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Large duodenal GIST with massive liver secondaries melting under Imatinib: a case report.

Sankar S, Subramanian M, Arunkumar T, Venu N, Anand K - Cases J (2008)

Bottom Line: Better understanding of the cell of origin and immunohistochmical markers have made this possible.What is interesting in this case is the enormous tumor load at the time of presentation as exemplified by the cross sectional images.This kind of tumor response and patient survival deserves documentation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Surgical gastroenterology, D-2 Private clinic, Sri Ramachandra Medical College & Research Center, Chennai, 600116, Tamilnadu, India. drsshankar@gmail.com.

ABSTRACT
Gastrointestinal stromal tumors(GIST) have become a well established entity and its taxonomy is no more ambiguous. Better understanding of the cell of origin and immunohistochmical markers have made this possible. Their treatment has been revolutionized with the advent of targeted molecular therapy, namely Imatinib mesylate. Herein we report a rare and interesting case of a thirty year old South Indian Lady with an extremely large Duodenal GIST with massive Liver secondaries. The phenomenon of metastatic GIST responding to Imatinib mesylate is not new. What is interesting in this case is the enormous tumor load at the time of presentation as exemplified by the cross sectional images. This kind of tumor response and patient survival deserves documentation.

No MeSH data available.


Related in: MedlinePlus

Endophytic fleshy tumor of duodenum.
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Figure 1: Endophytic fleshy tumor of duodenum.

Mentions: Thirty year old South Indian Lady, a home maker presented to us in May 2005 with severe anemia and weight loss of three months duration. Her weight was 50 kg and height was 160 cm. She was neither an alcoholic nor a smoker. She had few episodes of malena during this period. She also had abdominal fullness, but no vomiting or pain. Clinical examination revealed a very pale patient with gross hepatomegaly with nodularity suggestive of secondaries Liver. Except for a grossly low hemoglobin, her other hemogram and biochemistry were within normal levels. Esophagogastroduodenoscopy picked up a fleshy protruding tumor in the second part of the duodenum(fig 1). CT abdomen showed a highly vascular and bulky tumor arising from the second part of the duodenum with massive secondary deposits in both the lobes of Liver(fig 2&3). Biopsies were done from the duodenal tumor and Liver metastasis. Histopathological report proved it to be Gastrointestinal stromal tumor(GIST) positive for CD 117.


Large duodenal GIST with massive liver secondaries melting under Imatinib: a case report.

Sankar S, Subramanian M, Arunkumar T, Venu N, Anand K - Cases J (2008)

Endophytic fleshy tumor of duodenum.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2570680&req=5

Figure 1: Endophytic fleshy tumor of duodenum.
Mentions: Thirty year old South Indian Lady, a home maker presented to us in May 2005 with severe anemia and weight loss of three months duration. Her weight was 50 kg and height was 160 cm. She was neither an alcoholic nor a smoker. She had few episodes of malena during this period. She also had abdominal fullness, but no vomiting or pain. Clinical examination revealed a very pale patient with gross hepatomegaly with nodularity suggestive of secondaries Liver. Except for a grossly low hemoglobin, her other hemogram and biochemistry were within normal levels. Esophagogastroduodenoscopy picked up a fleshy protruding tumor in the second part of the duodenum(fig 1). CT abdomen showed a highly vascular and bulky tumor arising from the second part of the duodenum with massive secondary deposits in both the lobes of Liver(fig 2&3). Biopsies were done from the duodenal tumor and Liver metastasis. Histopathological report proved it to be Gastrointestinal stromal tumor(GIST) positive for CD 117.

Bottom Line: Better understanding of the cell of origin and immunohistochmical markers have made this possible.What is interesting in this case is the enormous tumor load at the time of presentation as exemplified by the cross sectional images.This kind of tumor response and patient survival deserves documentation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Surgical gastroenterology, D-2 Private clinic, Sri Ramachandra Medical College & Research Center, Chennai, 600116, Tamilnadu, India. drsshankar@gmail.com.

ABSTRACT
Gastrointestinal stromal tumors(GIST) have become a well established entity and its taxonomy is no more ambiguous. Better understanding of the cell of origin and immunohistochmical markers have made this possible. Their treatment has been revolutionized with the advent of targeted molecular therapy, namely Imatinib mesylate. Herein we report a rare and interesting case of a thirty year old South Indian Lady with an extremely large Duodenal GIST with massive Liver secondaries. The phenomenon of metastatic GIST responding to Imatinib mesylate is not new. What is interesting in this case is the enormous tumor load at the time of presentation as exemplified by the cross sectional images. This kind of tumor response and patient survival deserves documentation.

No MeSH data available.


Related in: MedlinePlus