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Fasting differentially modulates the immunological system: its mechanism and sex difference.

Hiramoto K, Homma T, Jikumaru M, Miyashita H, Sato EF, Inoue M - J Clin Biochem Nutr (2008)

Bottom Line: These changes occurred more apparently in males than in females.Under identical conditions, the plasma levels of testosterone decreased markedly with concomitant occurrence of apoptosis in the testis, while the plasma levels of estradiol decreased calmly, and no appreciable apoptosis occurred in the ovary.These results indicate that testosterone enhances the stress-induced modulation of the immune system by some mechanism that was antagonized by estradiol.

View Article: PubMed Central - PubMed

Affiliation: Department of Basic Research, Kitasato Institute, Tokyo 108-8642, Japan.

ABSTRACT
The immunological properties and hormonal metabolism in rodents are affected by physical and psychological stress more strongly in males than in females. To elucidate the mechanism and physiological significance of the sex difference in the susceptibility of animal to stresses, changes in the immunological system in plasma and intestine and hormonal status in plasma were compared among 8-week-old male and female ICR mice before and after fasting. During the fasting of animals, the expression of immunoglobulin A in intestinal mucosa, and cortisol, interleukin-10 and interferon-gamma in plasma increased. These changes occurred more apparently in males than in females. Under identical conditions, the plasma levels of testosterone decreased markedly with concomitant occurrence of apoptosis in the testis, while the plasma levels of estradiol decreased calmly, and no appreciable apoptosis occurred in the ovary. These results indicate that testosterone enhances the stress-induced modulation of the immune system by some mechanism that was antagonized by estradiol.

No MeSH data available.


Related in: MedlinePlus

Histological examination of the expression of IgA in the colon. At the indicated times of fasting, colon specimens were frozen, cut into thin sections, treated with anti-IgA antibody and then stained with FITC-conjugated second antibody. The expression of IgA was determined in the male mice (A) or female mice (B). Data show one typical result out of 3 representative experiments. Scale bar = 50 µm.
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Figure 5: Histological examination of the expression of IgA in the colon. At the indicated times of fasting, colon specimens were frozen, cut into thin sections, treated with anti-IgA antibody and then stained with FITC-conjugated second antibody. The expression of IgA was determined in the male mice (A) or female mice (B). Data show one typical result out of 3 representative experiments. Scale bar = 50 µm.

Mentions: The neuro-immune network system is activated by a sequence of stress reactions to stimulate Th2-dependent immune system. To classify the mechanism for the sex different reactions, we analyzed plasma levels of IL-10 (Fig. 3) and IgA in intestinal mucosa (Fig. 5) as markers for Th2-type immune reaction during the fasting.


Fasting differentially modulates the immunological system: its mechanism and sex difference.

Hiramoto K, Homma T, Jikumaru M, Miyashita H, Sato EF, Inoue M - J Clin Biochem Nutr (2008)

Histological examination of the expression of IgA in the colon. At the indicated times of fasting, colon specimens were frozen, cut into thin sections, treated with anti-IgA antibody and then stained with FITC-conjugated second antibody. The expression of IgA was determined in the male mice (A) or female mice (B). Data show one typical result out of 3 representative experiments. Scale bar = 50 µm.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC2533722&req=5

Figure 5: Histological examination of the expression of IgA in the colon. At the indicated times of fasting, colon specimens were frozen, cut into thin sections, treated with anti-IgA antibody and then stained with FITC-conjugated second antibody. The expression of IgA was determined in the male mice (A) or female mice (B). Data show one typical result out of 3 representative experiments. Scale bar = 50 µm.
Mentions: The neuro-immune network system is activated by a sequence of stress reactions to stimulate Th2-dependent immune system. To classify the mechanism for the sex different reactions, we analyzed plasma levels of IL-10 (Fig. 3) and IgA in intestinal mucosa (Fig. 5) as markers for Th2-type immune reaction during the fasting.

Bottom Line: These changes occurred more apparently in males than in females.Under identical conditions, the plasma levels of testosterone decreased markedly with concomitant occurrence of apoptosis in the testis, while the plasma levels of estradiol decreased calmly, and no appreciable apoptosis occurred in the ovary.These results indicate that testosterone enhances the stress-induced modulation of the immune system by some mechanism that was antagonized by estradiol.

View Article: PubMed Central - PubMed

Affiliation: Department of Basic Research, Kitasato Institute, Tokyo 108-8642, Japan.

ABSTRACT
The immunological properties and hormonal metabolism in rodents are affected by physical and psychological stress more strongly in males than in females. To elucidate the mechanism and physiological significance of the sex difference in the susceptibility of animal to stresses, changes in the immunological system in plasma and intestine and hormonal status in plasma were compared among 8-week-old male and female ICR mice before and after fasting. During the fasting of animals, the expression of immunoglobulin A in intestinal mucosa, and cortisol, interleukin-10 and interferon-gamma in plasma increased. These changes occurred more apparently in males than in females. Under identical conditions, the plasma levels of testosterone decreased markedly with concomitant occurrence of apoptosis in the testis, while the plasma levels of estradiol decreased calmly, and no appreciable apoptosis occurred in the ovary. These results indicate that testosterone enhances the stress-induced modulation of the immune system by some mechanism that was antagonized by estradiol.

No MeSH data available.


Related in: MedlinePlus