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Histological variants of cutaneous Kaposi sarcoma.

Grayson W, Pantanowitz L - Diagn Pathol (2008)

Bottom Line: This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions.Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS.Involuting lesions as a result of treatment related regression are also presented.

View Article: PubMed Central - HTML - PubMed

Affiliation: Histopathology Department, Ampath National Laboratory Support Services, Johannesburg, South Africa. wayne.grayson@live.com

ABSTRACT
This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions. Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS. Involuting lesions as a result of treatment related regression are also presented.

No MeSH data available.


Related in: MedlinePlus

Keloidal Kaposi sarcoma.A. Spindled cells from the edge of the Kaposi sarcoma plaque lesion (upper left) are flanked by an expanse of keloid-like collagen (lower right) (H&E stain). B. Masson's trichrome stain highlighting the keloidal collagen bundles. Note the many extravasated erythrocytes in the background.
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Figure 15: Keloidal Kaposi sarcoma.A. Spindled cells from the edge of the Kaposi sarcoma plaque lesion (upper left) are flanked by an expanse of keloid-like collagen (lower right) (H&E stain). B. Masson's trichrome stain highlighting the keloidal collagen bundles. Note the many extravasated erythrocytes in the background.

Mentions: The description of this exceedingly uncommon KS variant is limited to a 1994 report of three cases [46]. Lesions are firm and rubbery, and may be linear [6]. Histologically, there is notable dermal expansion by dense, hyalinized collagen with a distinct resemblance to a keloid (Figure 15). In such lesions the spindled KS proliferation may be obscured by these keloidal alterations. The histologic differential diagnosis includes a dermal scar at the site of a previous skin biopsy of a KS lesion. It is postulated that cytokines play a key role in the evolution of the keloidal stromal changes in this unusual variant [46].


Histological variants of cutaneous Kaposi sarcoma.

Grayson W, Pantanowitz L - Diagn Pathol (2008)

Keloidal Kaposi sarcoma.A. Spindled cells from the edge of the Kaposi sarcoma plaque lesion (upper left) are flanked by an expanse of keloid-like collagen (lower right) (H&E stain). B. Masson's trichrome stain highlighting the keloidal collagen bundles. Note the many extravasated erythrocytes in the background.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2526984&req=5

Figure 15: Keloidal Kaposi sarcoma.A. Spindled cells from the edge of the Kaposi sarcoma plaque lesion (upper left) are flanked by an expanse of keloid-like collagen (lower right) (H&E stain). B. Masson's trichrome stain highlighting the keloidal collagen bundles. Note the many extravasated erythrocytes in the background.
Mentions: The description of this exceedingly uncommon KS variant is limited to a 1994 report of three cases [46]. Lesions are firm and rubbery, and may be linear [6]. Histologically, there is notable dermal expansion by dense, hyalinized collagen with a distinct resemblance to a keloid (Figure 15). In such lesions the spindled KS proliferation may be obscured by these keloidal alterations. The histologic differential diagnosis includes a dermal scar at the site of a previous skin biopsy of a KS lesion. It is postulated that cytokines play a key role in the evolution of the keloidal stromal changes in this unusual variant [46].

Bottom Line: This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions.Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS.Involuting lesions as a result of treatment related regression are also presented.

View Article: PubMed Central - HTML - PubMed

Affiliation: Histopathology Department, Ampath National Laboratory Support Services, Johannesburg, South Africa. wayne.grayson@live.com

ABSTRACT
This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions. Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS. Involuting lesions as a result of treatment related regression are also presented.

No MeSH data available.


Related in: MedlinePlus