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Red Cabbage (Brassica oleracea) Ameliorates Diabetic Nephropathy in Rats.

Kataya HA, Hamza AA - Evid Based Complement Alternat Med (2008)

Bottom Line: This was accompanied by a significant increase in reduced glutathione and superoxide dismutase activity and a decrease in catalase activity and in the total antioxidant capacity of the kidneys.In addition, B. oleracea extract attenuated the adverse effect of diabetes on malondialdehyde, glutathione and superoxide dismutase activity as well as catalase activity and total antioxidant capacity of diabetic kidneys.In conclusion, the antioxidant and antihyperglycemic properties of B. oleracea extract may offer a potential therapeutic source for the treatment of diabetes.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Faculty of Science, UAE University, Al-Ain, PO Box: 17555, UAE.

ABSTRACT
The protective action against oxidative stress of red cabbage (Brassica oleracea) extract was investigated. Diabetes was induced in male Wistar rats using streptozotocin (60 mg/kg body weight). Throughout the experimental period (60 days), diabetic rats exhibited many symptoms including loss of body weight, hyperglycemia, polyuria, polydipsia, renal enlargement and renal dysfunction. Significant increase in malondialdehyde, a lipid peroxidation marker, was observed in diabetic kidney. This was accompanied by a significant increase in reduced glutathione and superoxide dismutase activity and a decrease in catalase activity and in the total antioxidant capacity of the kidneys. Daily oral ingestion (1 g/kg body weight) of B. oleracea extract for 60 days reversed the adverse effect of diabetes in rats. B. oleracea extract lowered blood glucose levels and restored renal function and body weight loss. In addition, B. oleracea extract attenuated the adverse effect of diabetes on malondialdehyde, glutathione and superoxide dismutase activity as well as catalase activity and total antioxidant capacity of diabetic kidneys. In conclusion, the antioxidant and antihyperglycemic properties of B. oleracea extract may offer a potential therapeutic source for the treatment of diabetes.

No MeSH data available.


Related in: MedlinePlus

Kidney GSH concentrations. ***P < 0.001, as compared with control, ↑↑↑P < 0.001 as compared with diabetic.
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Figure 10: Kidney GSH concentrations. ***P < 0.001, as compared with control, ↑↑↑P < 0.001 as compared with diabetic.

Mentions: To understand the effect of RC extract on antioxidant eminence, we measured the activities of enzymic antioxidants SOD and CAT and non-enzymic antioxidant GSH. SOD activity showed an increase (P < 0.05) at the end of experimental period (Fig. 8). Meanwhile, a significant decline (P < 0.01) in CAT activity was observed in diabetic rats (Fig. 9). GSH activity increased (P < 0.001) in diabetic rats (Fig. 10). Both enzymic and non-enzymic antioxidants were ameliorated after ingesting RC extract.Figure 8.


Red Cabbage (Brassica oleracea) Ameliorates Diabetic Nephropathy in Rats.

Kataya HA, Hamza AA - Evid Based Complement Alternat Med (2008)

Kidney GSH concentrations. ***P < 0.001, as compared with control, ↑↑↑P < 0.001 as compared with diabetic.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2529380&req=5

Figure 10: Kidney GSH concentrations. ***P < 0.001, as compared with control, ↑↑↑P < 0.001 as compared with diabetic.
Mentions: To understand the effect of RC extract on antioxidant eminence, we measured the activities of enzymic antioxidants SOD and CAT and non-enzymic antioxidant GSH. SOD activity showed an increase (P < 0.05) at the end of experimental period (Fig. 8). Meanwhile, a significant decline (P < 0.01) in CAT activity was observed in diabetic rats (Fig. 9). GSH activity increased (P < 0.001) in diabetic rats (Fig. 10). Both enzymic and non-enzymic antioxidants were ameliorated after ingesting RC extract.Figure 8.

Bottom Line: This was accompanied by a significant increase in reduced glutathione and superoxide dismutase activity and a decrease in catalase activity and in the total antioxidant capacity of the kidneys.In addition, B. oleracea extract attenuated the adverse effect of diabetes on malondialdehyde, glutathione and superoxide dismutase activity as well as catalase activity and total antioxidant capacity of diabetic kidneys.In conclusion, the antioxidant and antihyperglycemic properties of B. oleracea extract may offer a potential therapeutic source for the treatment of diabetes.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Faculty of Science, UAE University, Al-Ain, PO Box: 17555, UAE.

ABSTRACT
The protective action against oxidative stress of red cabbage (Brassica oleracea) extract was investigated. Diabetes was induced in male Wistar rats using streptozotocin (60 mg/kg body weight). Throughout the experimental period (60 days), diabetic rats exhibited many symptoms including loss of body weight, hyperglycemia, polyuria, polydipsia, renal enlargement and renal dysfunction. Significant increase in malondialdehyde, a lipid peroxidation marker, was observed in diabetic kidney. This was accompanied by a significant increase in reduced glutathione and superoxide dismutase activity and a decrease in catalase activity and in the total antioxidant capacity of the kidneys. Daily oral ingestion (1 g/kg body weight) of B. oleracea extract for 60 days reversed the adverse effect of diabetes in rats. B. oleracea extract lowered blood glucose levels and restored renal function and body weight loss. In addition, B. oleracea extract attenuated the adverse effect of diabetes on malondialdehyde, glutathione and superoxide dismutase activity as well as catalase activity and total antioxidant capacity of diabetic kidneys. In conclusion, the antioxidant and antihyperglycemic properties of B. oleracea extract may offer a potential therapeutic source for the treatment of diabetes.

No MeSH data available.


Related in: MedlinePlus