Limits...
The HTLV-1 Tax interactome.

Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L - Retrovirology (2008)

Bottom Line: The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis.To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins.In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.

View Article: PubMed Central - HTML - PubMed

Affiliation: University Academia Wallonie-Europe, Molecular and Cellular Biology at FUSAGx, Gembloux, Belgium. boxus.m@fsagx.ac.be

ABSTRACT
The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.

Show MeSH

Related in: MedlinePlus

Overview of cell signaling proteins targeted by Tax1. Tax1 interacts with components of several signaling pathways (MAPK, JNK, NF-κB, AP-1 and TGF-β) and promotes cellular activation, proliferation, cytoskeleton rearrangement, cell migration and formation of the virological synapse.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2533353&req=5

Figure 2: Overview of cell signaling proteins targeted by Tax1. Tax1 interacts with components of several signaling pathways (MAPK, JNK, NF-κB, AP-1 and TGF-β) and promotes cellular activation, proliferation, cytoskeleton rearrangement, cell migration and formation of the virological synapse.

Mentions: As schematized on figure 2, Tax1 interactions with a series of components of several signaling pathways (MAPK, JNK, NF-κB, G proteins, AP1 and TGFβ) affect multiple cellular processes among which cellular activation, proliferation, cytoskeleton rearrangement, cell migration and formation of the virological synapse.


The HTLV-1 Tax interactome.

Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L - Retrovirology (2008)

Overview of cell signaling proteins targeted by Tax1. Tax1 interacts with components of several signaling pathways (MAPK, JNK, NF-κB, AP-1 and TGF-β) and promotes cellular activation, proliferation, cytoskeleton rearrangement, cell migration and formation of the virological synapse.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2533353&req=5

Figure 2: Overview of cell signaling proteins targeted by Tax1. Tax1 interacts with components of several signaling pathways (MAPK, JNK, NF-κB, AP-1 and TGF-β) and promotes cellular activation, proliferation, cytoskeleton rearrangement, cell migration and formation of the virological synapse.
Mentions: As schematized on figure 2, Tax1 interactions with a series of components of several signaling pathways (MAPK, JNK, NF-κB, G proteins, AP1 and TGFβ) affect multiple cellular processes among which cellular activation, proliferation, cytoskeleton rearrangement, cell migration and formation of the virological synapse.

Bottom Line: The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis.To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins.In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.

View Article: PubMed Central - HTML - PubMed

Affiliation: University Academia Wallonie-Europe, Molecular and Cellular Biology at FUSAGx, Gembloux, Belgium. boxus.m@fsagx.ac.be

ABSTRACT
The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.

Show MeSH
Related in: MedlinePlus