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Aorta remodeling responses to distinct atherogenic stimuli: hypertension, hypercholesterolemia and turbulent flow/low wall shear stress.

Prado CM, Rossi MA - Open Cardiovasc Med J (2008)

Bottom Line: This review is based on recently published data from our laboratory.We investigated the role of hypertension and laminar flow, hypercholesterolemia and laminar flow and turbulent blood flow/low wall shear stress, and turbulent blood flow/low wall shear stress associated with hypercholesterolemia on aorta remodeling of rats feeding normal diet or hypercholesterolemic diet.Our findings suggest that increased circumferential wall tension due to hypertension plays a key role in the remodeling through biomechanical effects on oxidative stress and increased TGF-beta expression; the remodeling observed in the presence of hypercholesterolemia could be initiated by oxidative stress that is involved in several processes of atherogenesis and this remodeling is more pronounced in the presence of turbulent blood flow/low wall shear stress.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, S.P., Brazil.

ABSTRACT
This review is based on recently published data from our laboratory. We investigated the role of hypertension and laminar flow, hypercholesterolemia and laminar flow and turbulent blood flow/low wall shear stress, and turbulent blood flow/low wall shear stress associated with hypercholesterolemia on aorta remodeling of rats feeding normal diet or hypercholesterolemic diet. Our findings suggest that increased circumferential wall tension due to hypertension plays a key role in the remodeling through biomechanical effects on oxidative stress and increased TGF-beta expression; the remodeling observed in the presence of hypercholesterolemia could be initiated by oxidative stress that is involved in several processes of atherogenesis and this remodeling is more pronounced in the presence of turbulent blood flow/low wall shear stress.

No MeSH data available.


Related in: MedlinePlus

Mean carotid and femoral blood pressures in operated and sham-operated groups during the 28 day period of study. In the operated group, the increase in carotid pressure was progressive after constriction of abdominal aorta. The values of operated+HD group did not differ from sham-operated and sham-operated+HD values, although animals feeding HD have lower levels of arterial blood pressure. On the other hand, the femoral blood pressure was similar in all groups during the experiment.
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Figure 1: Mean carotid and femoral blood pressures in operated and sham-operated groups during the 28 day period of study. In the operated group, the increase in carotid pressure was progressive after constriction of abdominal aorta. The values of operated+HD group did not differ from sham-operated and sham-operated+HD values, although animals feeding HD have lower levels of arterial blood pressure. On the other hand, the femoral blood pressure was similar in all groups during the experiment.

Mentions: The mean arterial blood pressure proximal and distal to the aortic constriction, carotid and femoral pressures, respectively, were obtained in time 0 (before surgery), 24 hours, 14 and 28 days after surgery (n=10 per day and per group). In the operated group, the increase in carotid pressure was progressive after constriction of abdominal aorta. After 24 h, the increase was 7.8% (p>0.05), after 14 days it was 13.2% (p<0.01), and at the end of the experiment, 24.3% (p<0.0001). The values of operated+HD group did not differ from sham-operated and sham-operated+HD values, although animals feeding HD have lower levels of arterial blood pressure. On the other hand, the femoral blood pressure was similar in all groups during the experiment (Fig. 1).


Aorta remodeling responses to distinct atherogenic stimuli: hypertension, hypercholesterolemia and turbulent flow/low wall shear stress.

Prado CM, Rossi MA - Open Cardiovasc Med J (2008)

Mean carotid and femoral blood pressures in operated and sham-operated groups during the 28 day period of study. In the operated group, the increase in carotid pressure was progressive after constriction of abdominal aorta. The values of operated+HD group did not differ from sham-operated and sham-operated+HD values, although animals feeding HD have lower levels of arterial blood pressure. On the other hand, the femoral blood pressure was similar in all groups during the experiment.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2570580&req=5

Figure 1: Mean carotid and femoral blood pressures in operated and sham-operated groups during the 28 day period of study. In the operated group, the increase in carotid pressure was progressive after constriction of abdominal aorta. The values of operated+HD group did not differ from sham-operated and sham-operated+HD values, although animals feeding HD have lower levels of arterial blood pressure. On the other hand, the femoral blood pressure was similar in all groups during the experiment.
Mentions: The mean arterial blood pressure proximal and distal to the aortic constriction, carotid and femoral pressures, respectively, were obtained in time 0 (before surgery), 24 hours, 14 and 28 days after surgery (n=10 per day and per group). In the operated group, the increase in carotid pressure was progressive after constriction of abdominal aorta. After 24 h, the increase was 7.8% (p>0.05), after 14 days it was 13.2% (p<0.01), and at the end of the experiment, 24.3% (p<0.0001). The values of operated+HD group did not differ from sham-operated and sham-operated+HD values, although animals feeding HD have lower levels of arterial blood pressure. On the other hand, the femoral blood pressure was similar in all groups during the experiment (Fig. 1).

Bottom Line: This review is based on recently published data from our laboratory.We investigated the role of hypertension and laminar flow, hypercholesterolemia and laminar flow and turbulent blood flow/low wall shear stress, and turbulent blood flow/low wall shear stress associated with hypercholesterolemia on aorta remodeling of rats feeding normal diet or hypercholesterolemic diet.Our findings suggest that increased circumferential wall tension due to hypertension plays a key role in the remodeling through biomechanical effects on oxidative stress and increased TGF-beta expression; the remodeling observed in the presence of hypercholesterolemia could be initiated by oxidative stress that is involved in several processes of atherogenesis and this remodeling is more pronounced in the presence of turbulent blood flow/low wall shear stress.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, S.P., Brazil.

ABSTRACT
This review is based on recently published data from our laboratory. We investigated the role of hypertension and laminar flow, hypercholesterolemia and laminar flow and turbulent blood flow/low wall shear stress, and turbulent blood flow/low wall shear stress associated with hypercholesterolemia on aorta remodeling of rats feeding normal diet or hypercholesterolemic diet. Our findings suggest that increased circumferential wall tension due to hypertension plays a key role in the remodeling through biomechanical effects on oxidative stress and increased TGF-beta expression; the remodeling observed in the presence of hypercholesterolemia could be initiated by oxidative stress that is involved in several processes of atherogenesis and this remodeling is more pronounced in the presence of turbulent blood flow/low wall shear stress.

No MeSH data available.


Related in: MedlinePlus