base population (60.0% female, p = 0.71).

Bottom Line: The difference between demographic characteristics of case-patients in our study (66% female, 61% white, and 59% > 60 years of age) and those of the base population as determined by regional census data was statistically significant.NTM disease in patients without HIV is increasing.Laboratory-based surveillance may be useful for detecting non-MAC and non-respiratory tract disease.

View Article: PubMed Central - PubMed

Affiliation: Columbia University, New York, New York, USA.

ABSTRACT
We reviewed medical records of patients without known HIV and with positive cultures for nontuberculous mycobacteria (NTM) isolated during 2000-2003 from 1 large hospital in New York, New York. Overall, 505 patients had positive NTM cultures; 119 (24%) met the criteria for NTM disease. The difference between demographic characteristics of case-patients in our study (66% female, 61% white, and 59% > 60 years of age) and those of the base population as determined by regional census data was statistically significant. Estimated incidences for positive cultures, all disease, and respiratory tract disease were 17.7, 2.7, and 2.0 per 100,000 persons, respectively. More patients with rapidly growing mycobacteria (61%), Mycobacterium kansasii (70%), or M. marinum (100%) met criteria for disease than did patients with M. avium complex (MAC) (27%, (p < 0.01). NTM disease in patients without HIV is increasing. Laboratory-based surveillance may be useful for detecting non-MAC and non-respiratory tract disease.

Show MeSH
Related in: MedlinePlus