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Red Cabbage (Brassica oleracea) Ameliorates Diabetic Nephropathy in Rats.

Kataya HA, Hamza AA - Evid Based Complement Alternat Med (2008)

Bottom Line: This was accompanied by a significant increase in reduced glutathione and superoxide dismutase activity and a decrease in catalase activity and in the total antioxidant capacity of the kidneys.In addition, B. oleracea extract attenuated the adverse effect of diabetes on malondialdehyde, glutathione and superoxide dismutase activity as well as catalase activity and total antioxidant capacity of diabetic kidneys.In conclusion, the antioxidant and antihyperglycemic properties of B. oleracea extract may offer a potential therapeutic source for the treatment of diabetes.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Faculty of Science, UAE University, Al-Ain, PO Box: 17555, UAE.

ABSTRACT
The protective action against oxidative stress of red cabbage (Brassica oleracea) extract was investigated. Diabetes was induced in male Wistar rats using streptozotocin (60 mg/kg body weight). Throughout the experimental period (60 days), diabetic rats exhibited many symptoms including loss of body weight, hyperglycemia, polyuria, polydipsia, renal enlargement and renal dysfunction. Significant increase in malondialdehyde, a lipid peroxidation marker, was observed in diabetic kidney. This was accompanied by a significant increase in reduced glutathione and superoxide dismutase activity and a decrease in catalase activity and in the total antioxidant capacity of the kidneys. Daily oral ingestion (1 g/kg body weight) of B. oleracea extract for 60 days reversed the adverse effect of diabetes in rats. B. oleracea extract lowered blood glucose levels and restored renal function and body weight loss. In addition, B. oleracea extract attenuated the adverse effect of diabetes on malondialdehyde, glutathione and superoxide dismutase activity as well as catalase activity and total antioxidant capacity of diabetic kidneys. In conclusion, the antioxidant and antihyperglycemic properties of B. oleracea extract may offer a potential therapeutic source for the treatment of diabetes.

No MeSH data available.


Related in: MedlinePlus

Body weight changes in rats that did not ingest (Control) or ingested RC extract (RC), and STZ-induced diabetes in rats that did not ingest (Diabetic) or ingested RC extract (Diabetic+RC), ***P < 0.001 as compared with control, ↑↑P < 0.01 as compared with diabetic.
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Figure 1: Body weight changes in rats that did not ingest (Control) or ingested RC extract (RC), and STZ-induced diabetes in rats that did not ingest (Diabetic) or ingested RC extract (Diabetic+RC), ***P < 0.001 as compared with control, ↑↑P < 0.01 as compared with diabetic.

Mentions: Intraperitoneal administration of STZ (60 mg/kg body weight) induced all characteristic symptoms of diabetes such as increased food and water intake (judged by the amount of food and water consumed per day), polyuria (data are not shown), failure to gain weight (Fig. 1). These symptoms were evident throughout the entire experimental period of 60 days. After 72 h of STZ injections, fasting blood glucose concentrations were increased as compared with non-diabetic control rats (Fig. 2). Blood glucose levels above 200 mg/dl were considered diabetic. Diabetic rats that daily ingested polar extract of RC (1 g/kg body weight) showed improvement in diabetic polyuria that almost disappeared by the end of the experimental period. Food and water consumption also declined when diabetic rats ingested RC extract. RC extract also abridged the weight gain loss in diabetic rats (Fig. 1) as well as blood glucose levels (Fig. 2) at the end of the experimental period. Rats that ingested RC extract showed no significant changes as compared with control rats in any of the parameters considered.Figure 1.


Red Cabbage (Brassica oleracea) Ameliorates Diabetic Nephropathy in Rats.

Kataya HA, Hamza AA - Evid Based Complement Alternat Med (2008)

Body weight changes in rats that did not ingest (Control) or ingested RC extract (RC), and STZ-induced diabetes in rats that did not ingest (Diabetic) or ingested RC extract (Diabetic+RC), ***P < 0.001 as compared with control, ↑↑P < 0.01 as compared with diabetic.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2529380&req=5

Figure 1: Body weight changes in rats that did not ingest (Control) or ingested RC extract (RC), and STZ-induced diabetes in rats that did not ingest (Diabetic) or ingested RC extract (Diabetic+RC), ***P < 0.001 as compared with control, ↑↑P < 0.01 as compared with diabetic.
Mentions: Intraperitoneal administration of STZ (60 mg/kg body weight) induced all characteristic symptoms of diabetes such as increased food and water intake (judged by the amount of food and water consumed per day), polyuria (data are not shown), failure to gain weight (Fig. 1). These symptoms were evident throughout the entire experimental period of 60 days. After 72 h of STZ injections, fasting blood glucose concentrations were increased as compared with non-diabetic control rats (Fig. 2). Blood glucose levels above 200 mg/dl were considered diabetic. Diabetic rats that daily ingested polar extract of RC (1 g/kg body weight) showed improvement in diabetic polyuria that almost disappeared by the end of the experimental period. Food and water consumption also declined when diabetic rats ingested RC extract. RC extract also abridged the weight gain loss in diabetic rats (Fig. 1) as well as blood glucose levels (Fig. 2) at the end of the experimental period. Rats that ingested RC extract showed no significant changes as compared with control rats in any of the parameters considered.Figure 1.

Bottom Line: This was accompanied by a significant increase in reduced glutathione and superoxide dismutase activity and a decrease in catalase activity and in the total antioxidant capacity of the kidneys.In addition, B. oleracea extract attenuated the adverse effect of diabetes on malondialdehyde, glutathione and superoxide dismutase activity as well as catalase activity and total antioxidant capacity of diabetic kidneys.In conclusion, the antioxidant and antihyperglycemic properties of B. oleracea extract may offer a potential therapeutic source for the treatment of diabetes.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, Faculty of Science, UAE University, Al-Ain, PO Box: 17555, UAE.

ABSTRACT
The protective action against oxidative stress of red cabbage (Brassica oleracea) extract was investigated. Diabetes was induced in male Wistar rats using streptozotocin (60 mg/kg body weight). Throughout the experimental period (60 days), diabetic rats exhibited many symptoms including loss of body weight, hyperglycemia, polyuria, polydipsia, renal enlargement and renal dysfunction. Significant increase in malondialdehyde, a lipid peroxidation marker, was observed in diabetic kidney. This was accompanied by a significant increase in reduced glutathione and superoxide dismutase activity and a decrease in catalase activity and in the total antioxidant capacity of the kidneys. Daily oral ingestion (1 g/kg body weight) of B. oleracea extract for 60 days reversed the adverse effect of diabetes in rats. B. oleracea extract lowered blood glucose levels and restored renal function and body weight loss. In addition, B. oleracea extract attenuated the adverse effect of diabetes on malondialdehyde, glutathione and superoxide dismutase activity as well as catalase activity and total antioxidant capacity of diabetic kidneys. In conclusion, the antioxidant and antihyperglycemic properties of B. oleracea extract may offer a potential therapeutic source for the treatment of diabetes.

No MeSH data available.


Related in: MedlinePlus