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Resveratrol in prevention and treatment of common clinical conditions of aging.

Markus MA, Morris BJ - Clin Interv Aging (2008)

Bottom Line: We present the latest molecular findings that account for the beneficial actions of resveratrol.The intracellular pathways activated are crucial for anti-oxidant defence, regulation of the cell cycle, mitochondrial energy production, vascular tone, oncogene suppression, and many other phenomena which if unchecked lead to morbidity and mortality from onset and progression of these various diseases.While a healthy diet and lifestyle is strongly recommended in prevention of such conditions, the future bodes well for the use of resveratrol and analogues of higher potency than the natural form for treatment of diseases that afflict humans, particularly as they age.

View Article: PubMed Central - PubMed

Affiliation: School of Medical Sciences, Bosch Institute, The University of Sydney, Sydney, NSW, Australia. andream@medsci.usyd.edu.au

ABSTRACT
Resveratrol is a potent member of the class of natural, plant-derived chemicals known as polyphenols. These help explain in part why a diet high in fruit and vegetables confers health benefits and are associated with reduced risk of common complex conditions such as cardiovascular disease, cancer, diabetes, and Alzheimer's disease. We present the latest molecular findings that account for the beneficial actions of resveratrol. The intracellular pathways activated are crucial for anti-oxidant defence, regulation of the cell cycle, mitochondrial energy production, vascular tone, oncogene suppression, and many other phenomena which if unchecked lead to morbidity and mortality from onset and progression of these various diseases. While a healthy diet and lifestyle is strongly recommended in prevention of such conditions, the future bodes well for the use of resveratrol and analogues of higher potency than the natural form for treatment of diseases that afflict humans, particularly as they age.

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Related in: MedlinePlus

Chemical structure of resveratrol.
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fig1: Chemical structure of resveratrol.

Mentions: Resveratrol (trans-3,5,4’-trihydroxystilbene or 5-[(E)-2-(4-hydroxyphenyl)-ethenyl]benzene-1,3-diol; C14H12O3) (Figure 1), is a polyphenolic flavonoid found in the seeds and skins of grapes, red wine, mulberries, peanuts, and rhubarb. Polyphenols exert a diversity of health benefits by activating intracellular pathways, many of which are the same as those activated by calorie restriction, an intervention long known to enhance health and prolong lifespan (Wood et al 2004). An early target of resveratrol is the sirtuin class of nicotinamide adenine dinucleotide (NAD)-dependent deacetylases. Seven sirtuins have been identified in mammals, of which SIRT-1 is believed to mediate the beneficial effects on health and longevity of both calorie restriction and resveratrol (Guarente and Picard 2005). A number of intracellular pathways are activated by SIRT-1 (Figure 2). The extent to which the sirtuin-activating actions of resveratrol are direct or indirect is still not resolved completely (Denu 2005). The pathways regulated by sirtuins include gluconeogenesis and glycolysis in the liver, fat metabolism, and cell survival. Depending on cell type and circumstances, sirtuins activate or suppress members of the forkhead box O (FOXO) group of transcription factors. FOXOs then activate or suppress specific genes, leading to a decrease in apoptosis, an increase in antioxidant activities, DNA protection, anti-inflammatory effects, and modulation of various other mechanisms so as to promote the health of the cell, and thus the organism (reviewed by Morris 2005, 2008). It may be that sirtuins benefit survival by ramping up stress resistance pathways in cells in times of adversity (Guarente and Picard 2005). Several recent reports presented evidence that SIRT-1 interacts directly and deacetylates the metabolic regulator and transcriptional coactivator, peroxisome proliferator-activated receptor-γ co-activator 1α (PGC-1α). By doing so it improves mitochondrial function, induces genes for mitochondrial and fatty acid oxidation and increases mitochondrial membrane potential (Lagouge et al 2006; Gerhart-Hines et al 2007; Anderson et al 2008).


