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Unusual histological presentation in neurofibromas: Two case reports.

Joshi D, Gangane N, Kishore S, Vagha S - Cases J (2008)

Bottom Line: The objective of this paper is to discuss the unusual histological findings seen in two cases of neurofibromas associated with neurofibromatosis type 1 Both cases presented with multiple subcutaneous nodules.Histological examination of case no.1 revealed a benign tumor of the peripheral nerve sheath, of neurofibroma type with presence of mucus producing glands.The epithelial component was benign in this case.

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Affiliation: Department of Pathology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India. nitingangane@rediffmail.com.

ABSTRACT
Various histological variants of neurofibroma have been described. The objective of this paper is to discuss the unusual histological findings seen in two cases of neurofibromas associated with neurofibromatosis type 1 Both cases presented with multiple subcutaneous nodules. Surgical excision of the largest nodule was done in both the cases. Histological examination of case no.1 revealed a benign tumor of the peripheral nerve sheath, of neurofibroma type with presence of mucus producing glands. The epithelial component was benign in this case. The second case showed presence of rosettes in between areas of typical neurofibroma.

No MeSH data available.


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(a): Section shows slender spindle shaped cells embedded in a collagenous stroma along with presence of mucus producing glands. (H&E ×100) (b): Glands are lined by goblet cells and show presence of intraluminal mucin. (H&E ×400).
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Figure 1: (a): Section shows slender spindle shaped cells embedded in a collagenous stroma along with presence of mucus producing glands. (H&E ×100) (b): Glands are lined by goblet cells and show presence of intraluminal mucin. (H&E ×400).

Mentions: Microscopic examination showed presence of tumor consisting of spindle cells having slender, curved, often wavy nuclei embedded in a collagenous stroma. Cytoplasm of these cells was indistinct and nuclear pleomorphism or mitotic figures were not present. These cells were also seen arranged in interlacing bundles but no nuclear palisading or Antoni A/B areas were demonstrated. Tumor also showed presence of mucus producing glands lined by a single layer of benign tall columnar epithelial cells with basally located nuclei and abundant clear cytoplasm (Figure 1). A diagnosis of benign glandular peripheral nerve sheath tumor (PNST or glandular neurofibroma) was given.


Unusual histological presentation in neurofibromas: Two case reports.

Joshi D, Gangane N, Kishore S, Vagha S - Cases J (2008)

(a): Section shows slender spindle shaped cells embedded in a collagenous stroma along with presence of mucus producing glands. (H&E ×100) (b): Glands are lined by goblet cells and show presence of intraluminal mucin. (H&E ×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2565668&req=5

Figure 1: (a): Section shows slender spindle shaped cells embedded in a collagenous stroma along with presence of mucus producing glands. (H&E ×100) (b): Glands are lined by goblet cells and show presence of intraluminal mucin. (H&E ×400).
Mentions: Microscopic examination showed presence of tumor consisting of spindle cells having slender, curved, often wavy nuclei embedded in a collagenous stroma. Cytoplasm of these cells was indistinct and nuclear pleomorphism or mitotic figures were not present. These cells were also seen arranged in interlacing bundles but no nuclear palisading or Antoni A/B areas were demonstrated. Tumor also showed presence of mucus producing glands lined by a single layer of benign tall columnar epithelial cells with basally located nuclei and abundant clear cytoplasm (Figure 1). A diagnosis of benign glandular peripheral nerve sheath tumor (PNST or glandular neurofibroma) was given.

Bottom Line: The objective of this paper is to discuss the unusual histological findings seen in two cases of neurofibromas associated with neurofibromatosis type 1 Both cases presented with multiple subcutaneous nodules.Histological examination of case no.1 revealed a benign tumor of the peripheral nerve sheath, of neurofibroma type with presence of mucus producing glands.The epithelial component was benign in this case.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India. nitingangane@rediffmail.com.

ABSTRACT
Various histological variants of neurofibroma have been described. The objective of this paper is to discuss the unusual histological findings seen in two cases of neurofibromas associated with neurofibromatosis type 1 Both cases presented with multiple subcutaneous nodules. Surgical excision of the largest nodule was done in both the cases. Histological examination of case no.1 revealed a benign tumor of the peripheral nerve sheath, of neurofibroma type with presence of mucus producing glands. The epithelial component was benign in this case. The second case showed presence of rosettes in between areas of typical neurofibroma.

No MeSH data available.


Related in: MedlinePlus