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Aorta remodeling responses to distinct atherogenic stimuli: hypertension, hypercholesterolemia and turbulent flow/low wall shear stress.

Prado CM, Rossi MA - Open Cardiovasc Med J (2008)

Bottom Line: This review is based on recently published data from our laboratory.We investigated the role of hypertension and laminar flow, hypercholesterolemia and laminar flow and turbulent blood flow/low wall shear stress, and turbulent blood flow/low wall shear stress associated with hypercholesterolemia on aorta remodeling of rats feeding normal diet or hypercholesterolemic diet.Our findings suggest that increased circumferential wall tension due to hypertension plays a key role in the remodeling through biomechanical effects on oxidative stress and increased TGF-beta expression; the remodeling observed in the presence of hypercholesterolemia could be initiated by oxidative stress that is involved in several processes of atherogenesis and this remodeling is more pronounced in the presence of turbulent blood flow/low wall shear stress.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, S.P., Brazil.

ABSTRACT
This review is based on recently published data from our laboratory. We investigated the role of hypertension and laminar flow, hypercholesterolemia and laminar flow and turbulent blood flow/low wall shear stress, and turbulent blood flow/low wall shear stress associated with hypercholesterolemia on aorta remodeling of rats feeding normal diet or hypercholesterolemic diet. Our findings suggest that increased circumferential wall tension due to hypertension plays a key role in the remodeling through biomechanical effects on oxidative stress and increased TGF-beta expression; the remodeling observed in the presence of hypercholesterolemia could be initiated by oxidative stress that is involved in several processes of atherogenesis and this remodeling is more pronounced in the presence of turbulent blood flow/low wall shear stress.

No MeSH data available.


Related in: MedlinePlus

Color Doppler shows a laminar flow in sham-operated groups, the dark red near the aorta wall meaning slower rate of laminar flow.						Color Doppler in operated groups demonstrates a preserved laminar flow in the prestenotic segment and a mixed red, blue, green and yellow						characterizing turbulent flow in the poststenotic segment. (A) Blood flow rate (mL/min). Box and whisker graph shows the batches of data in						sham-operated and operated groups at Day 28 of the experiment. (B) Wall shear stress mean values (dyne/cm2) in aortas from sham-operated						and operated groups at Day 28 of the experiment. (C) Circumferential wall tension (104 dyne/cm) in aortas from sham-operated and operated
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Figure 2: Color Doppler shows a laminar flow in sham-operated groups, the dark red near the aorta wall meaning slower rate of laminar flow. Color Doppler in operated groups demonstrates a preserved laminar flow in the prestenotic segment and a mixed red, blue, green and yellow characterizing turbulent flow in the poststenotic segment. (A) Blood flow rate (mL/min). Box and whisker graph shows the batches of data in sham-operated and operated groups at Day 28 of the experiment. (B) Wall shear stress mean values (dyne/cm2) in aortas from sham-operated and operated groups at Day 28 of the experiment. (C) Circumferential wall tension (104 dyne/cm) in aortas from sham-operated and operated

Mentions: We performed aorta duplex ultrasonography and color Doppler in all groups after 28 days of the surgery of aorta coarctation (n=10 per group). Color Doppler showed a laminar flow in sham-operated and sham-operated+HD aorta and the orange-red color near the aorta wall meaning slower rate of laminar flow. Color Doppler in operated and operated+HD could demonstrate a preserved laminar flow appearing dark-orange to yellow in the prestenotic segment and a mixed of orange-red and blue in the poststenotic segment characterizing turbulent flow (Fig. 2). Blood flow rate in the prestenotic segment was not different among all groups (data not shown). On the other hand, the values in the poststenotic segment were markedly lower in operated and operated+HD in comparison with sham-operated and sham-operated+HD, respectively (Fig. 2A).


Aorta remodeling responses to distinct atherogenic stimuli: hypertension, hypercholesterolemia and turbulent flow/low wall shear stress.

Prado CM, Rossi MA - Open Cardiovasc Med J (2008)

Color Doppler shows a laminar flow in sham-operated groups, the dark red near the aorta wall meaning slower rate of laminar flow.						Color Doppler in operated groups demonstrates a preserved laminar flow in the prestenotic segment and a mixed red, blue, green and yellow						characterizing turbulent flow in the poststenotic segment. (A) Blood flow rate (mL/min). Box and whisker graph shows the batches of data in						sham-operated and operated groups at Day 28 of the experiment. (B) Wall shear stress mean values (dyne/cm2) in aortas from sham-operated						and operated groups at Day 28 of the experiment. (C) Circumferential wall tension (104 dyne/cm) in aortas from sham-operated and operated
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2570580&req=5

Figure 2: Color Doppler shows a laminar flow in sham-operated groups, the dark red near the aorta wall meaning slower rate of laminar flow. Color Doppler in operated groups demonstrates a preserved laminar flow in the prestenotic segment and a mixed red, blue, green and yellow characterizing turbulent flow in the poststenotic segment. (A) Blood flow rate (mL/min). Box and whisker graph shows the batches of data in sham-operated and operated groups at Day 28 of the experiment. (B) Wall shear stress mean values (dyne/cm2) in aortas from sham-operated and operated groups at Day 28 of the experiment. (C) Circumferential wall tension (104 dyne/cm) in aortas from sham-operated and operated
Mentions: We performed aorta duplex ultrasonography and color Doppler in all groups after 28 days of the surgery of aorta coarctation (n=10 per group). Color Doppler showed a laminar flow in sham-operated and sham-operated+HD aorta and the orange-red color near the aorta wall meaning slower rate of laminar flow. Color Doppler in operated and operated+HD could demonstrate a preserved laminar flow appearing dark-orange to yellow in the prestenotic segment and a mixed of orange-red and blue in the poststenotic segment characterizing turbulent flow (Fig. 2). Blood flow rate in the prestenotic segment was not different among all groups (data not shown). On the other hand, the values in the poststenotic segment were markedly lower in operated and operated+HD in comparison with sham-operated and sham-operated+HD, respectively (Fig. 2A).

Bottom Line: This review is based on recently published data from our laboratory.We investigated the role of hypertension and laminar flow, hypercholesterolemia and laminar flow and turbulent blood flow/low wall shear stress, and turbulent blood flow/low wall shear stress associated with hypercholesterolemia on aorta remodeling of rats feeding normal diet or hypercholesterolemic diet.Our findings suggest that increased circumferential wall tension due to hypertension plays a key role in the remodeling through biomechanical effects on oxidative stress and increased TGF-beta expression; the remodeling observed in the presence of hypercholesterolemia could be initiated by oxidative stress that is involved in several processes of atherogenesis and this remodeling is more pronounced in the presence of turbulent blood flow/low wall shear stress.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, S.P., Brazil.

ABSTRACT
This review is based on recently published data from our laboratory. We investigated the role of hypertension and laminar flow, hypercholesterolemia and laminar flow and turbulent blood flow/low wall shear stress, and turbulent blood flow/low wall shear stress associated with hypercholesterolemia on aorta remodeling of rats feeding normal diet or hypercholesterolemic diet. Our findings suggest that increased circumferential wall tension due to hypertension plays a key role in the remodeling through biomechanical effects on oxidative stress and increased TGF-beta expression; the remodeling observed in the presence of hypercholesterolemia could be initiated by oxidative stress that is involved in several processes of atherogenesis and this remodeling is more pronounced in the presence of turbulent blood flow/low wall shear stress.

No MeSH data available.


Related in: MedlinePlus