Resveratrol in prevention and treatment of common clinical conditions of aging.

Markus MA, Morris BJ - Clin Interv Aging (2008)

Chemical structure of resveratrol.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2546476&req=5

fig1: Chemical structure of resveratrol.
Mentions: Resveratrol (trans-3,5,4’-trihydroxystilbene or 5-[(E)-2-(4-hydroxyphenyl)-ethenyl]benzene-1,3-diol; C14H12O3) (Figure 1), is a polyphenolic flavonoid found in the seeds and skins of grapes, red wine, mulberries, peanuts, and rhubarb. Polyphenols exert a diversity of health benefits by activating intracellular pathways, many of which are the same as those activated by calorie restriction, an intervention long known to enhance health and prolong lifespan (Wood et al 2004). An early target of resveratrol is the sirtuin class of nicotinamide adenine dinucleotide (NAD)-dependent deacetylases. Seven sirtuins have been identified in mammals, of which SIRT-1 is believed to mediate the beneficial effects on health and longevity of both calorie restriction and resveratrol (Guarente and Picard 2005). A number of intracellular pathways are activated by SIRT-1 (Figure 2). The extent to which the sirtuin-activating actions of resveratrol are direct or indirect is still not resolved completely (Denu 2005). The pathways regulated by sirtuins include gluconeogenesis and glycolysis in the liver, fat metabolism, and cell survival. Depending on cell type and circumstances, sirtuins activate or suppress members of the forkhead box O (FOXO) group of transcription factors. FOXOs then activate or suppress specific genes, leading to a decrease in apoptosis, an increase in antioxidant activities, DNA protection, anti-inflammatory effects, and modulation of various other mechanisms so as to promote the health of the cell, and thus the organism (reviewed by Morris 2005, 2008). It may be that sirtuins benefit survival by ramping up stress resistance pathways in cells in times of adversity (Guarente and Picard 2005). Several recent reports presented evidence that SIRT-1 interacts directly and deacetylates the metabolic regulator and transcriptional coactivator, peroxisome proliferator-activated receptor-γ co-activator 1α (PGC-1α). By doing so it improves mitochondrial function, induces genes for mitochondrial and fatty acid oxidation and increases mitochondrial membrane potential (Lagouge et al 2006; Gerhart-Hines et al 2007; Anderson et al 2008).

Bottom Line: We present the latest molecular findings that account for the beneficial actions of resveratrol.The intracellular pathways activated are crucial for anti-oxidant defence, regulation of the cell cycle, mitochondrial energy production, vascular tone, oncogene suppression, and many other phenomena which if unchecked lead to morbidity and mortality from onset and progression of these various diseases.While a healthy diet and lifestyle is strongly recommended in prevention of such conditions, the future bodes well for the use of resveratrol and analogues of higher potency than the natural form for treatment of diseases that afflict humans, particularly as they age.

View Article: PubMed Central - PubMed

Affiliation: School of Medical Sciences, Bosch Institute, The University of Sydney, Sydney, NSW, Australia. andream@medsci.usyd.edu.au

ABSTRACT
Resveratrol is a potent member of the class of natural, plant-derived chemicals known as polyphenols. These help explain in part why a diet high in fruit and vegetables confers health benefits and are associated with reduced risk of common complex conditions such as cardiovascular disease, cancer, diabetes, and Alzheimer's disease. We present the latest molecular findings that account for the beneficial actions of resveratrol. The intracellular pathways activated are crucial for anti-oxidant defence, regulation of the cell cycle, mitochondrial energy production, vascular tone, oncogene suppression, and many other phenomena which if unchecked lead to morbidity and mortality from onset and progression of these various diseases. While a healthy diet and lifestyle is strongly recommended in prevention of such conditions, the future bodes well for the use of resveratrol and analogues of higher potency than the natural form for treatment of diseases that afflict humans, particularly as they age.

Show MeSH
Related in: MedlinePlus