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Ultrastructural pathology of nephropathies with organized deposits: a case series.

Fabbian F, Stabellini N, Galdi A, Sartori S, Aleotti A, Catizone L - Cases J (2008)

Bottom Line: Proteinuria was detected in all patients while monoclonal component was present only in the serum of one subject.Diagnoses that were made are the following: membranoproliferative glomerulonephritis with finger print, immunotactoid glomerulopathy, membranoproliferative glomerulonephritis with arched deposits, primary amyloidosis and light chain deposition disease.In systemic disorders ultrastructural pathology could be particularly valuable for correct deposits classification, precise localization and pattern of deposition of Igs.

View Article: PubMed Central - HTML - PubMed

Affiliation: Renal Unit, St, Anna Hospital, Corso Giovecca 203, 44100 Ferrara, Italy. hrfabbia@tin.it.

ABSTRACT
Renal organized or structured deposits are much less frequent than those with usual type immunocomplex deposits and are encountered in a wide variety of primary and systemic disorders. It has been suggested that immunoglobulins (Igs) are responsible for organized deposits. We report 5 cases who have been diagnosed and treated in our hospital. Patients were aged 52 to 72 years, three of them were males and had variable degree of renal function, from normal serum creatinine to uraemia. Proteinuria was detected in all patients while monoclonal component was present only in the serum of one subject. Ultrastructural analysis of renal specimens revealed organized deposits. Diagnoses that were made are the following: membranoproliferative glomerulonephritis with finger print, immunotactoid glomerulopathy, membranoproliferative glomerulonephritis with arched deposits, primary amyloidosis and light chain deposition disease. In systemic disorders ultrastructural pathology could be particularly valuable for correct deposits classification, precise localization and pattern of deposition of Igs.

No MeSH data available.


Related in: MedlinePlus

Fingerprint-like intramembranous deposit (magnification ×60000).
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Figure 1: Fingerprint-like intramembranous deposit (magnification ×60000).

Mentions: A 64-year-old Caucasian man was referred to our unit because of mild hypertension and peripheral oedema. Renal function was normal but he had proteinuria (3.5 g/24 h). His serum albumin was 25 g/L associated with high immunoglobulins level. Serum C3 and C4 were normal, he had abnormal liver function, markers for hepatitis C virus (HCV) infection were negative whilst HBsAg was positive. Cryoglobulins were not detected. An abdominal ultrasound showed increased in liver and spleen volume. Liver and renal biopsies were performed and revealed hepatitis and membrano-proliferative glomerulonephritis associated with "finger-print" deposits (Figure 1).


Ultrastructural pathology of nephropathies with organized deposits: a case series.

Fabbian F, Stabellini N, Galdi A, Sartori S, Aleotti A, Catizone L - Cases J (2008)

Fingerprint-like intramembranous deposit (magnification ×60000).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2562358&req=5

Figure 1: Fingerprint-like intramembranous deposit (magnification ×60000).
Mentions: A 64-year-old Caucasian man was referred to our unit because of mild hypertension and peripheral oedema. Renal function was normal but he had proteinuria (3.5 g/24 h). His serum albumin was 25 g/L associated with high immunoglobulins level. Serum C3 and C4 were normal, he had abnormal liver function, markers for hepatitis C virus (HCV) infection were negative whilst HBsAg was positive. Cryoglobulins were not detected. An abdominal ultrasound showed increased in liver and spleen volume. Liver and renal biopsies were performed and revealed hepatitis and membrano-proliferative glomerulonephritis associated with "finger-print" deposits (Figure 1).

Bottom Line: Proteinuria was detected in all patients while monoclonal component was present only in the serum of one subject.Diagnoses that were made are the following: membranoproliferative glomerulonephritis with finger print, immunotactoid glomerulopathy, membranoproliferative glomerulonephritis with arched deposits, primary amyloidosis and light chain deposition disease.In systemic disorders ultrastructural pathology could be particularly valuable for correct deposits classification, precise localization and pattern of deposition of Igs.

View Article: PubMed Central - HTML - PubMed

Affiliation: Renal Unit, St, Anna Hospital, Corso Giovecca 203, 44100 Ferrara, Italy. hrfabbia@tin.it.

ABSTRACT
Renal organized or structured deposits are much less frequent than those with usual type immunocomplex deposits and are encountered in a wide variety of primary and systemic disorders. It has been suggested that immunoglobulins (Igs) are responsible for organized deposits. We report 5 cases who have been diagnosed and treated in our hospital. Patients were aged 52 to 72 years, three of them were males and had variable degree of renal function, from normal serum creatinine to uraemia. Proteinuria was detected in all patients while monoclonal component was present only in the serum of one subject. Ultrastructural analysis of renal specimens revealed organized deposits. Diagnoses that were made are the following: membranoproliferative glomerulonephritis with finger print, immunotactoid glomerulopathy, membranoproliferative glomerulonephritis with arched deposits, primary amyloidosis and light chain deposition disease. In systemic disorders ultrastructural pathology could be particularly valuable for correct deposits classification, precise localization and pattern of deposition of Igs.

No MeSH data available.


Related in: MedlinePlus