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Colonic involvement in a patient with chronic lymphocytic leukaemia.

Arkkila PE, Nuutinen H, Ebeling F, Elonen E, Kärkkäinen P, Karjalainen-Lindsberg ML - Gastroenterol Res Pract (2008)

Bottom Line: Various gastrointestinal infiltrations have been described in patients with chronic lymphocytic leukaemia (CLL).Here, we report a 69-year-old man with CLL and anaemia in whom the macroscopic finding of colonoscopy was normal, but the histological specimens revealed lymphocytic leukemia in ileum and in colon.If a CLL patient has any symptoms suggesting a possible GI manifestation of the haematologic disease or anaemia not explained by bone marrow infiltration or hemolysis, the diagnostic evaluation should include endoscopies with adequate biopsies.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Helsinki University Central Hospital, 00290 Helsinki, Finland. perttu.arkkila@fimnet.fi

ABSTRACT
Various gastrointestinal infiltrations have been described in patients with chronic lymphocytic leukaemia (CLL). Here, we report a 69-year-old man with CLL and anaemia in whom the macroscopic finding of colonoscopy was normal, but the histological specimens revealed lymphocytic leukemia in ileum and in colon. If a CLL patient has any symptoms suggesting a possible GI manifestation of the haematologic disease or anaemia not explained by bone marrow infiltration or hemolysis, the diagnostic evaluation should include endoscopies with adequate biopsies.

No MeSH data available.


Related in: MedlinePlus

Biopsy specimens revealed multiple diffuse CD20 positive (a) B-cell infiltratesinvolving mucosa and submucosa of colon without formation lymphoepitheliallesions. B-lymphocytes expressed also CD5 with low intensity (b) and CD23 (c),characteristic of small lymphocytic lymphoma (CLL).
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fig1: Biopsy specimens revealed multiple diffuse CD20 positive (a) B-cell infiltratesinvolving mucosa and submucosa of colon without formation lymphoepitheliallesions. B-lymphocytes expressed also CD5 with low intensity (b) and CD23 (c),characteristic of small lymphocytic lymphoma (CLL).

Mentions: Microscopically dense mucosal and submucosal lymphocyticinfiltrates were detected in ileum as well as 4/7 biopsies of colon (Figures 1(a), 1(b), and 1(c)), with predominance of small CD20 positive lymphocytes. Nolymphoepithelial lesions were observed. The cells stained positively also forCLL-associated antigens CD5 (low intensity), CD23, and CD43, but were negativefor mantle cell-associated antigen cyclin D1. Consecutively, ZAP-70 waspositive, and no immunohistochemical staining for CD38 or p53 was detected.


Colonic involvement in a patient with chronic lymphocytic leukaemia.

Arkkila PE, Nuutinen H, Ebeling F, Elonen E, Kärkkäinen P, Karjalainen-Lindsberg ML - Gastroenterol Res Pract (2008)

Biopsy specimens revealed multiple diffuse CD20 positive (a) B-cell infiltratesinvolving mucosa and submucosa of colon without formation lymphoepitheliallesions. B-lymphocytes expressed also CD5 with low intensity (b) and CD23 (c),characteristic of small lymphocytic lymphoma (CLL).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2533105&req=5

fig1: Biopsy specimens revealed multiple diffuse CD20 positive (a) B-cell infiltratesinvolving mucosa and submucosa of colon without formation lymphoepitheliallesions. B-lymphocytes expressed also CD5 with low intensity (b) and CD23 (c),characteristic of small lymphocytic lymphoma (CLL).
Mentions: Microscopically dense mucosal and submucosal lymphocyticinfiltrates were detected in ileum as well as 4/7 biopsies of colon (Figures 1(a), 1(b), and 1(c)), with predominance of small CD20 positive lymphocytes. Nolymphoepithelial lesions were observed. The cells stained positively also forCLL-associated antigens CD5 (low intensity), CD23, and CD43, but were negativefor mantle cell-associated antigen cyclin D1. Consecutively, ZAP-70 waspositive, and no immunohistochemical staining for CD38 or p53 was detected.

Bottom Line: Various gastrointestinal infiltrations have been described in patients with chronic lymphocytic leukaemia (CLL).Here, we report a 69-year-old man with CLL and anaemia in whom the macroscopic finding of colonoscopy was normal, but the histological specimens revealed lymphocytic leukemia in ileum and in colon.If a CLL patient has any symptoms suggesting a possible GI manifestation of the haematologic disease or anaemia not explained by bone marrow infiltration or hemolysis, the diagnostic evaluation should include endoscopies with adequate biopsies.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Helsinki University Central Hospital, 00290 Helsinki, Finland. perttu.arkkila@fimnet.fi

ABSTRACT
Various gastrointestinal infiltrations have been described in patients with chronic lymphocytic leukaemia (CLL). Here, we report a 69-year-old man with CLL and anaemia in whom the macroscopic finding of colonoscopy was normal, but the histological specimens revealed lymphocytic leukemia in ileum and in colon. If a CLL patient has any symptoms suggesting a possible GI manifestation of the haematologic disease or anaemia not explained by bone marrow infiltration or hemolysis, the diagnostic evaluation should include endoscopies with adequate biopsies.

No MeSH data available.


Related in: MedlinePlus