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Histological variants of cutaneous Kaposi sarcoma.

Grayson W, Pantanowitz L - Diagn Pathol (2008)

Bottom Line: This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions.Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS.Involuting lesions as a result of treatment related regression are also presented.

View Article: PubMed Central - HTML - PubMed

Affiliation: Histopathology Department, Ampath National Laboratory Support Services, Johannesburg, South Africa. wayne.grayson@live.com

ABSTRACT
This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions. Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS. Involuting lesions as a result of treatment related regression are also presented.

No MeSH data available.


Related in: MedlinePlus

A CD31 immunostain highlights the many dilated vascular spaces seen in telangiectatic Kaposi sarcoma.
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Figure 12: A CD31 immunostain highlights the many dilated vascular spaces seen in telangiectatic Kaposi sarcoma.

Mentions: There is a single case report of telangiectatic KS, which occurred in a man with thymoma and myasthenia gravis receiving long-term immunosuppressive therapy [43]. The term "telangiectatic" referred to the significant telangiectasia associated with the multiple cutaneous nodules, and not the histopathologic features thereof. The histopathology in this case report showed usual features of nodular KS, with no conspicuous background vascular ectasia [43]. The authors have encountered rare histological examples of telangiectatic KS in which nodular KS lesions contained large, intensely congested, ectatic vascular spaces (Figure 11). Since these large spaces are lined by endothelial cells (Figure 12) whose nuclei are immunoreactive for LNA-1, it must be assumed that they are an integral part of the KS and not merely native dermal vessels that have undergone telangiectasia as a consequence of compression by the dermal tumor.


Histological variants of cutaneous Kaposi sarcoma.

Grayson W, Pantanowitz L - Diagn Pathol (2008)

A CD31 immunostain highlights the many dilated vascular spaces seen in telangiectatic Kaposi sarcoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2526984&req=5

Figure 12: A CD31 immunostain highlights the many dilated vascular spaces seen in telangiectatic Kaposi sarcoma.
Mentions: There is a single case report of telangiectatic KS, which occurred in a man with thymoma and myasthenia gravis receiving long-term immunosuppressive therapy [43]. The term "telangiectatic" referred to the significant telangiectasia associated with the multiple cutaneous nodules, and not the histopathologic features thereof. The histopathology in this case report showed usual features of nodular KS, with no conspicuous background vascular ectasia [43]. The authors have encountered rare histological examples of telangiectatic KS in which nodular KS lesions contained large, intensely congested, ectatic vascular spaces (Figure 11). Since these large spaces are lined by endothelial cells (Figure 12) whose nuclei are immunoreactive for LNA-1, it must be assumed that they are an integral part of the KS and not merely native dermal vessels that have undergone telangiectasia as a consequence of compression by the dermal tumor.

Bottom Line: This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions.Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS.Involuting lesions as a result of treatment related regression are also presented.

View Article: PubMed Central - HTML - PubMed

Affiliation: Histopathology Department, Ampath National Laboratory Support Services, Johannesburg, South Africa. wayne.grayson@live.com

ABSTRACT
This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions. Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS. Involuting lesions as a result of treatment related regression are also presented.

No MeSH data available.


Related in: MedlinePlus