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Endothelial function and urine albumin levels among asymptomatic Mexican-Americans and non-Hispanic whites.

Gardin JM, Allebban Z, Wong ND, Sklar SK, Bess RL, Spence MA, Pershadsingh HA - Cardiovasc Ultrasound (2008)

Bottom Line: Mexican-Americans (MA) exhibit increases in various cardiovascular disease (CVD) risk factors compared to non-Hispanic Whites (NHW), yet are reported to have lower CVD mortality rates.To our knowledge, this is the first study to analyze, in asymptomatic adults, the relation of MA and NHW ethnicity to FMD and urine albumin levels.The findings confirm ethnic differences in these important subclinical CVD measures.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Cardiology, Department of Medicine, St, John Hospital & Medical Center, Detroit, MI 48236, USA. JGardin@humed.com

ABSTRACT

Background: Mexican-Americans (MA) exhibit increases in various cardiovascular disease (CVD) risk factors compared to non-Hispanic Whites (NHW), yet are reported to have lower CVD mortality rates. Our aim was to help explain this apparent paradox by evaluating endothelial function and urine albumin levels in MA and NHW.

Methods: One hundred-five MA and 100 NHW adults were studied by brachial artery flow-mediated dilatation (FMD), blood and urine tests. Participants were studied by ultrasound-determined brachial artery flow-mediated dilatation (FMD), blood and urine tests, at a single visit.

Results: Despite higher BMI and triglycerides in MA, MA demonstrated higher FMD than did NHW (9.1 +/- 7.3% vs. 7.1 +/- 6.3%, p < 0.04). Among MA, urinary albumin was consistently lower in participants with FMD >or= 7% FMD versus < 7% FMD (p < 0.006). In multivariate analyses in MA men, urinary albumin was inversely related to FMD (r = -0.26, p < 0.05), as were BMI and systolic blood pressure. In MA women, urinary albumin:creatinine ratio was an independent inverse predictor of FMD (p < 0.05 ).

Conclusion: To our knowledge, this is the first study to analyze, in asymptomatic adults, the relation of MA and NHW ethnicity to FMD and urine albumin levels. The findings confirm ethnic differences in these important subclinical CVD measures.

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Related in: MedlinePlus

Flow-mediated dilatation and urine albumin levels in Mexican-American and non-Hispanic white men (top panel) and women (bottom panel).
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Figure 1: Flow-mediated dilatation and urine albumin levels in Mexican-American and non-Hispanic white men (top panel) and women (bottom panel).

Mentions: The relationship between FMD and urinary albumin is displayed in Figure 1 for MA versus NHW men and for MA versus NHW women. Overall, FMD in MA and NHW men and women decreased as urinary albumin levels increased. Among women with urinary albumin levels of 1.1–1.5 mg/dl, FMD was significantly higher in MA than in NHW women (p < 0.05) (Figure 1). In MA men with urinary albumin levels of 0–0.5 mg/dl, FMD trended higher than in NHW men with the same albumin levels (p < 0.08). Meanwhile, in MA men with urinary albumin levels of 0.0–0.5 mg/dl, FMD was nearly significantly higher than in MA men with urinary levels of 0.6–1.0 mg/dl (p < 0.06). In NHW men with urinary albumin levels of 0–0.5 mg/dl, FMD trended higher than in NHW men with urinary albumin levels of 1.1–1.5 mg/dl (p = 0.054).


Endothelial function and urine albumin levels among asymptomatic Mexican-Americans and non-Hispanic whites.

Gardin JM, Allebban Z, Wong ND, Sklar SK, Bess RL, Spence MA, Pershadsingh HA - Cardiovasc Ultrasound (2008)

Flow-mediated dilatation and urine albumin levels in Mexican-American and non-Hispanic white men (top panel) and women (bottom panel).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2542998&req=5

Figure 1: Flow-mediated dilatation and urine albumin levels in Mexican-American and non-Hispanic white men (top panel) and women (bottom panel).
Mentions: The relationship between FMD and urinary albumin is displayed in Figure 1 for MA versus NHW men and for MA versus NHW women. Overall, FMD in MA and NHW men and women decreased as urinary albumin levels increased. Among women with urinary albumin levels of 1.1–1.5 mg/dl, FMD was significantly higher in MA than in NHW women (p < 0.05) (Figure 1). In MA men with urinary albumin levels of 0–0.5 mg/dl, FMD trended higher than in NHW men with the same albumin levels (p < 0.08). Meanwhile, in MA men with urinary albumin levels of 0.0–0.5 mg/dl, FMD was nearly significantly higher than in MA men with urinary levels of 0.6–1.0 mg/dl (p < 0.06). In NHW men with urinary albumin levels of 0–0.5 mg/dl, FMD trended higher than in NHW men with urinary albumin levels of 1.1–1.5 mg/dl (p = 0.054).

Bottom Line: Mexican-Americans (MA) exhibit increases in various cardiovascular disease (CVD) risk factors compared to non-Hispanic Whites (NHW), yet are reported to have lower CVD mortality rates.To our knowledge, this is the first study to analyze, in asymptomatic adults, the relation of MA and NHW ethnicity to FMD and urine albumin levels.The findings confirm ethnic differences in these important subclinical CVD measures.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Cardiology, Department of Medicine, St, John Hospital & Medical Center, Detroit, MI 48236, USA. JGardin@humed.com

ABSTRACT

Background: Mexican-Americans (MA) exhibit increases in various cardiovascular disease (CVD) risk factors compared to non-Hispanic Whites (NHW), yet are reported to have lower CVD mortality rates. Our aim was to help explain this apparent paradox by evaluating endothelial function and urine albumin levels in MA and NHW.

Methods: One hundred-five MA and 100 NHW adults were studied by brachial artery flow-mediated dilatation (FMD), blood and urine tests. Participants were studied by ultrasound-determined brachial artery flow-mediated dilatation (FMD), blood and urine tests, at a single visit.

Results: Despite higher BMI and triglycerides in MA, MA demonstrated higher FMD than did NHW (9.1 +/- 7.3% vs. 7.1 +/- 6.3%, p < 0.04). Among MA, urinary albumin was consistently lower in participants with FMD >or= 7% FMD versus < 7% FMD (p < 0.006). In multivariate analyses in MA men, urinary albumin was inversely related to FMD (r = -0.26, p < 0.05), as were BMI and systolic blood pressure. In MA women, urinary albumin:creatinine ratio was an independent inverse predictor of FMD (p < 0.05 ).

Conclusion: To our knowledge, this is the first study to analyze, in asymptomatic adults, the relation of MA and NHW ethnicity to FMD and urine albumin levels. The findings confirm ethnic differences in these important subclinical CVD measures.

Show MeSH
Related in: MedlinePlus