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Locally relapsed and metastatic uterine leiomyoma: a case report.

Londero AP, Perego P, Mangioni C, Lellé RJ, Londero F, Marchesoni D - J Med Case Rep (2008)

Bottom Line: It presents as either a singular nodule or multiple nodules of proliferating smooth muscle cells and is generally found in the lungs of women who have undergone a hysterectomy.The role of chemoprophylaxis in preventing future recurrences remains unclear.The use of progesterone as an adjuvant therapy for benign metastasising leiomyoma could simply be palliative, with associated psychological benefits, or it could be of therapeutic significance.

View Article: PubMed Central - HTML - PubMed

Affiliation: Clinica di Ginecologia ed Ostetricia, University of Udine, piazzale SM della Misericordia, Udine, Italy. ambrogio.londero@gmail.com

ABSTRACT

Introduction: Benign metastasising leiomyoma refers to a type of lesion characterised by leiomyomatous alterations without any indication of malignancy. It presents as either a singular nodule or multiple nodules of proliferating smooth muscle cells and is generally found in the lungs of women who have undergone a hysterectomy. The purpose of this case report is to contribute to the knowledge of this rare disease by presenting evidence and experience of a patient case. In particular, this report seeks to investigate the therapeutic approaches in order to understand whether a standard of care can be prescribed and whether the use of prophylaxis therapy with progesterone as a follow-up to surgery serves as a reasonable treatment in certain cases diagnosed as benign metastasising leiomyoma.

Case presentation: We present the case of a 52-year-old Caucasian woman who developed a pelvic relapse and a pulmonary localisation of benign metastasising leiomyoma following a hysterectomy for myomatous uterus.

Conclusion: Our literature review revealed a single case of the use of chemoprophylaxis as treatment of a benign metastasising leiomyoma. The role of chemoprophylaxis in preventing future recurrences remains unclear. The use of progesterone as an adjuvant therapy for benign metastasising leiomyoma could simply be palliative, with associated psychological benefits, or it could be of therapeutic significance.

No MeSH data available.


Related in: MedlinePlus

(A) Area with oedematous aspect. (B) Normal spindle-shaped smooth muscle cells and area of ischaemic necrosis with haemosiderin deposition. (C) Haemorrhagic area inside the mass (haematoxylin and eosin staining; magnification ×10).
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Figure 2: (A) Area with oedematous aspect. (B) Normal spindle-shaped smooth muscle cells and area of ischaemic necrosis with haemosiderin deposition. (C) Haemorrhagic area inside the mass (haematoxylin and eosin staining; magnification ×10).


Locally relapsed and metastatic uterine leiomyoma: a case report.

Londero AP, Perego P, Mangioni C, Lellé RJ, Londero F, Marchesoni D - J Med Case Rep (2008)

(A) Area with oedematous aspect. (B) Normal spindle-shaped smooth muscle cells and area of ischaemic necrosis with haemosiderin deposition. (C) Haemorrhagic area inside the mass (haematoxylin and eosin staining; magnification ×10).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2563016&req=5

Figure 2: (A) Area with oedematous aspect. (B) Normal spindle-shaped smooth muscle cells and area of ischaemic necrosis with haemosiderin deposition. (C) Haemorrhagic area inside the mass (haematoxylin and eosin staining; magnification ×10).
Bottom Line: It presents as either a singular nodule or multiple nodules of proliferating smooth muscle cells and is generally found in the lungs of women who have undergone a hysterectomy.The role of chemoprophylaxis in preventing future recurrences remains unclear.The use of progesterone as an adjuvant therapy for benign metastasising leiomyoma could simply be palliative, with associated psychological benefits, or it could be of therapeutic significance.

View Article: PubMed Central - HTML - PubMed

Affiliation: Clinica di Ginecologia ed Ostetricia, University of Udine, piazzale SM della Misericordia, Udine, Italy. ambrogio.londero@gmail.com

ABSTRACT

Introduction: Benign metastasising leiomyoma refers to a type of lesion characterised by leiomyomatous alterations without any indication of malignancy. It presents as either a singular nodule or multiple nodules of proliferating smooth muscle cells and is generally found in the lungs of women who have undergone a hysterectomy. The purpose of this case report is to contribute to the knowledge of this rare disease by presenting evidence and experience of a patient case. In particular, this report seeks to investigate the therapeutic approaches in order to understand whether a standard of care can be prescribed and whether the use of prophylaxis therapy with progesterone as a follow-up to surgery serves as a reasonable treatment in certain cases diagnosed as benign metastasising leiomyoma.

Case presentation: We present the case of a 52-year-old Caucasian woman who developed a pelvic relapse and a pulmonary localisation of benign metastasising leiomyoma following a hysterectomy for myomatous uterus.

Conclusion: Our literature review revealed a single case of the use of chemoprophylaxis as treatment of a benign metastasising leiomyoma. The role of chemoprophylaxis in preventing future recurrences remains unclear. The use of progesterone as an adjuvant therapy for benign metastasising leiomyoma could simply be palliative, with associated psychological benefits, or it could be of therapeutic significance.

No MeSH data available.


Related in: MedlinePlus