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Nuclear hBD-1 accumulation in malignant salivary gland tumours.

Wenghoefer M, Pantelis A, Dommisch H, Götz W, Reich R, Bergé S, Martini M, Allam JP, Jepsen S, Merkelbach-Bruse S, Fischer HP, Novak N, Winter J - BMC Cancer (2008)

Bottom Line: Whereas the antimicrobial peptides hBD-2 and -3 are related to inflammation, the constitutively expressed hBD-1 might function as 8p tumour suppressor gene and thus play a key role in control of transcription and induction of apoptosis in malignant epithelial tumours.Pleomorphic adenomas showed cytoplasmic as well as weak nuclear hBD-1 staining.In pleomorphic adenomas hBD-1 might be connected to their biologic behaviour of recurrence and malignant transformation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Oral & Maxillofacial Plastic Surgery, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. m.wenghoefer@gmx.de

ABSTRACT

Background: Whereas the antimicrobial peptides hBD-2 and -3 are related to inflammation, the constitutively expressed hBD-1 might function as 8p tumour suppressor gene and thus play a key role in control of transcription and induction of apoptosis in malignant epithelial tumours. Therefore this study was conducted to characterise proteins involved in cell cycle control and host defence in different benign and malignant salivary gland tumours in comparison with healthy salivary gland tissue.

Methods: 21 paraffin-embedded tissue samples of benign (n = 7), and malignant (n = 7) salivary gland tumours as well as healthy (n = 7) salivary glands were examined immunohistochemically for the expression of p53, bcl-2, and hBD-1, -2, -3.

Results: HBD-1 was distributed in the cytoplasm of healthy salivary glands and benign salivary gland tumours but seems to migrate into the nucleus of malignant salivary gland tumours. Pleomorphic adenomas showed cytoplasmic as well as weak nuclear hBD-1 staining.

Conclusion: HBD-1, 2 and 3 are traceable in healthy salivary gland tissue as well as in benign and malignant salivary gland tumours. As hBD-1 is shifted from the cytoplasm to the nucleus in malignant salivary gland tumours, we hypothesize that it might play a role in the oncogenesis of these tumours. In pleomorphic adenomas hBD-1 might be connected to their biologic behaviour of recurrence and malignant transformation.

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Nuclear and cytoplasmatic hBD-1 staining in a pleomorphic adenoma.
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Figure 4: Nuclear and cytoplasmatic hBD-1 staining in a pleomorphic adenoma.

Mentions: Fig. 1 shows the typical hBD-1 staining in an adenoid cystic carcinoma in comparison with healthy salivary gland tissue (fusion figure). Fig. 2 shows hBD-2 and Fig. 3 shows hBD-3 staining in adenoid cystic carcinomas (below) in comparison with healthy salivary gland tissue (above). Fig. 4 shows nuclear and cytoplasmatic hBD-1 staining in a pleomorphic adenoma.


Nuclear hBD-1 accumulation in malignant salivary gland tumours.

Wenghoefer M, Pantelis A, Dommisch H, Götz W, Reich R, Bergé S, Martini M, Allam JP, Jepsen S, Merkelbach-Bruse S, Fischer HP, Novak N, Winter J - BMC Cancer (2008)

Nuclear and cytoplasmatic hBD-1 staining in a pleomorphic adenoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2567991&req=5

Figure 4: Nuclear and cytoplasmatic hBD-1 staining in a pleomorphic adenoma.
Mentions: Fig. 1 shows the typical hBD-1 staining in an adenoid cystic carcinoma in comparison with healthy salivary gland tissue (fusion figure). Fig. 2 shows hBD-2 and Fig. 3 shows hBD-3 staining in adenoid cystic carcinomas (below) in comparison with healthy salivary gland tissue (above). Fig. 4 shows nuclear and cytoplasmatic hBD-1 staining in a pleomorphic adenoma.

Bottom Line: Whereas the antimicrobial peptides hBD-2 and -3 are related to inflammation, the constitutively expressed hBD-1 might function as 8p tumour suppressor gene and thus play a key role in control of transcription and induction of apoptosis in malignant epithelial tumours.Pleomorphic adenomas showed cytoplasmic as well as weak nuclear hBD-1 staining.In pleomorphic adenomas hBD-1 might be connected to their biologic behaviour of recurrence and malignant transformation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Oral & Maxillofacial Plastic Surgery, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. m.wenghoefer@gmx.de

ABSTRACT

Background: Whereas the antimicrobial peptides hBD-2 and -3 are related to inflammation, the constitutively expressed hBD-1 might function as 8p tumour suppressor gene and thus play a key role in control of transcription and induction of apoptosis in malignant epithelial tumours. Therefore this study was conducted to characterise proteins involved in cell cycle control and host defence in different benign and malignant salivary gland tumours in comparison with healthy salivary gland tissue.

Methods: 21 paraffin-embedded tissue samples of benign (n = 7), and malignant (n = 7) salivary gland tumours as well as healthy (n = 7) salivary glands were examined immunohistochemically for the expression of p53, bcl-2, and hBD-1, -2, -3.

Results: HBD-1 was distributed in the cytoplasm of healthy salivary glands and benign salivary gland tumours but seems to migrate into the nucleus of malignant salivary gland tumours. Pleomorphic adenomas showed cytoplasmic as well as weak nuclear hBD-1 staining.

Conclusion: HBD-1, 2 and 3 are traceable in healthy salivary gland tissue as well as in benign and malignant salivary gland tumours. As hBD-1 is shifted from the cytoplasm to the nucleus in malignant salivary gland tumours, we hypothesize that it might play a role in the oncogenesis of these tumours. In pleomorphic adenomas hBD-1 might be connected to their biologic behaviour of recurrence and malignant transformation.

Show MeSH
Related in: MedlinePlus