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Correlation of passivity symptoms and dysfunctional visuomotor action monitoring in psychosis.

Schnell K, Heekeren K, Daumann J, Schnell T, Schnitker R, Möller-Hartmann W, Gouzoulis-Mayfrank E - Brain (2008)

Bottom Line: In the patient group we found the expected correlation of passivity symptoms and visuomotor monitoring performance.A correlation of passivity symptoms with the main experimental effect (actions with -- actions without monitoring) was found in the posterior cingulate cortex (PCC) and in the left IPL.No group differences or group by task interactions were found within the visuomotor-action-monitoring network.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry and Psychotherapy, Division of Medical Psychology, University Hospital of Bonn, Bonn, Germany. knut.schnell@ukb.uni-bonn.de

ABSTRACT
Passivity experiences are hallmark symptoms of schizophrenia that can be characterized by the belief that one's thoughts or actions are controlled by an external agent. It has recently been suggested that these psychotic experiences result from defective monitoring of one's own actions, i.e. disturbed comparison of actions and perceived outcomes. In this study, we examined the function of the previously characterized action monitoring network of the inferior parietal lobule (IPL), medial (mPFC) and lateral prefrontal cortices in patients with different levels of passivity symptoms with an fMRI task. The visuomotor fMRI task demanded control of visually perceived object movements by alternating button presses with the left and the right index finger. In the monitoring condition of this task subjects stopped their actions whenever they detected visuomotor incongruence. fMRI and behavioural data from 15 patients were tested for correlation with passivity symptoms using standardized Scale for Assessment of Positive Symptoms (SAPS)- and AMDP- passivity symptom ratings. Both types of data were tested for differences between the patients group and 15 healthy controls. In the patient group we found the expected correlation of passivity symptoms and visuomotor monitoring performance. There was a significant positive correlation of passivity symptoms with increased latency of incongruence detection and a negative correlation of SAPS-passivity with the number of detected events. fMRI data revealed correlations of passivity symptoms with activation in bilateral IPL, primary motor and sensory cortices in the action monitoring condition. A correlation of passivity symptoms with the main experimental effect (actions with -- actions without monitoring) was found in the posterior cingulate cortex (PCC) and in the left IPL. No group differences or group by task interactions were found within the visuomotor-action-monitoring network. Our results demonstrate the association between passivity symptoms and the dysfunction of visuomotor action monitoring and support the idea that psychotic passivity experiences result from dysfunctions of central action monitoring mechanisms: According to pre-existing concepts of parietal cortex function, IPL-hyperactivation may represent an increase in false detections of visuomotor incongruence while the correlation between passivity and the differential effect of monitoring on PCC-activation assumedly represents greater self-monitoring effort in passivity experiences.

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Experimental Design: MC and CC of the epoch design (E) were based on the same motor task, comprising a simple video game (B). Subjects had to keep a horizontal moving car within the boundaries of a vertically moving curved track by changing its direction with either the right or the left index finger (C). Conditions were indicated by the words ‘Lenken’ (‘steer’) or ‘Prüfen’ (‘verify’) (A). In the MC the computer would take over control of the cars motion reversals a varying number of times during the 30 s MC epochs (E).
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Figure 1: Experimental Design: MC and CC of the epoch design (E) were based on the same motor task, comprising a simple video game (B). Subjects had to keep a horizontal moving car within the boundaries of a vertically moving curved track by changing its direction with either the right or the left index finger (C). Conditions were indicated by the words ‘Lenken’ (‘steer’) or ‘Prüfen’ (‘verify’) (A). In the MC the computer would take over control of the cars motion reversals a varying number of times during the 30 s MC epochs (E).

Mentions: We used a previously reported task (Schnell et al., 2007), which was designed to analyse the monitoring of incongruence between the subjects’ own actions and resulting visual perceptions (Fig. 1). The monitoring condition (MC) and the control condition (CC) were based on the same motor task, comprising a simple video game: subjects had to keep a horizontal moving car within the boundaries of a vertically moving curved track. The horizontal motion of the car was controlled bimanually by pressing a button with either the right or the left index finger alternately. Participants were instructed to steer the car within the boundaries of the track as accurately as possible. On average this challenge demanded a button press every 366 ms. The automatic execution of this motor task was ensured by a preceding training and controlling for movement errors below 5% (percentage of time when the car exceeded the boundaries of the track) in the fMRI experiment.Fig. 1


Correlation of passivity symptoms and dysfunctional visuomotor action monitoring in psychosis.

