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s-ICAM-1 and s-VCAM-1 in healthy men are strongly associated with traits of the metabolic syndrome, becoming evident in the postprandial response to a lipid-rich meal.

Rubin D, Claas S, Pfeuffer M, Nothnagel M, Foelsch UR, Schrezenmeir J - Lipids Health Dis (2008)

Bottom Line: Fasting sICAM-1 and sVCAM-1 levels were significantly higher in HR as compared to NR (p = 0.046, p = 0.03).There was a strong positive and independent correlation between sICAM-1 and postprandial insulin maxima (r = 0.70, p < 0.001). sVCAM-1 showed significant correlation with postprandial triglycerides (AUC) (r = 0.37, p = 0.047).We found no correlation between sCAMs and fasting insulin or triglyceride concentrations.

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Affiliation: Max-Rubner-Institut, Federal Research Center of Nutrition and Food, Herrmann-Weigmann-Str.1, 24103 Kiel, Germany. drubin@1med.uni-kiel.de

ABSTRACT

Background: The importance of the postprandial state for the early stages of atherogenesis is increasingly acknowledged. We conducted assessment of association between postprandial triglycerides, insulin and glucose after ingestion of a standardized lipid-rich test meal, and soluble cellular adhesion molecules (sCAM) in young healthy subjects.

Methods: Metabolic parameters and sICAM-1, sVCAM-1 and E-selectin were measured before and hourly until 6 hours after ingestion of a lipid-rich meal in 30 healthy young men with fasting triglycerides <150 mg/dl and normal fasting glucose levels. Subjects were classified as either normal responders (NR) (postprandial triglyceride maxima < 260 mg/dl) or high responders (HR) (postprandial triglyceride maxima > 260 mg/dl). Levels of CAM were compared in HR and NR, and correlation with postprandial triglyceride, insulin and glucose response was assessed.

Results: Fasting sICAM-1 and sVCAM-1 levels were significantly higher in HR as compared to NR (p = 0.046, p = 0.03). For sE-selectin there was such a trend (p = 0.05). There was a strong positive and independent correlation between sICAM-1 and postprandial insulin maxima (r = 0.70, p < 0.001). sVCAM-1 showed significant correlation with postprandial triglycerides (AUC) (r = 0.37, p = 0.047). We found no correlation between sCAMs and fasting insulin or triglyceride concentrations.

Conclusion: This independent association of postprandial triglycerides with sICAM-1 may indicate a particular impact of postprandial lipid metabolism on endothelial reaction.

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Postprandial concentrations of sVCAM-1. Plasma sVCAM-1 concentrations following ingestion of an oral metabolic tolerance test in 15 normal (●, NR) and 15 high (△, HR) triglyceride responders (mean ± SEM).
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Figure 5: Postprandial concentrations of sVCAM-1. Plasma sVCAM-1 concentrations following ingestion of an oral metabolic tolerance test in 15 normal (●, NR) and 15 high (△, HR) triglyceride responders (mean ± SEM).

Mentions: Soluble adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) did not increase in the postprandial state (Figure 4, 5, 6). Neither the levels at single postprandial time points nor the means over observation time differed from fasting concentrations for sICAM-1, sVCAM-1 and sE-selectin. Therefore, the fasting values were used to analyze differences between NR and HR. sICAM-1 levels were significantly different between NR (210.2 ± 5.94 ng/ml) and HR (304.3 ± 5.69 ng/ml, p = 0.046). Plasma levels of sVCAM-1 were also significantly higher in HR (p = 0.047). Soluble E-selectin levels were not significantly different but tended to be higher in HR (18.4 ± 9.6 vs. 13.2 ± 7.4, p = 0.05).


s-ICAM-1 and s-VCAM-1 in healthy men are strongly associated with traits of the metabolic syndrome, becoming evident in the postprandial response to a lipid-rich meal.

Rubin D, Claas S, Pfeuffer M, Nothnagel M, Foelsch UR, Schrezenmeir J - Lipids Health Dis (2008)

Postprandial concentrations of sVCAM-1. Plasma sVCAM-1 concentrations following ingestion of an oral metabolic tolerance test in 15 normal (●, NR) and 15 high (△, HR) triglyceride responders (mean ± SEM).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2543007&req=5

Figure 5: Postprandial concentrations of sVCAM-1. Plasma sVCAM-1 concentrations following ingestion of an oral metabolic tolerance test in 15 normal (●, NR) and 15 high (△, HR) triglyceride responders (mean ± SEM).
Mentions: Soluble adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) did not increase in the postprandial state (Figure 4, 5, 6). Neither the levels at single postprandial time points nor the means over observation time differed from fasting concentrations for sICAM-1, sVCAM-1 and sE-selectin. Therefore, the fasting values were used to analyze differences between NR and HR. sICAM-1 levels were significantly different between NR (210.2 ± 5.94 ng/ml) and HR (304.3 ± 5.69 ng/ml, p = 0.046). Plasma levels of sVCAM-1 were also significantly higher in HR (p = 0.047). Soluble E-selectin levels were not significantly different but tended to be higher in HR (18.4 ± 9.6 vs. 13.2 ± 7.4, p = 0.05).

Bottom Line: Fasting sICAM-1 and sVCAM-1 levels were significantly higher in HR as compared to NR (p = 0.046, p = 0.03).There was a strong positive and independent correlation between sICAM-1 and postprandial insulin maxima (r = 0.70, p < 0.001). sVCAM-1 showed significant correlation with postprandial triglycerides (AUC) (r = 0.37, p = 0.047).We found no correlation between sCAMs and fasting insulin or triglyceride concentrations.

View Article: PubMed Central - HTML - PubMed

Affiliation: Max-Rubner-Institut, Federal Research Center of Nutrition and Food, Herrmann-Weigmann-Str.1, 24103 Kiel, Germany. drubin@1med.uni-kiel.de

ABSTRACT

Background: The importance of the postprandial state for the early stages of atherogenesis is increasingly acknowledged. We conducted assessment of association between postprandial triglycerides, insulin and glucose after ingestion of a standardized lipid-rich test meal, and soluble cellular adhesion molecules (sCAM) in young healthy subjects.

Methods: Metabolic parameters and sICAM-1, sVCAM-1 and E-selectin were measured before and hourly until 6 hours after ingestion of a lipid-rich meal in 30 healthy young men with fasting triglycerides <150 mg/dl and normal fasting glucose levels. Subjects were classified as either normal responders (NR) (postprandial triglyceride maxima < 260 mg/dl) or high responders (HR) (postprandial triglyceride maxima > 260 mg/dl). Levels of CAM were compared in HR and NR, and correlation with postprandial triglyceride, insulin and glucose response was assessed.

Results: Fasting sICAM-1 and sVCAM-1 levels were significantly higher in HR as compared to NR (p = 0.046, p = 0.03). For sE-selectin there was such a trend (p = 0.05). There was a strong positive and independent correlation between sICAM-1 and postprandial insulin maxima (r = 0.70, p < 0.001). sVCAM-1 showed significant correlation with postprandial triglycerides (AUC) (r = 0.37, p = 0.047). We found no correlation between sCAMs and fasting insulin or triglyceride concentrations.

Conclusion: This independent association of postprandial triglycerides with sICAM-1 may indicate a particular impact of postprandial lipid metabolism on endothelial reaction.

Show MeSH
Related in: MedlinePlus