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Muscle invasive bladder cancer in Upper Egypt: the shift in risk factors and tumor characteristics.

Zarzour AH, Selim M, Abd-Elsayed AA, Hameed DA, Abdelaziz MA - BMC Cancer (2008)

Bottom Line: SCC represented 67.6% of cases with burning micturition being the presenting symptom in 73.8%.MIBC in Upper Egypt is usually of the SCC type (although its percentage is decreasing), occurs at a younger age and presents with burning micturition rather than hematuria.Unlike the common belief, positive family history, parents' consanguinity, exposure to pesticides and chronic cystitis seem to play now more important roles than bilharziasis and smoking in the development of this disease in this area.

View Article: PubMed Central - HTML - PubMed

Affiliation: Public health department, Faculty of Medicine, Assiut University, Assiut, Egypt. zarzourah@yahoo.com

ABSTRACT

Background: In Egypt, where bilharziasis is endemic, bladder cancer is the commonest cancer in males and the 2nd in females; squamous cell carcinoma (SCC) is the commonest type found, with a peculiar mode of presentation. The aim of this study is to identify and rank the risk factors of muscle invasive bladder cancer (MIBC) in Upper Egypt and describe its specific criteria of presentation and histopathology.

Methods: This is an analytical, hospital based, case controlled study conducted in south Egypt cancer institute through comparing MIBC cases (n = 130) with age, sex and residence matched controls (n = 260) for the presence of risk factors of MIBC. Data was collected by personal interview using a well designed questionnaire. Patients' records were reviewed for histopathology and Radiologic findings.

Results: The risk factors of MIBC were positive family history [Adjusted odds ratio (AOR) = 7.7], exposure to pesticides [AOR = 6.2], bladder stones [AOR = 5], consanguinity [AOR = 3.9], recurrent cystitis [AOR = 3.1], bilharziasis [odds ratio (OR) = 5.8] and smoking [OR = 5.3]. SCC represented 67.6% of cases with burning micturition being the presenting symptom in 73.8%.

Conclusion: MIBC in Upper Egypt is usually of the SCC type (although its percentage is decreasing), occurs at a younger age and presents with burning micturition rather than hematuria. Unlike the common belief, positive family history, parents' consanguinity, exposure to pesticides and chronic cystitis seem to play now more important roles than bilharziasis and smoking in the development of this disease in this area.

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Related in: MedlinePlus

Map of Egypt.
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Figure 1: Map of Egypt.

Mentions: The study was carried out in Upper Egypt which is a narrow strip of land that extends from the cataract boundaries of modern-day Aswan to the area between El-Aiyat and Zawyet Dahshur, south of modern-day Cairo, Figure 1.


Muscle invasive bladder cancer in Upper Egypt: the shift in risk factors and tumor characteristics.

Zarzour AH, Selim M, Abd-Elsayed AA, Hameed DA, Abdelaziz MA - BMC Cancer (2008)

Map of Egypt.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2533340&req=5

Figure 1: Map of Egypt.
Mentions: The study was carried out in Upper Egypt which is a narrow strip of land that extends from the cataract boundaries of modern-day Aswan to the area between El-Aiyat and Zawyet Dahshur, south of modern-day Cairo, Figure 1.

Bottom Line: SCC represented 67.6% of cases with burning micturition being the presenting symptom in 73.8%.MIBC in Upper Egypt is usually of the SCC type (although its percentage is decreasing), occurs at a younger age and presents with burning micturition rather than hematuria.Unlike the common belief, positive family history, parents' consanguinity, exposure to pesticides and chronic cystitis seem to play now more important roles than bilharziasis and smoking in the development of this disease in this area.

View Article: PubMed Central - HTML - PubMed

Affiliation: Public health department, Faculty of Medicine, Assiut University, Assiut, Egypt. zarzourah@yahoo.com

ABSTRACT

Background: In Egypt, where bilharziasis is endemic, bladder cancer is the commonest cancer in males and the 2nd in females; squamous cell carcinoma (SCC) is the commonest type found, with a peculiar mode of presentation. The aim of this study is to identify and rank the risk factors of muscle invasive bladder cancer (MIBC) in Upper Egypt and describe its specific criteria of presentation and histopathology.

Methods: This is an analytical, hospital based, case controlled study conducted in south Egypt cancer institute through comparing MIBC cases (n = 130) with age, sex and residence matched controls (n = 260) for the presence of risk factors of MIBC. Data was collected by personal interview using a well designed questionnaire. Patients' records were reviewed for histopathology and Radiologic findings.

Results: The risk factors of MIBC were positive family history [Adjusted odds ratio (AOR) = 7.7], exposure to pesticides [AOR = 6.2], bladder stones [AOR = 5], consanguinity [AOR = 3.9], recurrent cystitis [AOR = 3.1], bilharziasis [odds ratio (OR) = 5.8] and smoking [OR = 5.3]. SCC represented 67.6% of cases with burning micturition being the presenting symptom in 73.8%.

Conclusion: MIBC in Upper Egypt is usually of the SCC type (although its percentage is decreasing), occurs at a younger age and presents with burning micturition rather than hematuria. Unlike the common belief, positive family history, parents' consanguinity, exposure to pesticides and chronic cystitis seem to play now more important roles than bilharziasis and smoking in the development of this disease in this area.

Show MeSH
Related in: MedlinePlus