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An association study of ADSS gene polymorphisms with schizophrenia.

Zhang F, Sham PC, Fan H, Xu Y, Huang X, So H, Song Y, Liu P - Behav Brain Funct (2008)

Bottom Line: However, it remains unclear whether the reduction of ADSS RNA is due to the polymorphisms of the gene or not.There was no significant difference of genotypic, allelic, or haplotypic distributions of the 6 SNPs between the two groups.Our data did not support ADSS gene as a susceptibility gene for SZ in Chinese Han population.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Neurological disorders, Tsinghua University; Department of Psychiatry, Yuquan Hospital, Tsinghua University, Bejing, 100049, PR China. liupozi@tsinghua.edu.cn.

ABSTRACT

Background: Adenylosuccinate synthase (ADSS) catalyzes the first committed step of AMP synthesis. It was suggested that the blood-derived RNA of ADSS was down-regulated in schizophrenia (SZ) and one of the eight putative biomarker genes to discriminate SZ from normal controls. However, it remains unclear whether the reduction of ADSS RNA is due to the polymorphisms of the gene or not.

Methods: We attempted to examine the association of ADSS gene with schizophrenia in a Chinese population of 480 schizophrenics and 502 normal controls. Genotyping was performed by the Sequenom platform.

Results: The 6 marker SNPs (rs3102460, rs3127459, rs3127460, rs3127465, rs3006001, and rs3003211) were genotyped. The frequencies of alleles, genotypes, and haplotypes were tested between cases and controls. There was no significant difference of genotypic, allelic, or haplotypic distributions of the 6 SNPs between the two groups.

Conclusion: Our data did not support ADSS gene as a susceptibility gene for SZ in Chinese Han population. Large sample size study is needed to validate or replicate our association study, especially from other ethnic populations.

No MeSH data available.


Related in: MedlinePlus

Graphical representation of LD patterns of the six SNPs in the total sample. The graphic represents the pairwise calculation of r2 for each pair of SNPs at each gene. Squares represent r2 values. Values within boxes are the measures of r2 between pairs of markers in a scale from 0 to 100. If there is no value, r2 = 1.
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Figure 1: Graphical representation of LD patterns of the six SNPs in the total sample. The graphic represents the pairwise calculation of r2 for each pair of SNPs at each gene. Squares represent r2 values. Values within boxes are the measures of r2 between pairs of markers in a scale from 0 to 100. If there is no value, r2 = 1.

Mentions: The patterns of Pair-wise LD between neighbouring SNPs were shown in figure 1. Fairly tight linkage disequilibrium was observed in any pair of the SNPs and the six markers were in strong LD.


An association study of ADSS gene polymorphisms with schizophrenia.

Zhang F, Sham PC, Fan H, Xu Y, Huang X, So H, Song Y, Liu P - Behav Brain Funct (2008)

Graphical representation of LD patterns of the six SNPs in the total sample. The graphic represents the pairwise calculation of r2 for each pair of SNPs at each gene. Squares represent r2 values. Values within boxes are the measures of r2 between pairs of markers in a scale from 0 to 100. If there is no value, r2 = 1.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2553416&req=5

Figure 1: Graphical representation of LD patterns of the six SNPs in the total sample. The graphic represents the pairwise calculation of r2 for each pair of SNPs at each gene. Squares represent r2 values. Values within boxes are the measures of r2 between pairs of markers in a scale from 0 to 100. If there is no value, r2 = 1.
Mentions: The patterns of Pair-wise LD between neighbouring SNPs were shown in figure 1. Fairly tight linkage disequilibrium was observed in any pair of the SNPs and the six markers were in strong LD.

Bottom Line: However, it remains unclear whether the reduction of ADSS RNA is due to the polymorphisms of the gene or not.There was no significant difference of genotypic, allelic, or haplotypic distributions of the 6 SNPs between the two groups.Our data did not support ADSS gene as a susceptibility gene for SZ in Chinese Han population.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Neurological disorders, Tsinghua University; Department of Psychiatry, Yuquan Hospital, Tsinghua University, Bejing, 100049, PR China. liupozi@tsinghua.edu.cn.

ABSTRACT

Background: Adenylosuccinate synthase (ADSS) catalyzes the first committed step of AMP synthesis. It was suggested that the blood-derived RNA of ADSS was down-regulated in schizophrenia (SZ) and one of the eight putative biomarker genes to discriminate SZ from normal controls. However, it remains unclear whether the reduction of ADSS RNA is due to the polymorphisms of the gene or not.

Methods: We attempted to examine the association of ADSS gene with schizophrenia in a Chinese population of 480 schizophrenics and 502 normal controls. Genotyping was performed by the Sequenom platform.

Results: The 6 marker SNPs (rs3102460, rs3127459, rs3127460, rs3127465, rs3006001, and rs3003211) were genotyped. The frequencies of alleles, genotypes, and haplotypes were tested between cases and controls. There was no significant difference of genotypic, allelic, or haplotypic distributions of the 6 SNPs between the two groups.

Conclusion: Our data did not support ADSS gene as a susceptibility gene for SZ in Chinese Han population. Large sample size study is needed to validate or replicate our association study, especially from other ethnic populations.

No MeSH data available.


Related in: MedlinePlus