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Red Cabbage (Brassica oleracea) Ameliorates Diabetic Nephropathy in Rats.

Kataya HA, Hamza AA - Evid Based Complement Alternat Med (2008)

Bottom Line: This was accompanied by a significant increase in reduced glutathione and superoxide dismutase activity and a decrease in catalase activity and in the total antioxidant capacity of the kidneys.In addition, B. oleracea extract attenuated the adverse effect of diabetes on malondialdehyde, glutathione and superoxide dismutase activity as well as catalase activity and total antioxidant capacity of diabetic kidneys.In conclusion, the antioxidant and antihyperglycemic properties of B. oleracea extract may offer a potential therapeutic source for the treatment of diabetes.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Faculty of Science, UAE University, Al-Ain, PO Box: 17555, UAE.

ABSTRACT
The protective action against oxidative stress of red cabbage (Brassica oleracea) extract was investigated. Diabetes was induced in male Wistar rats using streptozotocin (60 mg/kg body weight). Throughout the experimental period (60 days), diabetic rats exhibited many symptoms including loss of body weight, hyperglycemia, polyuria, polydipsia, renal enlargement and renal dysfunction. Significant increase in malondialdehyde, a lipid peroxidation marker, was observed in diabetic kidney. This was accompanied by a significant increase in reduced glutathione and superoxide dismutase activity and a decrease in catalase activity and in the total antioxidant capacity of the kidneys. Daily oral ingestion (1 g/kg body weight) of B. oleracea extract for 60 days reversed the adverse effect of diabetes in rats. B. oleracea extract lowered blood glucose levels and restored renal function and body weight loss. In addition, B. oleracea extract attenuated the adverse effect of diabetes on malondialdehyde, glutathione and superoxide dismutase activity as well as catalase activity and total antioxidant capacity of diabetic kidneys. In conclusion, the antioxidant and antihyperglycemic properties of B. oleracea extract may offer a potential therapeutic source for the treatment of diabetes.

No MeSH data available.


Related in: MedlinePlus

Serum urea concentrations. ***P < 0.001, as compared with control, ↑↑P < 0.01; ↑↑↑P < 0.001 as compared with diabetic.
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Figure 4: Serum urea concentrations. ***P < 0.001, as compared with control, ↑↑P < 0.01; ↑↑↑P < 0.001 as compared with diabetic.

Mentions: At the end of the experimental period (60 days), diabetic rats exhibited significant (P < 0.001) renal enlargement as compared with non-diabetic control rats (Fig. 3). In diabetic rats, elevation in serum urea (Fig. 4) and serum creatinine concentrations (Fig. 5) indicated impairment in kidney function. Kidney nephropathy was improved when RC extract was ingested. Fig. 3 shows that kidney weight in diabetic rats that ingested RC extract was not different from control rats (P > 0.05). In addition, serum urea (Fig. 4) as well as serum creatinine (Fig. 5) concentrations were ameliorated with ingestion of RC extract.Figure 3.


Red Cabbage (Brassica oleracea) Ameliorates Diabetic Nephropathy in Rats.

Kataya HA, Hamza AA - Evid Based Complement Alternat Med (2008)

Serum urea concentrations. ***P < 0.001, as compared with control, ↑↑P < 0.01; ↑↑↑P < 0.001 as compared with diabetic.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2529380&req=5

Figure 4: Serum urea concentrations. ***P < 0.001, as compared with control, ↑↑P < 0.01; ↑↑↑P < 0.001 as compared with diabetic.
Mentions: At the end of the experimental period (60 days), diabetic rats exhibited significant (P < 0.001) renal enlargement as compared with non-diabetic control rats (Fig. 3). In diabetic rats, elevation in serum urea (Fig. 4) and serum creatinine concentrations (Fig. 5) indicated impairment in kidney function. Kidney nephropathy was improved when RC extract was ingested. Fig. 3 shows that kidney weight in diabetic rats that ingested RC extract was not different from control rats (P > 0.05). In addition, serum urea (Fig. 4) as well as serum creatinine (Fig. 5) concentrations were ameliorated with ingestion of RC extract.Figure 3.

Bottom Line: This was accompanied by a significant increase in reduced glutathione and superoxide dismutase activity and a decrease in catalase activity and in the total antioxidant capacity of the kidneys.In addition, B. oleracea extract attenuated the adverse effect of diabetes on malondialdehyde, glutathione and superoxide dismutase activity as well as catalase activity and total antioxidant capacity of diabetic kidneys.In conclusion, the antioxidant and antihyperglycemic properties of B. oleracea extract may offer a potential therapeutic source for the treatment of diabetes.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Faculty of Science, UAE University, Al-Ain, PO Box: 17555, UAE.

ABSTRACT
The protective action against oxidative stress of red cabbage (Brassica oleracea) extract was investigated. Diabetes was induced in male Wistar rats using streptozotocin (60 mg/kg body weight). Throughout the experimental period (60 days), diabetic rats exhibited many symptoms including loss of body weight, hyperglycemia, polyuria, polydipsia, renal enlargement and renal dysfunction. Significant increase in malondialdehyde, a lipid peroxidation marker, was observed in diabetic kidney. This was accompanied by a significant increase in reduced glutathione and superoxide dismutase activity and a decrease in catalase activity and in the total antioxidant capacity of the kidneys. Daily oral ingestion (1 g/kg body weight) of B. oleracea extract for 60 days reversed the adverse effect of diabetes in rats. B. oleracea extract lowered blood glucose levels and restored renal function and body weight loss. In addition, B. oleracea extract attenuated the adverse effect of diabetes on malondialdehyde, glutathione and superoxide dismutase activity as well as catalase activity and total antioxidant capacity of diabetic kidneys. In conclusion, the antioxidant and antihyperglycemic properties of B. oleracea extract may offer a potential therapeutic source for the treatment of diabetes.

No MeSH data available.


Related in: MedlinePlus