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Brain stimulation modulates driving behavior.

Beeli G, Koeneke S, Gasser K, Jancke L - Behav Brain Funct (2008)

Bottom Line: Controlled and safe driving depends on the integrity of the dorsolateral prefrontal cortex (DLPFC), a brain region, which has been shown to mature in late adolescence.We show that external modulation of both, the left and the right, DLPFC directly influences driving behavior.Excitation of the DLPFC (by applying anodal tDCS) leads to a more careful driving style in virtual scenarios without the participants noticing changes in their behavior.

View Article: PubMed Central - HTML - PubMed

Affiliation: University of Zurich, Institute of Psychology, Division Neuropsychology, Switzerland. s.koeneke@psychologie.uzh.ch.

ABSTRACT

Background: Driving a car is a complex task requiring coordinated functioning of distributed brain regions. Controlled and safe driving depends on the integrity of the dorsolateral prefrontal cortex (DLPFC), a brain region, which has been shown to mature in late adolescence.

Methods: In this study, driving performance of twenty-four male participants was tested in a high-end driving simulator before and after the application of transcranial direct current stimulation (tDCS) for 15 minutes over the left or right DLPFC.

Results: We show that external modulation of both, the left and the right, DLPFC directly influences driving behavior. Excitation of the DLPFC (by applying anodal tDCS) leads to a more careful driving style in virtual scenarios without the participants noticing changes in their behavior.

Conclusion: This study is one of the first to prove that external stimulation of a specific brain area can influence a multi-part behavior in a very complex and everyday-life situation, therefore breaking new ground for therapy at a neural level.

No MeSH data available.


Left- vs. right-hemispheric DLPFC stimulation. Depicted are performance changes from pre- to post-stimulation measurements in percent ((POST*100)/PRE) and standard errors (SE) separately for two experimental groups (left DLPFC and right DLPFC stimulation).
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Figure 2: Left- vs. right-hemispheric DLPFC stimulation. Depicted are performance changes from pre- to post-stimulation measurements in percent ((POST*100)/PRE) and standard errors (SE) separately for two experimental groups (left DLPFC and right DLPFC stimulation).

Mentions: To compare the two groups, post-stimulation performance was related to the individual pre-stimulation performance for each participant (a posttraining value of 100% means no change from pre- to posttraining). The corresponding values are depicted in figure 2. Since, in case of cathodal stimulation, the resulting values did not differ significantly from the reference value (100%), we refrain from comparing between-group differences. With respect to anodal tDCS, two-sample t-tests comparing the performance changes between the two groups resulted in p-values > 0.4 for all behavioral variables.


Brain stimulation modulates driving behavior.

Beeli G, Koeneke S, Gasser K, Jancke L - Behav Brain Funct (2008)

Left- vs. right-hemispheric DLPFC stimulation. Depicted are performance changes from pre- to post-stimulation measurements in percent ((POST*100)/PRE) and standard errors (SE) separately for two experimental groups (left DLPFC and right DLPFC stimulation).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2527008&req=5

Figure 2: Left- vs. right-hemispheric DLPFC stimulation. Depicted are performance changes from pre- to post-stimulation measurements in percent ((POST*100)/PRE) and standard errors (SE) separately for two experimental groups (left DLPFC and right DLPFC stimulation).
Mentions: To compare the two groups, post-stimulation performance was related to the individual pre-stimulation performance for each participant (a posttraining value of 100% means no change from pre- to posttraining). The corresponding values are depicted in figure 2. Since, in case of cathodal stimulation, the resulting values did not differ significantly from the reference value (100%), we refrain from comparing between-group differences. With respect to anodal tDCS, two-sample t-tests comparing the performance changes between the two groups resulted in p-values > 0.4 for all behavioral variables.

Bottom Line: Controlled and safe driving depends on the integrity of the dorsolateral prefrontal cortex (DLPFC), a brain region, which has been shown to mature in late adolescence.We show that external modulation of both, the left and the right, DLPFC directly influences driving behavior.Excitation of the DLPFC (by applying anodal tDCS) leads to a more careful driving style in virtual scenarios without the participants noticing changes in their behavior.

View Article: PubMed Central - HTML - PubMed

Affiliation: University of Zurich, Institute of Psychology, Division Neuropsychology, Switzerland. s.koeneke@psychologie.uzh.ch.

ABSTRACT

Background: Driving a car is a complex task requiring coordinated functioning of distributed brain regions. Controlled and safe driving depends on the integrity of the dorsolateral prefrontal cortex (DLPFC), a brain region, which has been shown to mature in late adolescence.

Methods: In this study, driving performance of twenty-four male participants was tested in a high-end driving simulator before and after the application of transcranial direct current stimulation (tDCS) for 15 minutes over the left or right DLPFC.

Results: We show that external modulation of both, the left and the right, DLPFC directly influences driving behavior. Excitation of the DLPFC (by applying anodal tDCS) leads to a more careful driving style in virtual scenarios without the participants noticing changes in their behavior.

Conclusion: This study is one of the first to prove that external stimulation of a specific brain area can influence a multi-part behavior in a very complex and everyday-life situation, therefore breaking new ground for therapy at a neural level.

No MeSH data available.