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Gadd45 in stress signaling.

Liebermann DA, Hoffman B - J Mol Signal (2008)

Bottom Line: Evidence accumulated implies that Gadd45 proteins function as stress sensors is mediated by a complex interplay of physical interactions with other cellular proteins that are implicated in cell cycle regulation and the response of cells to stress.These include PCNA, p21, cdc2/cyclinB1, and the p38 and JNK stress response kinases.What deterministic factors dictate whether Gadd45 and partner proteins function in either cell survival or apoptosis remains to be determined.

View Article: PubMed Central - HTML - PubMed

Affiliation: Fels Institute for Cancer Research & Molecular Biology, & Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA. lieberma@temple.edu.

ABSTRACT
Gadd45 genes have been implicated in stress signaling in response to physiological or environmental stressors, which results in cell cycle arrest, DNA repair, cell survival and senescence, or apoptosis. Evidence accumulated implies that Gadd45 proteins function as stress sensors is mediated by a complex interplay of physical interactions with other cellular proteins that are implicated in cell cycle regulation and the response of cells to stress. These include PCNA, p21, cdc2/cyclinB1, and the p38 and JNK stress response kinases. What deterministic factors dictate whether Gadd45 and partner proteins function in either cell survival or apoptosis remains to be determined. An attractive working model to consider is that the extent of cellular/DNA damage, in a given cell type, dictates the association of different Gadd45 proteins with particular partner proteins, which determines the outcome.

No MeSH data available.


Related in: MedlinePlus

The Gadd45 family of proteins. Alignment of the amino acid sequences of murine MyD118 (Gadd45b), murine Gadd45 (Gadd45a) and murine CR6 (gadd45g). Conserved amino acid regions are boxed.
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Figure 1: The Gadd45 family of proteins. Alignment of the amino acid sequences of murine MyD118 (Gadd45b), murine Gadd45 (Gadd45a) and murine CR6 (gadd45g). Conserved amino acid regions are boxed.

Mentions: Gadd45 genes were cloned in this laboratory [24,25], in the laboratory of Dr. Smith [26] and in the Fornace laboratoy at the NIH [27]. Gadd45, MyD118, and CR6 (currently termed Gadd45a, Gadd45b, & Gadd45g, respectively, and collectively referred to as Gadd45 proteins, gadd45 genes or Gadd45 family) encode for small (18 kd), evolutionarily conserved proteins that are similar to each other (55%–57% overall identity at the amino acid level), are highly acidic (pI = 4.0–4.2), and are localized primarily within the cell nucleus [24-38] (Fig. 1).


Gadd45 in stress signaling.

Liebermann DA, Hoffman B - J Mol Signal (2008)

The Gadd45 family of proteins. Alignment of the amino acid sequences of murine MyD118 (Gadd45b), murine Gadd45 (Gadd45a) and murine CR6 (gadd45g). Conserved amino acid regions are boxed.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2563007&req=5

Figure 1: The Gadd45 family of proteins. Alignment of the amino acid sequences of murine MyD118 (Gadd45b), murine Gadd45 (Gadd45a) and murine CR6 (gadd45g). Conserved amino acid regions are boxed.
Mentions: Gadd45 genes were cloned in this laboratory [24,25], in the laboratory of Dr. Smith [26] and in the Fornace laboratoy at the NIH [27]. Gadd45, MyD118, and CR6 (currently termed Gadd45a, Gadd45b, & Gadd45g, respectively, and collectively referred to as Gadd45 proteins, gadd45 genes or Gadd45 family) encode for small (18 kd), evolutionarily conserved proteins that are similar to each other (55%–57% overall identity at the amino acid level), are highly acidic (pI = 4.0–4.2), and are localized primarily within the cell nucleus [24-38] (Fig. 1).

Bottom Line: Evidence accumulated implies that Gadd45 proteins function as stress sensors is mediated by a complex interplay of physical interactions with other cellular proteins that are implicated in cell cycle regulation and the response of cells to stress.These include PCNA, p21, cdc2/cyclinB1, and the p38 and JNK stress response kinases.What deterministic factors dictate whether Gadd45 and partner proteins function in either cell survival or apoptosis remains to be determined.

View Article: PubMed Central - HTML - PubMed

Affiliation: Fels Institute for Cancer Research & Molecular Biology, & Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA. lieberma@temple.edu.

ABSTRACT
Gadd45 genes have been implicated in stress signaling in response to physiological or environmental stressors, which results in cell cycle arrest, DNA repair, cell survival and senescence, or apoptosis. Evidence accumulated implies that Gadd45 proteins function as stress sensors is mediated by a complex interplay of physical interactions with other cellular proteins that are implicated in cell cycle regulation and the response of cells to stress. These include PCNA, p21, cdc2/cyclinB1, and the p38 and JNK stress response kinases. What deterministic factors dictate whether Gadd45 and partner proteins function in either cell survival or apoptosis remains to be determined. An attractive working model to consider is that the extent of cellular/DNA damage, in a given cell type, dictates the association of different Gadd45 proteins with particular partner proteins, which determines the outcome.

No MeSH data available.


Related in: MedlinePlus