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Histological variants of cutaneous Kaposi sarcoma.

Grayson W, Pantanowitz L - Diagn Pathol (2008)

Bottom Line: This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions.Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS.Involuting lesions as a result of treatment related regression are also presented.

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Affiliation: Histopathology Department, Ampath National Laboratory Support Services, Johannesburg, South Africa. wayne.grayson@live.com

ABSTRACT
This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions. Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS. Involuting lesions as a result of treatment related regression are also presented.

No MeSH data available.


Related in: MedlinePlus

Ecchymotic Kaposi sarcoma. The spindled cell proliferation in this example is somewhat obscured by the extensive purpura.
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Figure 18: Ecchymotic Kaposi sarcoma. The spindled cell proliferation in this example is somewhat obscured by the extensive purpura.

Mentions: In the variant referred to as ecchymotic KS, the intradermal KS proliferation is accompanied by extensive red blood cell extravasation (Figure 18) [49]. The marked purpura often obscures the underlying histologic features of KS. The differential diagnosis includes intralesional hemorrhage brought about the biopsy procedure itself. Clinically, this variant of AIDS-associated KS manifests with ecchymotic or pityriasis-like patches [49]. Ecchymotic plaque lesions may clinically also resemble a bruise or port-wine stain. A rare case of clinical "hemorrhagic" KS has been reported [50]. However, it is unclear if the appearance in this case was attributed to extensive erythrocyte extravassation.


Histological variants of cutaneous Kaposi sarcoma.

Grayson W, Pantanowitz L - Diagn Pathol (2008)

Ecchymotic Kaposi sarcoma. The spindled cell proliferation in this example is somewhat obscured by the extensive purpura.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2526984&req=5

Figure 18: Ecchymotic Kaposi sarcoma. The spindled cell proliferation in this example is somewhat obscured by the extensive purpura.
Mentions: In the variant referred to as ecchymotic KS, the intradermal KS proliferation is accompanied by extensive red blood cell extravasation (Figure 18) [49]. The marked purpura often obscures the underlying histologic features of KS. The differential diagnosis includes intralesional hemorrhage brought about the biopsy procedure itself. Clinically, this variant of AIDS-associated KS manifests with ecchymotic or pityriasis-like patches [49]. Ecchymotic plaque lesions may clinically also resemble a bruise or port-wine stain. A rare case of clinical "hemorrhagic" KS has been reported [50]. However, it is unclear if the appearance in this case was attributed to extensive erythrocyte extravassation.

Bottom Line: This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions.Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS.Involuting lesions as a result of treatment related regression are also presented.

View Article: PubMed Central - HTML - PubMed

Affiliation: Histopathology Department, Ampath National Laboratory Support Services, Johannesburg, South Africa. wayne.grayson@live.com

ABSTRACT
This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions. Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS. Involuting lesions as a result of treatment related regression are also presented.

No MeSH data available.


Related in: MedlinePlus