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Locally relapsed and metastatic uterine leiomyoma: a case report.

Londero AP, Perego P, Mangioni C, Lellé RJ, Londero F, Marchesoni D - J Med Case Rep (2008)

Bottom Line: It presents as either a singular nodule or multiple nodules of proliferating smooth muscle cells and is generally found in the lungs of women who have undergone a hysterectomy.The role of chemoprophylaxis in preventing future recurrences remains unclear.The use of progesterone as an adjuvant therapy for benign metastasising leiomyoma could simply be palliative, with associated psychological benefits, or it could be of therapeutic significance.

View Article: PubMed Central - HTML - PubMed

Affiliation: Clinica di Ginecologia ed Ostetricia, University of Udine, piazzale SM della Misericordia, Udine, Italy. ambrogio.londero@gmail.com

ABSTRACT

Introduction: Benign metastasising leiomyoma refers to a type of lesion characterised by leiomyomatous alterations without any indication of malignancy. It presents as either a singular nodule or multiple nodules of proliferating smooth muscle cells and is generally found in the lungs of women who have undergone a hysterectomy. The purpose of this case report is to contribute to the knowledge of this rare disease by presenting evidence and experience of a patient case. In particular, this report seeks to investigate the therapeutic approaches in order to understand whether a standard of care can be prescribed and whether the use of prophylaxis therapy with progesterone as a follow-up to surgery serves as a reasonable treatment in certain cases diagnosed as benign metastasising leiomyoma.

Case presentation: We present the case of a 52-year-old Caucasian woman who developed a pelvic relapse and a pulmonary localisation of benign metastasising leiomyoma following a hysterectomy for myomatous uterus.

Conclusion: Our literature review revealed a single case of the use of chemoprophylaxis as treatment of a benign metastasising leiomyoma. The role of chemoprophylaxis in preventing future recurrences remains unclear. The use of progesterone as an adjuvant therapy for benign metastasising leiomyoma could simply be palliative, with associated psychological benefits, or it could be of therapeutic significance.

No MeSH data available.


Related in: MedlinePlus

Computed tomography scan of the thorax showing single nodular mass in the right lung of about 4 cm in diameter, evident 1 year after the pelvic recurrence resection.
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Figure 4: Computed tomography scan of the thorax showing single nodular mass in the right lung of about 4 cm in diameter, evident 1 year after the pelvic recurrence resection.

Mentions: A routine chest X-ray the following year, in May 2005, showed a nodular posterior basal density in the right lung of about 4 cm in diameter. The presence of a single nodular mass was confirmed at CT scan of the thorax (Figure 4). At this point, a second PET-CT total body scan was performed, showing a pulmonary lesion with a low metabolic gradient, as is consistent with a benign lesion.


Locally relapsed and metastatic uterine leiomyoma: a case report.

Londero AP, Perego P, Mangioni C, Lellé RJ, Londero F, Marchesoni D - J Med Case Rep (2008)

Computed tomography scan of the thorax showing single nodular mass in the right lung of about 4 cm in diameter, evident 1 year after the pelvic recurrence resection.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2563016&req=5

Figure 4: Computed tomography scan of the thorax showing single nodular mass in the right lung of about 4 cm in diameter, evident 1 year after the pelvic recurrence resection.
Mentions: A routine chest X-ray the following year, in May 2005, showed a nodular posterior basal density in the right lung of about 4 cm in diameter. The presence of a single nodular mass was confirmed at CT scan of the thorax (Figure 4). At this point, a second PET-CT total body scan was performed, showing a pulmonary lesion with a low metabolic gradient, as is consistent with a benign lesion.

Bottom Line: It presents as either a singular nodule or multiple nodules of proliferating smooth muscle cells and is generally found in the lungs of women who have undergone a hysterectomy.The role of chemoprophylaxis in preventing future recurrences remains unclear.The use of progesterone as an adjuvant therapy for benign metastasising leiomyoma could simply be palliative, with associated psychological benefits, or it could be of therapeutic significance.

View Article: PubMed Central - HTML - PubMed

Affiliation: Clinica di Ginecologia ed Ostetricia, University of Udine, piazzale SM della Misericordia, Udine, Italy. ambrogio.londero@gmail.com

ABSTRACT

Introduction: Benign metastasising leiomyoma refers to a type of lesion characterised by leiomyomatous alterations without any indication of malignancy. It presents as either a singular nodule or multiple nodules of proliferating smooth muscle cells and is generally found in the lungs of women who have undergone a hysterectomy. The purpose of this case report is to contribute to the knowledge of this rare disease by presenting evidence and experience of a patient case. In particular, this report seeks to investigate the therapeutic approaches in order to understand whether a standard of care can be prescribed and whether the use of prophylaxis therapy with progesterone as a follow-up to surgery serves as a reasonable treatment in certain cases diagnosed as benign metastasising leiomyoma.

Case presentation: We present the case of a 52-year-old Caucasian woman who developed a pelvic relapse and a pulmonary localisation of benign metastasising leiomyoma following a hysterectomy for myomatous uterus.

Conclusion: Our literature review revealed a single case of the use of chemoprophylaxis as treatment of a benign metastasising leiomyoma. The role of chemoprophylaxis in preventing future recurrences remains unclear. The use of progesterone as an adjuvant therapy for benign metastasising leiomyoma could simply be palliative, with associated psychological benefits, or it could be of therapeutic significance.

No MeSH data available.


Related in: MedlinePlus