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Histological variants of cutaneous Kaposi sarcoma.

Grayson W, Pantanowitz L - Diagn Pathol (2008)

Bottom Line: This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions.Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS.Involuting lesions as a result of treatment related regression are also presented.

View Article: PubMed Central - HTML - PubMed

Affiliation: Histopathology Department, Ampath National Laboratory Support Services, Johannesburg, South Africa. wayne.grayson@live.com

ABSTRACT
This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions. Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS. Involuting lesions as a result of treatment related regression are also presented.

No MeSH data available.


Related in: MedlinePlus

Plaque stage Kaposi sarcoma. Large numbers of intracellular and extracellular eosinophilic hyaline globules are visible in this field (H&E stain). The arrows indicate so-called "autolumination", with paranuclear vacuoles containing erythrocytes.
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Figure 2: Plaque stage Kaposi sarcoma. Large numbers of intracellular and extracellular eosinophilic hyaline globules are visible in this field (H&E stain). The arrows indicate so-called "autolumination", with paranuclear vacuoles containing erythrocytes.

Mentions: In plaque stage lesions of KS, the histologic picture is characterized by a more diffuse dermal vascular infiltrate, accompanied by greater cellularity and occasional extension of this process into the underlying subcutaneous adipose tissue. The lesional cells tend to be more spindled and arranged in short, sometimes haphazard fascicles [1-4]. Fascicles cut in cross section demonstrate a sieve-like appearance. Mitotic figures are sparse and there is no significant nuclear or cytological pleomorphism. Intra- and extracellular hyaline globules, probably representing effete erythrocytes, are often seen. Careful scrutiny will frequently reveal "autolumination", whereby an erythrocyte is contained within a clear paranuclear vacuole in the cytoplasm of a spindled endothelial cell observed in cross section (Figure 2). Numerous dissecting vascular channels containing erythrocytes occupy the intervening dermis, and once again there is evidence of a background plasma cell-rich contingent of chronic inflammatory cells with admixed siderophages and free-lying hemosiderin pigment. The promontory sign, as described above, may also be encountered [1-4]. The histologic differential diagnosis includes tufted angioma, targetoid hemosiderotic hemangioma, microvenular hemangioma and acroangiodermatitis ("pseudo-Kaposi's sarcoma") [1,2,4].


Histological variants of cutaneous Kaposi sarcoma.

Grayson W, Pantanowitz L - Diagn Pathol (2008)

Plaque stage Kaposi sarcoma. Large numbers of intracellular and extracellular eosinophilic hyaline globules are visible in this field (H&E stain). The arrows indicate so-called "autolumination", with paranuclear vacuoles containing erythrocytes.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2526984&req=5

Figure 2: Plaque stage Kaposi sarcoma. Large numbers of intracellular and extracellular eosinophilic hyaline globules are visible in this field (H&E stain). The arrows indicate so-called "autolumination", with paranuclear vacuoles containing erythrocytes.
Mentions: In plaque stage lesions of KS, the histologic picture is characterized by a more diffuse dermal vascular infiltrate, accompanied by greater cellularity and occasional extension of this process into the underlying subcutaneous adipose tissue. The lesional cells tend to be more spindled and arranged in short, sometimes haphazard fascicles [1-4]. Fascicles cut in cross section demonstrate a sieve-like appearance. Mitotic figures are sparse and there is no significant nuclear or cytological pleomorphism. Intra- and extracellular hyaline globules, probably representing effete erythrocytes, are often seen. Careful scrutiny will frequently reveal "autolumination", whereby an erythrocyte is contained within a clear paranuclear vacuole in the cytoplasm of a spindled endothelial cell observed in cross section (Figure 2). Numerous dissecting vascular channels containing erythrocytes occupy the intervening dermis, and once again there is evidence of a background plasma cell-rich contingent of chronic inflammatory cells with admixed siderophages and free-lying hemosiderin pigment. The promontory sign, as described above, may also be encountered [1-4]. The histologic differential diagnosis includes tufted angioma, targetoid hemosiderotic hemangioma, microvenular hemangioma and acroangiodermatitis ("pseudo-Kaposi's sarcoma") [1,2,4].

Bottom Line: This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions.Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS.Involuting lesions as a result of treatment related regression are also presented.

View Article: PubMed Central - HTML - PubMed

Affiliation: Histopathology Department, Ampath National Laboratory Support Services, Johannesburg, South Africa. wayne.grayson@live.com

ABSTRACT
This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions. Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS. Involuting lesions as a result of treatment related regression are also presented.

No MeSH data available.


Related in: MedlinePlus