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The HTLV-1 Tax interactome.

Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L - Retrovirology (2008)

Bottom Line: Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation.To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins.In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.

View Article: PubMed Central - HTML - PubMed

Affiliation: University Academia Wallonie-Europe, Molecular and Cellular Biology at FUSAGx, Gembloux, Belgium. boxus.m@fsagx.ac.be

ABSTRACT
The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.

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Overview of the Tax1 interactome.
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Figure 5: Overview of the Tax1 interactome.

Mentions: The most intriguing point relating to the Tax1 interactome is the very high number of cellular proteins to which this viral oncogene is able to interact. Today, about 100 Tax1-binding proteins are identified (Table 1) and this number is permanently growing (see for regular updates). Is it possible that a single protein modulates such a wide variety of functions? Are these interactions all relevant for the viral life cycle or pathogenesis? As schematized on Figure 5, the vast majority of these interactions contributes to viral or cellular gene expression and promotes infected cell proliferation or survival, required for maintaining viral load in vivo [231,305]. On the other hand, checkpoint abrogation allows proliferation of cells with DNA lesions and progressive accumulation of chromosomal abnormalities as frequently observed in ATL [220]. Even if one might entertain doubts about the biological relevance of some Tax1 partners, the Tax1 interactome as a whole likely contributes to the viral life cycle as well as to development of pathogenesis.


The HTLV-1 Tax interactome.

Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L - Retrovirology (2008)

Overview of the Tax1 interactome.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2533353&req=5

Figure 5: Overview of the Tax1 interactome.
Mentions: The most intriguing point relating to the Tax1 interactome is the very high number of cellular proteins to which this viral oncogene is able to interact. Today, about 100 Tax1-binding proteins are identified (Table 1) and this number is permanently growing (see for regular updates). Is it possible that a single protein modulates such a wide variety of functions? Are these interactions all relevant for the viral life cycle or pathogenesis? As schematized on Figure 5, the vast majority of these interactions contributes to viral or cellular gene expression and promotes infected cell proliferation or survival, required for maintaining viral load in vivo [231,305]. On the other hand, checkpoint abrogation allows proliferation of cells with DNA lesions and progressive accumulation of chromosomal abnormalities as frequently observed in ATL [220]. Even if one might entertain doubts about the biological relevance of some Tax1 partners, the Tax1 interactome as a whole likely contributes to the viral life cycle as well as to development of pathogenesis.

Bottom Line: Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation.To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins.In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.

View Article: PubMed Central - HTML - PubMed

Affiliation: University Academia Wallonie-Europe, Molecular and Cellular Biology at FUSAGx, Gembloux, Belgium. boxus.m@fsagx.ac.be

ABSTRACT
The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.

Show MeSH
Related in: MedlinePlus