Schnell K, Heekeren K, Daumann J, Schnell T, Schnitker R, Möller-Hartmann W, Gouzoulis-Mayfrank E - Brain (2008)

Experimental Design: MC and CC of the epoch design (E) were based on the same motor task, comprising a simple video game (B). Subjects had to keep a horizontal moving car within the boundaries of a vertically moving curved track by changing its direction with either the right or the left index finger (C). Conditions were indicated by the words ‘Lenken’ (‘steer’) or ‘Prüfen’ (‘verify’) (A). In the MC the computer would take over control of the cars motion reversals a varying number of times during the 30 s MC epochs (E).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2570714&req=5

Figure 1: Experimental Design: MC and CC of the epoch design (E) were based on the same motor task, comprising a simple video game (B). Subjects had to keep a horizontal moving car within the boundaries of a vertically moving curved track by changing its direction with either the right or the left index finger (C). Conditions were indicated by the words ‘Lenken’ (‘steer’) or ‘Prüfen’ (‘verify’) (A). In the MC the computer would take over control of the cars motion reversals a varying number of times during the 30 s MC epochs (E).
Mentions: We used a previously reported task (Schnell et al., 2007), which was designed to analyse the monitoring of incongruence between the subjects’ own actions and resulting visual perceptions (Fig. 1). The monitoring condition (MC) and the control condition (CC) were based on the same motor task, comprising a simple video game: subjects had to keep a horizontal moving car within the boundaries of a vertically moving curved track. The horizontal motion of the car was controlled bimanually by pressing a button with either the right or the left index finger alternately. Participants were instructed to steer the car within the boundaries of the track as accurately as possible. On average this challenge demanded a button press every 366 ms. The automatic execution of this motor task was ensured by a preceding training and controlling for movement errors below 5% (percentage of time when the car exceeded the boundaries of the track) in the fMRI experiment.Fig. 1

Bottom Line: In the patient group we found the expected correlation of passivity symptoms and visuomotor monitoring performance.A correlation of passivity symptoms with the main experimental effect (actions with -- actions without monitoring) was found in the posterior cingulate cortex (PCC) and in the left IPL.No group differences or group by task interactions were found within the visuomotor-action-monitoring network.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry and Psychotherapy, Division of Medical Psychology, University Hospital of Bonn, Bonn, Germany. knut.schnell@ukb.uni-bonn.de

ABSTRACT
Passivity experiences are hallmark symptoms of schizophrenia that can be characterized by the belief that one's thoughts or actions are controlled by an external agent. It has recently been suggested that these psychotic experiences result from defective monitoring of one's own actions, i.e. disturbed comparison of actions and perceived outcomes. In this study, we examined the function of the previously characterized action monitoring network of the inferior parietal lobule (IPL), medial (mPFC) and lateral prefrontal cortices in patients with different levels of passivity symptoms with an fMRI task. The visuomotor fMRI task demanded control of visually perceived object movements by alternating button presses with the left and the right index finger. In the monitoring condition of this task subjects stopped their actions whenever they detected visuomotor incongruence. fMRI and behavioural data from 15 patients were tested for correlation with passivity symptoms using standardized Scale for Assessment of Positive Symptoms (SAPS)- and AMDP- passivity symptom ratings. Both types of data were tested for differences between the patients group and 15 healthy controls. In the patient group we found the expected correlation of passivity symptoms and visuomotor monitoring performance. There was a significant positive correlation of passivity symptoms with increased latency of incongruence detection and a negative correlation of SAPS-passivity with the number of detected events. fMRI data revealed correlations of passivity symptoms with activation in bilateral IPL, primary motor and sensory cortices in the action monitoring condition. A correlation of passivity symptoms with the main experimental effect (actions with -- actions without monitoring) was found in the posterior cingulate cortex (PCC) and in the left IPL. No group differences or group by task interactions were found within the visuomotor-action-monitoring network. Our results demonstrate the association between passivity symptoms and the dysfunction of visuomotor action monitoring and support the idea that psychotic passivity experiences result from dysfunctions of central action monitoring mechanisms: According to pre-existing concepts of parietal cortex function, IPL-hyperactivation may represent an increase in false detections of visuomotor incongruence while the correlation between passivity and the differential effect of monitoring on PCC-activation assumedly represents greater self-monitoring effort in passivity experiences.

Show MeSH
Related in: MedlinePlus